Sentences with phrase «with additional cancer»

The researchers want to combine the switch with some additional cancer - fighting weapons they envision engineering into T - cells.

Other recent studies have recognized HCV's increased association with additional cancers, says Torres, but there was no known association with a significant number of head and neck cancers.

Not exact matches

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

In particular, sales of prostate cancer treatment Zytiga and anti-immune biologic Stelara grew the most in pure dollar terms, with the U.S. Food and Drug Administration having approved an additional indication for Zytiga to help boost its revenue.

The new Critical Illness Benefit provides consumers with additional financial protection when faced with a serious medical diagnosis, such as a heart attack, cancer or stroke.

I hope that Governor Cuomo will sign this law as soon as possible to expand the Volunteer Firefighters» Benefits Law to include additional forms of cancer that are connected to the hazardous materials that volunteers come in contact with while on duty.

Grants to fund additional work were denied, Wilson was diagnosed with cancer (he died in 1991), and the project was shelved.

«With this discovery in our hands, we'd now like to try to find out which additional immune - cell properties cancer cells have and study how they affect the metastatic process,» says Dr Fuxe.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

Scientists developed an improved vaccine called 9vHPV that targets HPV 16, 18, 6, and 11, and an additional 5 HPV types that are the next most commonly associated with cervical cancer (HPV 31, 33, 45, 52 and 58).

«When cancer comes back, it's genetically very similar to the original tumor but often with additional mutations that may give cancer cells new strategies to survive attack by whatever drugs are thrown at them.

The findings of this study may be useful for planning future support programs for cancer patients, and can provide additional information to guide programs for people with specific cancer types.

The results of this trial are encouraging and deserve additional testing prior to becoming a standard of care for patients with advanced pancreatic cancer.

Specifically, they found that chemotherapy alone leads to two types of dormant cancer cells that are not killed outright and become resistant to additional chemotherapy, but when combined with immunotherapy, a majority of dormant cells also is destroyed.

«Recent studies have reported supplemental cancer detection rates of 1.9 per 1,000 women screened with automated whole breast ultrasound and 1.2 to 2.8 per 1,000 women screened with digital breast tomosynthesis, so our finding of an additional 8.8 cancers per 1,000 women makes MBI a very compelling option for women who elect supplemental screening,» says Dr. Rhodes.

In our day and age, when growing numbers of women of reproductive age are diagnosed with thyroid cancer and when fertility problems are rampant, these findings should serve as an additional consideration for physicians contemplating radioactive iodine for their patients,» said senior author Karen Tordjman, MD, associate professor of medicine at the Sackler Faculty of Medicine of Tel Aviv University.

Interestingly, IBS biologists uncovered additional miRNA end modifications after DROSHA processing, which are expected to be important for the regulation of miRNA biogenesis, whose dysregulation is often associated with diseases, in particular with cancer.

Data collected during a long - term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists Dominique Michaud at Tufts University School of Medicine and Elizabeth Platz of the Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer Ccancer in individuals with advanced gum disease, according to a new collaborative study led by epidemiologists Dominique Michaud at Tufts University School of Medicine and Elizabeth Platz of the Johns Hopkins Bloomberg School of Public Health and Kimmel Cancer CCancer Center.

The finding may help scientists unravel a paradox: Cells with extra chromosomes grow slower than cells with the usual two copies of each chromosome, but cancer cells, which grow quickly, often have additional chromosomes.

On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive.

If a woman with a strong family history of breast and ovarian cancers tests negative for the BRCA1 / 2 genes, that does not mean her relatives are not at risk, says Daly — her siblings could still carry the gene, or there could be additional genes present that predispose them to cancer that clinicians don't yet know how to test for.

«I believe we have an opportunity to investigate and equip men with additional tools above and beyond surgical intervention that can help them manage cancer - related uncertainty intolerance,» Victorson said.

The period of time before ovarian cancer recurred (called progression - free survival) improved by nearly 3.5 months with the additional drug (13.8 months compared with 10.4 months for the woman on chemotherapy alone).

Each additional serving per day of red meat was associated with a 13 % increase in risk of breast cancer (12 % in premenopausal and 8 % in postmenopausal women).

Velculescu cautions that medical practice may not change much until additional studies validate their findings, and there are ongoing clinical trials studying the removal of fallopian tubes instead of ovaries in women with cancer - causing, hereditary BRCA1 and BRCA2 mutations.

An additional set of 18 prostate cancer tissue samples was analyzed by qPCR and five lncRNAs were found to be significantly higher in prostate tumor tissues compared with matched normal tissues.

Because some intermediate - risk prostate cancer patients were included in the study, a current analysis was conducted to determine if patients in the intermediate - risk subset experienced an additional survival benefit with LTAD.

Longer term, they want to quickly diagnose additional cancer types, including ovarian and pancreatic cancers, which are fast - spreading and require early detection for a patient to survive, says Goda, who was recently appointed as a chemistry professor at the University of Tokyo but will continue his research with U.C.L.A..

They were interested in determining what types of secondary, additional changes occur in primary BRCA1 / 2 germline mutation - associated cancers that might act in concert with BRCA1 and BRCA2 to drive the cancers.

The identification of patients with high - risk breast cancer is key to knowing whether a patient will require only the removal of the tumor by surgery or whether if she will need additional chemotherapy to make sure the removal of breast cancer cells.

Additional sequencing led the researchers to identify a previously unknown mutation on the X-chromosome that may be associated with cases of ovarian cancer that develop more than 6 years earlier that average.

These PARPis, along with 2 others (talazoparib and veliparib), are being evaluated for their potential to treat additional malignancies, including prostate cancers.

In order to determine whether reduced miR - 192 levels are only a chance side effect of cancer and inflammation or whether they in fact influence tumor progression, the investigators equipped pancreatic cancer cells with additional miR - 192.

The NYGC and its founding member institutions are conducting additional studies involving Watson to help accelerate the discovery of potentially actionable sequence variants in various types of cancer, including an ongoing study that involves DNA and RNA from a larger cohort of glioblastoma patients, and a study of 200 patients with different types of cancer.

«We're recommending that we do an additional trial to confirm these results and see how it would extend to other populations,» says Clark, in particular women and those with certain cancer types.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

«The management of patients with elevated or borderline PSA continues to be a challenge, and having the additional knowledge of a patient's genetic risk for prostate cancer can be very useful.

We have one of the most comprehensive CAR T cell programs in the world, with 14 CAR T clinical trials ongoing and plans to open numerous additional trials in the coming year, including for patients with multiple myeloma, prostate cancer, liver cancer and breast cancer.

Additional evidence supporting the tumor - promoting role of inflammation is the observation that individuals with chronic inflammation are more susceptible to cancers at the site of that inflammation — e.g. patients with Crohn's disease show increased incidence of colorectal cancer.

The nationally recognized Rutgers Cancer Institute of New Jersey has joined forces with a major teaching hospital in Newark to expand opportunities for cutting - edge patient care, research, and cancer education in the state's largest city — which officials said is particularly hard - hit by cancer and could especially benefit from additional treatment opCancer Institute of New Jersey has joined forces with a major teaching hospital in Newark to expand opportunities for cutting - edge patient care, research, and cancer education in the state's largest city — which officials said is particularly hard - hit by cancer and could especially benefit from additional treatment opcancer education in the state's largest city — which officials said is particularly hard - hit by cancer and could especially benefit from additional treatment opcancer and could especially benefit from additional treatment options.

Additional trials utilizing this vaccine are ongoing in glioblastoma, while a vaccine and checkpoint immunotherapy combination trial is being planned for patients with bladder cancer.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic developmWith the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic developmwith gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

Years later, Wharam oversaw two additional expansions, one with the opening of the Kimmel Cancer Center's Harry and Jeanette Weinberg Building and another with a satellite facility at Green Spring Station.

examines long - term sequelae resulting from a diagnosis of childhood cancer and its treatment, and health care relating to these late effects.This multi-study initiative is funded by a Canadian Cancer Society program project grant, with additional funding from CCS BC and Yukon Division, and has examined long - term health effects and educational attainment, health care utilization, and quality of follow - up care among disease survcancer and its treatment, and health care relating to these late effects.This multi-study initiative is funded by a Canadian Cancer Society program project grant, with additional funding from CCS BC and Yukon Division, and has examined long - term health effects and educational attainment, health care utilization, and quality of follow - up care among disease survCancer Society program project grant, with additional funding from CCS BC and Yukon Division, and has examined long - term health effects and educational attainment, health care utilization, and quality of follow - up care among disease survivors.

Based on these promising results, an additional 110 patients with advanced head and neck cancer are being recruited to the study.

This gene finding may allow scientists to identify patients with this aggressive form of the cancer and target them with additional therapies.

More recently, additional groups of samples from patients with prostate cancer have been examined for the presence of XMRV with both positive [5] and negative [6, 7] results.

After adjusting for common factors that influence breast cancer risk, Henderson and colleagues found that women whose mammograms were classified as false - positive who were referred for additional imaging had a 39 percent increased chance of developing subsequent breast cancer during the 10 - year follow - up period, compared with women with a true - negative result.

There are two parts to this study: - Phase Ib: To determine the safety and side effects of increasing doses of IL - 2 in combination with pembrolizumab - Phase II: Once the maximum tolerated dose of IL - 2 is determined, additional patients will be treated to determine if it is effective against the cancer.

The personalized test can tell if a person is cured with surgery or if there are cancer cells left behind that will require additional treatment, monitor the progression of each person's cancer and its response to treatment, and alert clinicians to a recurrence of disease.