Sentences with phrase «with synaptic plasticity»

Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T. (2016) Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.

This is called homeostasis, and I've been studying that along with the synaptic plasticity associated with learning and memory.

Not exact matches

Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory synaptic connections with activity and experience, is thought to play a critical role in memory storage.

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

«The new growth rule provides structural plasticity with a principle that is almost as simple as that of synaptic plasticity,» says co-author Arjen van Ooyen, who has been working on models for the development of neural networks for decades.

Modulation of an NCAM - related adhesion molecule with long - term synaptic plasticity in Aplysia

In fact, compared with ethanol, which enhances synaptic plasticity only after long - term use, «stress can do the same job more rapidly,» Morikawa says.

Moser's approach — risky at the time, he says — merged psychology with physiology, investigating synaptic plasticity by recording neural signals from intact mammalian brains.

Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin - dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.

Moreover, in conjunction with these results, they found decreased protein synthesis, known to be required for long - term potentiation — a form of long - lasting synaptic plasticity — and for long - term memory.

It has been known for decades that triggering new protein synthesis is vital to the formation of long - term memories as well as for long - lasting synaptic plasticity — the ability of the neurons to change the collective strength of their connections with other neurons.

Since morphology changes of synapses underlie synaptic plasticity and our learning and memory, this will provide us with many new insights into mechanisms of how neurons store information in their morphology, how it changes synaptic strength and ultimately how it creates new memory.

«Our research shows that combination treatment with the two compounds can promote resilience against stress - mediated depression - like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,» says Jun Wang, PhD, Associate Professor of the Department of Neurology and first author on the paper.

Describing the association of morphological changes in dendritic spines with long - term synaptic plasticity

Based on evidence from electrophysiological studies showing that both synaptic plasticity and strength of inputs to hippocampal region CA1 vary systematically with ongoing theta oscillations (Hyman et al., 2003; Brankack et al., 1993), it has been suggested that the theta rhythm functions to separate periods of encoding of current sensory stimuli and retrieval of episodic memory cued by current stimuli so as to avoid interference that would occur if encoding and retrieval were simultaneous.

With this technique we can study synaptic plasticity at its most fundamental level.

The rise in C3 protein level correlated with decreases in synaptic puncta and synaptophysin densities and synaptic protein, neuron loss, and reduced synaptic plasticity.

Using these approaches in combination with genetics, molecular biology and biochemistry, we are studying the molecular mechanisms underlying synaptic transmission and plasticity in mammalian central nervous system.

University home > Centre for Synaptic Plasticity > Proteins interacting with glutamate receptors > AMPAR interactors

We have previously shown ex-vivo its beneficial effect on synaptic transmission and plasticity in a mouse model of the OPHN1 loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and spatial memories are partially or not rescued by the treatment.

One problem that has been difficult to address with existing tools is the role of NMDA - Rs in cocaine - induced synaptic plasticity.

«These experiments with cell type - specific pharmacology provide direct evidence for the necessity of NMDA - Rs in dopamine neurons for the synaptic plasticity observed 3 - 5 hours after exposure to cocaine in vitro, leaving open the molecular explanation for the potentiation AMPA - Rs that occurs after many days of NMDA - R inactivity in dopamine neurons in vivo.

a) In the subsection «Cell type - specific NMDA - R pharmacology in cocaine - induced synaptic plasticity» we now more clearly introduce the Zweifel and Engblom studies as well as the differences between them: both of which used genetic ablation of Grin1 over 1 week but showed different results with respect to DA neuron synaptic potentiation, which was due to methodological challenges with AMP - R compensation.