Sentences with phrase «with gene polymorphisms»
Research Paper The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta - Analysis Le Du, Lei Lei, Xiaojuan Zhao, Hongjuan He, Erfei Chen, Jing Dong, Yuan Zeng, Jin Yang J. Cancer 2018; 9 (8): 1506 - 1517.
http://www.jcancer.org/ Not exact matches
Observed parenting behaviors interact with a polymorphism of the brain - derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous — unemotional behaviors at age 3 years
Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.
A polymorphism (rs1051730) in proximity to the cholinergic receptor, nicotinic, alpha 3 (CHRNA3) gene is associated with higher tobacco consumption among smokers and can therefore be used as a genetic proxy for high tobacco consumption.
«What we found is that if people have a specific polymorphism in the BDNF gene, they recovered to a greater extent than those with a different variant of the gene.»
With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.
The team found that a single polymorphism (a difference in one «letter» of the sequence) in the BDNF gene accounted for significant differences in intelligence among those with similar injuries and comparable intelligence before being injured.
The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.
A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent.
People with the newly identified polymorphism, or form of this gene, appear to be at twice the risk of developing bipolar disorder, though it is not yet clear exactly why, says Blair.
Hill showed a single - nucleotide polymorphism — placed in the genome where a single nucleotide is altered — in this gene is «strongly associated» with elite sprint racing performance.
«These findings suggest that GCLM polymorphisms [gene variants] that affect glutathione production also affect methylmercury retention,» she wrote to me in an e-mail, «and that GSTP1 may play a role in conjugating [chemically joining] methylmercury with glutathione.»
Professor Haase also studies the relevance of genetic polymorphisms of DNA - repair and detoxification genes for AML and MDS, the relevance of iron overload for stem cell functions in MDS, and the establishment of FISH analysis of CD34 + cells from the peripheral blood as a diagnostic tool for screening and monitoring in patients with MDS.
In 2003, Nir Barzilai and Gil Atzmon, who study aging at Albert Einstein College of Medicine in New York, discovered that people with a certain polymorphism of the cholesterol - influencing gene CETP lived longer than those without it (ScienceNOW, October 2003).
Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.
Analysis of a linkage peak on chromosome 13 with a dense set of SNPs (single nucleotide polymorphisms) revealed a four - SNP haplotype spanning the gene encoding FLAP (ALOX5AP) that confers an approximately twofold increased risk of myocardial infarction, or heart attack.
The alliance will employ Illumina's platform for high - multiplex single - nucleotide polymorphism (SNP) genotyping to develop tests for gene variants deCODE has previously shown to have impact on the risk of a growing number of common diseases with major public health impact.
We conducted a two - center hospital - based case - control study with a total of 374 cases and 812 controls to assess the role of five LMO1 gene polymorphisms in the neuroblastoma risk.
The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.
Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction
Dr. Rotimi's lab has shown that a polymorphism in the endothelial nitric oxide gene is associated with diabetic retinopathy in Africans.
For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests.
PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.
It has been suggested that a high serum cholesterol level is a risk factor for (AD), and that some polymorphisms of genes encoding proteins regulating cholesterol metabolism are associated with AD development.
The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.
Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men
The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E
«The IL - 28B first came to the attention of virologists when it was shown that polymorphisms, small genetic changes, in this gene were associated with different hepatitis C virus treatment outcomes.
In a new study, Sklar and her colleagues are scanning 500,000 gene variants, known as single nucleotide polymorphisms, obtained from a sampling of patients with bipolar disorder.
As they pointed out, the repeat occurs in a region of DRD4 associated with gene activity, so the 120/240 polymorphism may have a functional effect on the dopamine receptor.
On the basis of 326,000 polymorphisms, we found low to moderate overall levels of differentiation between subspecies, and fewer than 200 genomic regions dispersed throughout the genome showing high differentiation consistent with a signature of reduced gene flow.
In contrast, variants in the MTHFR gene have been associated with increased risk of neural tube defects and cardiovascular disease; however, 60 - 70 % of individuals in the general population have one of the two most common MTHFR gene polymorphisms.
Single nucleotide polymorphisms in genes for 2» -5» - oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.J Infect Dis.
Despite this, polymorphisms in HLA genes have been shown repeatedly to be associated with susceptibility to malaria, or subcategories of the disease.
To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).
Goyal RK, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L, Livote E, Yanik G, Atlas M. Tumor necrosis factor - alpha gene polymorphisms are associated with severity of acute graft - versus - host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.
Human Gene Mutation Database; published mutations causing or associated with human inherited disease; disease - associated / functional polymorphisms.
NCBI provides Gene, Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D protein structures), dbSNP (a database of single - nucleotide polymorphisms), the Reference Sequence Collection, a map of the human genome, and a taxonomy browser, and coordinates with the National Cancer Institute to provide the Cancer Genome Anatomy Project.
No significant difference in the distribution of the investigated HNMT alleles could be shown between patients with gastrointestinal diseases and control subjects (45, 47), but a functional relevant polymorphism of the HNMT gene (chromosome 2q22) has been described for white asthma patients (48).
Although the newest edition of the authoritative textbook, Vitamin D, claims that in humans calcidiol binds with equal affinity to the DBP whether it is derived from vitamin D2 or vitamin D3, 37 the citation for this statement is the author's own PhD thesis, in which he reported results obtained from testing the DBP of a mere two people.48 Since the gene for the DBP is one of the most polymorphic known (meaning it exists in many forms), existing in three common alleles and 124 known rarer alleles (alleles are specific forms of the same gene), each allele itself having many polymorphisms, 37 a sample size of two is rather unconvincing.
The human DAO gene spans ≈ 10 kbp and is located on chromosome 7q35 (27) Various single - nucleotide polymorphisms (SNPs) in the DAO gene have been shown to be associated with inflammatory and neoplastic gastrointestinal diseases, such as food allergy (44), gluten - sensitive enteropathy, Crohn disease, ulcerative colitis, and colon adenoma (45 — 47).
The ER - beta gene +1730 G / A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS.
: To investigate whether the +1730 G / A polymorphism in the estrogen receptor (ER)- beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS).
Even more encouraging is evidence that polyphenols in olive oil can interact with a hereditary gene variant of endothelial nitric oxide synthase (the NOS3 Glu298Asp polymorphism, which is a risk factor for hypertension and coronary artery disease), to improve endothelial function after meals.19 So, even if genetics are not in your favor, olive oil may help.»
Her thesis, The MTHFR Polymorphism supported her premise that «women who are trying to get pregnant and have the MTHFR C677T gene mutation should supplement with L - methyltetrahydrofolate instead of folic acid» and is a reflection of her interest.
In fact, a recent study by Arakawa and colleagues of thyroid patients with Hashimoto's and Graves» found that polymorphisms — that is, gene variations that may lead to the abnormal expressions — were as common in autoimmune thyroid disease as they were in the normal population.
Filed Under: Events, Gene polymorphisms, Testing Tagged With: antibiotic resistance genes, anxiety, Ben Lynch, David Brady, depression, Dirty Genes, fluroquinolones, Ggenes, anxiety, Ben Lynch, David Brady, depression, Dirty Genes, fluroquinolones, GGenes, fluroquinolones, GI MAP
OBJECTIVE: To determine the frequency of the MDR1 gene mutation (polymorphism) associated with ivermectin sensitivity in a sample population of Collies in Washington and Idaho.
Methods.: Dogs of various breeds, affected or unaffected with primary glaucoma, were genotyped for the Gly661Arg variant of ADAMTS10, as well as 7 other nonsynonymous single nucleotide polymorphisms (SNPs) in other genes in the beagle POAG locus that segregate with disease.
DRD4 and TH gene polymorphisms are associated with activity, impulsivity, and inattention in Siberian Husky dogs.