Sentences with phrase «with additional mutations»

«When cancer comes back, it's genetically very similar to the original tumor but often with additional mutations that may give cancer cells new strategies to survive attack by whatever drugs are thrown at them.

Not exact matches

The authors conclude by raising what they consider to be «a broader ethical problem with OAR,» stating that this procedure amounts to nothing more than human cloning with the additional twist of introducing a genetic mutation» ominously concluding that a «combination of wrongs can not make the end result good.»

He infected ferrets with the hybrid virus, which then acquired two additional mutations.

However, Shih says, he and his team are working on additional studies to determine if the mutations correlate with patients» outcomes.

The Oxford researchers turned back from the boy to the KE family and, using the additional information, discovered that those members with language troubles shared a mutation in FOXP2 as well.

The authors will follow up the study with additional worldwide populations to better understand the mutations and these genes as a genetic marker for disease risk.

Since whole - brain radiation is associated with significant cognitive effects and the use of additional radiation therapy for progression is common in this population, the Yale researchers suspect that patients with the ALK mutation would benefit from radiation focused on individual metastases.

They are also working with additional collaborators, including the New York Genome Center, to sequence approximately 500 more Ashkenazi genomes to make the catalog of mutations even more comprehensive.

However, not all dogs with the mutation became affected, prompting the hypothesis that additional genes could modify disease risk.

Kawaoka's group carried out a series of experiments that coaxed out additional mutations with that effect.

Velculescu cautions that medical practice may not change much until additional studies validate their findings, and there are ongoing clinical trials studying the removal of fallopian tubes instead of ovaries in women with cancer - causing, hereditary BRCA1 and BRCA2 mutations.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

They were interested in determining what types of secondary, additional changes occur in primary BRCA1 / 2 germline mutation - associated cancers that might act in concert with BRCA1 and BRCA2 to drive the cancers.

Additional sequencing led the researchers to identify a previously unknown mutation on the X-chromosome that may be associated with cases of ovarian cancer that develop more than 6 years earlier that average.

Additional experiments with cultured cells suggested that the mutation interferes with one of the enzymes that breaks down the APP protein and causes a 40 % reduction in β amyloid formation, Stefansson and colleagues report online today in Nature.

An additional 6 isolates with varying morphotypes retrieved from the UK HPA reference library will also be sequenced and compared for further identification of mutations that may lead to morphology differences.

[41] Approximately 50 % of cutaneous melanomas have an activating BRAF mutation, with an additional 10 % to 20 % having an activating mutation in NRAS; NRAS is an upstream partner of BRAF that also activates the phosphatidylinositol 3 - kinase (PI3K) / Akt / mammalian target of rapamycin (mTOR) pathway.

We could also quantify this contribution, noting that the expected number of sun - related mutations associated with an MC1R variant is comparable to the number gained in about 21 additional years of age.

Fortunately, experiments done by Dr. Jan Vijg at the Albert Einstein College of Medicine and others on mutations (changes in base sequence in DNA) and additional studies commissioned by SENS Research Foundation on epimutations (changes in the arrangement of methyl groups) suggest that these latter kinds of alterations - the kind that accumulate in cells without triggering apoptosis or senescence or contributing to cancer - accumulate too slowly to make a difference with the current lifespan.

The goal of our research is to provide doctors with key, additional information to choose best treatment strategies for breast cancers with novel mutations of unknown significance.

Derivatives of this basic construct included removal of the alternative exon 4 by deleting an Nhe I / Apa I fragment (nucleotides 12,259 — 12,543; Figure 3D); replacement of the genomic region covering exons 2 — 6 with the corresponding cDNA sequence (Sal I to Nco I; nucleotides 14,412 — 11,736; Figure 3E) plus additional upstream sequence to allow for recombination with F56B12 (to the Xho I site at nucleotide 15,574); and introduction of a Met to Leu mutation (M121L, ATG to CTG) by PCR amplification with primers that included the sequence change (nucleotides 11,968 — 11,970; Figure 3F).

Here, we report a total of seven patients (six patients identified through the Wellcome Trust Deciphering Developmental Disorders study, with one additional patient), who have heterozygous de novo mutations in HNRNPU.

In these analyses, we identify and subsequently analyze a set of 107 autosomal genes with a false discovery rate (FDR) of < 30 %; in total, this larger set of genes harbor de novo loss of function (LoF) mutations in 5 % of cases, and numerous de novo missense and inherited LoF mutations in additional cases.

I was born with polydactyly; a mutation that gave me an additional digit jutting out of each of my pinky fingers.

Together these findings suggest that additional mutations are involved which modify the age of onset of ophthalmoscopic abnormalities associated with the RPGRIP1 mutation.