Sentences with phrase «with abnormal proteins»

These can then trigger normal proteins to also misfold, producing a chain reaction that clogs the brain with abnormal proteins and so causing diseases such as vCJD.

Not exact matches

In an interview, the Glasgow - based neurologist described how he had examined sections of brain tissue in a retired rugby player and found abnormal proteins associated with head injuries and dementia.

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

The researchers worked through the symptoms of the disease, matching each one with abnormal levels of proteins from the biopsies, and then with existing drugs that could potentially provide relief.

At the Gladstone, cardiovascular scientist Robert Mahley, working with a team including neuroscientist Yadong Huang, has identified small «corrector» molecules that modify the structure of ApoE4 protein to one more like that of ApoE3, thereby reducing abnormal fragmentation.

Payne keyed in the symptoms, and the computer program suggested a handful of potential conditions, including a rare disease called amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and causing nerve damage.

People with the transthyretin amyloidosis have mutations in the DNA of the transthyretin gene, which causes abnormal buildup and deposits of a transport protein called transthyretin in nerve and heart cells.

Liu notes that this abnormal protein secretion occurs in other parts of the body as well with exfoliation syndrome, but appears to be problematic only in the eye.

Most people associate prion diseases with the brain, although scientists have found abnormal infectious prion protein in other organs, including the spleen, kidney, lungs and liver.

They mixed normal protein tagged with a radioactive label with unlabelled abnormal protein, and two days later were able to detect tagged abnormal protein.

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.

Studies in mice specially bred to have features of the disease found that DHA reduces beta - amyloid plaques, abnormal protein deposits in the brain that are a hallmark of Alzheimer's, although a clinical trial of DHA showed no impact on people with mild to moderate Alzheimer's disease.

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

These abnormal proteins are prone to aggregating with one another inside cells.

Li points out that, unlike yeast cells, human and mammalian cells have a protein called p53 that kills cells with abnormal numbers of chromosomes.

In the current study, Dr. Santambrogio and her colleagues looked for abnormal accumulations of proteins in the synovial fluid (which bathes the joints) and blood of patients with JIA.

Mice that are missing this pruning protein wind up with disorganized, abnormal retinas.

A mutation in either gene causes it to combine with a partner gene to express an abnormal fusion protein that acts along a cellular growth pathway to result in cancer.

Then he medicated the animals with AZD - 4547, an experimental drug that targets the abnormal proteins.

The disease is largely attributed to an abnormal buildup of proteins, which can form amyloid beta plaques and tangles in the brain that trigger inflammation and result in the loss of brain connections called synapses, the effect most strongly associated with cognitive decline.

Other genetic defects associated with hypertrophic cardiomyopathy — six different genes have been linked to the disease — may work similarly by producing abnormal proteins involved in contraction, says Sweeney.

Abnormal levels of the proteins may be useful biomarkers that could help us study early treatments to limit or reverse the damage to brain cells and even prevent the development of the full - blown disease,» said study author Edward Goetzl, MD, a Professor of Medicine with the University of California, San Francisco, a researcher at the National Institute on Aging, and a scientist of NanoSomiX, Inc., a California - based biotechnology company that provided a grant for method development for the study.

If the reporter happens to bind to other surfaces, or other proteins, she said, it can indicate an abnormal concentration of target proteins that correlate with a disease.

Working with Tanz researcher Tetsuro Murakami and with colleagues at the University of Cambridge and Columbia University, they focused initially on the FUS protein, and discovered that these abnormal clumps could actually be a very important player in causing nerve cell damage and ALS.

The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate - forming protein «huntingtin» of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway.

Intriguingly, brain cells (neurons) with decreased complex I levels are significantly less likely to contain Lewy bodies, the abnormal protein - aggregates that characterize Parkinson's disease,» says researcher Charalampos Tzoulis at Department of Clinical Science, UiB.

The researchers also found evidence suggesting that the abnormal tau protein was moving from neuron to neuron across synapses, the junctions that these cells use to communicate with each other.

A new study by Columbia University Medical Center (CUMC) researchers strongly supports the latter, demonstrating that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer's, propagates along linked brain circuits, «jumping» from neuron to neuron.

R6 / 2 mice have been genetically altered with an abnormal gene that makes them produce a harmful fragment of the mutant huntingtin protein

Lewy bodies (accumulation of abnormal alpha - synuclein A protein in the human brain that is associated with the development of Parkinson's.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

Deep inside the brains of people with dementia and Lou Gehrig's disease, globs of abnormal protein gum up the inner workings of brain cells — dooming them to an early death.

Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).

«The strong evidence that abnormal TDP - 43 protein is involved in the development of ALS, coupled with models that may replicate ALS more faithfully than other tools, may speed development of therapies for the thousands of individuals diagnosed with this devastating disease.»

A diet lacking in protein can shut down hair growth, reduce its quality and result with abnormal hair loss.

Earlier lab work by the researchers helped explain key mechanisms involved with assisting vitamin D3 to clear the abnormal protein amyloid - beta, which is found within the plaque.

Cachexia is characterized by an ongoing loss of skeletal muscle mass due to abnormal metabolism and protein catabolism, thought mostly to be associated with chronic inflammation.

Also Paul, I was diagnosed with MGUS (an abnormal protein in the blood)(Immunoglobulin M spike level) a year ago, however, was pleased to see that my MGUS score come down this last month.

In previous articles I've pointed out that protein supplements are evolutionarily novel food products with an abnormal nutrient composition and that the consumption of the most popular type of protein supplement on the -LSB-...]

Sometimes, however — particularly as we age, and when we consume too many sugary or high - glycemic foods — these sugars react with proteins and fats in an abnormal way, producing harmful molecules called «advanced glycation endproducts (conveniently acronymned: AGEs).»

TPE is an apheresis (removal of impurities from blood) treatment in which plasma contaminated with damaging auto - antibodies, toxins or abnormal proteins is separated from the patient's flowing blood and exchanged with donor plasma that is returned to the patient to render the patient less susceptible to or free from immunologic attack or other pathologic processes.

Recent studies have linked osteoarthritis occurrence and progression with an abnormal response of the immune system to exposed cartilage proteins.

The ability of colchicine to interfere with this sort of structural protein formation has led to its use in abnormal protein depositions such as amyloidosis.

Dogs with multiple myeloma may have high blood calcium and abnormal protein in the urine.

Abnormal proteins, called «amyloid» build up and inhibit brain cell function, particularly in brain regions involved with complex thought and memory.

Cataracts are an abnormal cloudiness of the lens caused by a buildup of protein or pigment in the lens which interferes with normal vision.