The drug forms a complex
with cyclophilin A and a third protein, calcineurin, which is needed to activate the T cells of the immune system.
Jeremy Luban and his colleagues at Columbia University in New York, and Heinrich Göttlinger's team at Harvard Medical School in Boston, studied the interaction of HIV
with cyclophilin A in laboratory cultures.
Not exact matches
Designed assays to evaluate novel drugs,
with an emphasis on cellular pathways involving the enzymes poly - ADP - ribose polymerase, poly - ADP ribose glycohydrolase,
cyclophilins and sirtuins.