Not exact matches
The study included 121 people from Japan and 252 from Australia, and both groups involved individuals
with normal brain
function, mild
cognitive impairment and Alzheimer's.
The findings, published in the journal Nature Neuroscience, could help explain how some older adults
with beta - amyloid deposits in their brain retain
normal cognitive function while others develop dementia.
Of the participants, 69 had
normal cognitive function at the start of the study, 52 had been recently diagnosed
with mild
cognitive impairment, and 31 were diagnosed
with Alzheimer's disease.
BDNF, a target gene of CREB, is reduced
with age and in the AD brain [112] and is required for
normal cognitive function [113].
With this goal in mind, Nakashima and his collaborators will next examine whether voluntary exercise improves
cognitive functioning by restoring the
normal balance of excitatory and inhibitory signals in the hippocampus.
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The participants selected had to have similar physical ability, assessed
with the activities of daily living (ADL) score, and
normal cognitive function or only mild
cognitive disturbance as defined by a Mini-Mental State Examination > 20 (18).
That means I need to find ways to increase BDNF more than in someone
with the
normal gene in order to preserve my
cognitive function, memory, and emotional regulation.8 Mu, J.S., et al. «Deprivation of Endogenous Brain - Derived Neurotrophic Factor Results in Impairment of Spatial Learning and Memory in Adult... continue 9Cirulli, F., et al. «Intrahippocampal Administration of BDNF in Adult Rats Affects Short - term Behavioral Plasticity in the Morris Water Maze and... continue