Sentences with phrase «with abnormal chromosomes»
High DDT and PCB exposure during adolescence and adulthood is associated with abnormal chromosomes in sperm
https://www.scientificamerican.com/ Not exact matches
Certain genetic abnormalities are present; some boys are born with an abnormal Y chromosome and they'll never produce normal sperm; even though they're normal males, they just don't have normal sperm production.
Poorer quality embryos and those with chaotic, abnormal chromosome rearrangements are unable to do this properly and stop dividing.
Previous research suggests sperm with an abnormal amount of chromosomes may lead to failed pregnancies and birth defects.
Abnormal number of chromosomes is often associated with cancer development.
An oocyte with decreased Topoiosmerase II levels in heterochromatic region of the X chromosome (green) failed to separate while heterochromatic region of the 4th chromosome (red) is stretched into abnormal projections.
Then she learned that people with 22q duplication — abnormal repetition, or duplication, of genetic material in chromosome 22 — had learning delays and sometimes autism, but a lower risk for schizophrenia than that found in the general population.
As with most cancers, triple - negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.
Li points out that, unlike yeast cells, human and mammalian cells have a protein called p53 that kills cells with abnormal numbers of chromosomes.
UroSEEK uses urine samples to seek out mutations in 11 genes or the presence of abnormal numbers of chromosomes that would indicate the presence of DNA associated with bladder cancer or upper tract urothelial cancer (UTUC).
According to Reeves, the result suggests that genes in the DSCR make their mischief by interacting with other abnormal genes far away on chromosome 21, and that the genetics of Down syndrome are probably more complex than has been generally thought.
Eight physicians and three fellows evaluate and treat children with diabetes, growth disorders, precocious and delayed puberty, sex chromosome disorders (particularly Turner syndrome), abnormal bone development, and other hormonal problems.
«In fact, abnormal cells with numerical and / or structural anomalies of chromosomes have been observed in as many as 80 - 90 % of human early stage embryos following in vitro fertilization,» says Professor Thierry Voet from the Wellcome Trust Sanger Institute, UK, and the University of Leuven, Belgium, another senior author of this paper, «and CSV tests may expose some degree of these abnormalities.»
Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??
How do meiocytes recognize if chromosome pairing fails, how do they correct such errors, and how defective meiocytes are eliminated, in order to avoid the formation of gametes with aneuploidy / abnormal genomes?
We are particularly interested in the mechanism of chromosome pairing and the quality control of the crossover formation process, and we aim to understand how the formation of gametes with abnormal / aneuploid genome is minimized in mammals.