Sentences with phrase «with aggressive tumors»

About 50 percent to 70 percent of patients with aggressive tumors do not respond to standard chemotherapy and suffer recurring tumors, Berry said.

But many children with aggressive tumors — like 4 - year - old Damian Salgado, who Berry treated in 2015 — still lose eyes.

BRAF mutations, which occur in about 40 to 50 percent of these patients, have been associated with aggressive tumors and decreased ability of tumors to respond to radioactive iodine, typically the first line of treatment in these patients.

Studies show that human cancer cells express high levels of the fatty acid synthase enzyme, which is associated with aggressive tumor behavior and tumor - cell growth.

Not exact matches

In 2009 he had been diagnosed with a type of rapidly growing brain tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved into a glioblastoma — the highly malignant brain tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.

Arizona Sen. John McCain, 80, was diagnosed with an aggressive brain tumor — glioblastoma — following an earlier craniotomy to remove a blood clot from above his left eye, the Mayo Clinic Hospital in Phoenix said.

Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often associated with a gloomy prognosis.

While there have been improvements in the current standard treatments, patients with glioblastoma (GBM), the most common and aggressive form of brain tumor, still suffer from a median survival rate of only 14.6 months and 5 - year overall survival rates of less than 10 %.

«Study identifies potential treatment target for pancreatic cancer: Molecular signature found in 30 percent of PDAC tumors associated with more aggressive cancer.»

A Gleason score of < 6 typically indicates a less aggressive tumor with generally good prognosis.

Glioblastoma is the most aggressive type of tumor that originates in the brain and with no curative treatments currently available, the average survival time for patients ranges from 15 to 18 months.

«Aggressive cancers contain regions where the cancer cells are starved for oxygen and die off, yet patients with these tumors generally have the worst outcome.

Importantly, elevated BRCA1 methylation was confined to patients diagnosed with so - called high - grade serous tumors, the most aggressive variant of ovarian cancer, which also is the variant associated with BRCA1 mutations.

Because of this lack of receptors, common cancer drugs can't «find» the cells, and doctors must treat the cancer with extremely aggressive and highly toxic treatment strategies,» said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center.

Recently, teaming up with co-investigator Associate Professor Dr. Rolf A. Brekken, they looked into its possible involvement in Pancreatic Ductal Adenocarcinoma (PDA), the most common form of pancreatic cancer, in a mouse model with an early onset aggressive form of tumor development.

Patients with aggressive neuroendocrine tumors (NETs) have limited treatment options and there are few oncologists who are specialised in this relatively rare disease.

«We found a striking difference between the metabolic profiles of poorly aggressive and highly aggressive ovarian tumor cells, particularly with respect to their production and use of the amino acid glutamine,» said lead researcher Deepak Nagrath of Rice.

The team chose to compare breast tissue from healthy individuals with tumor samples taken from breast cancer patients — including both primary tumors that had not spread from the breast to other body sites, and highly aggressive, metastatic tumors.

In tests in mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a week.

Participants with high levels of TCEP in their house dust were more than four times as likely to have larger, more aggressive tumors that extended beyond the thyroid, according to the study.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

Chimeric antigen receptor (CAR) T cell therapy, which edits a cancer patient's T cells to recognize their tumors, has successfully helped patients with aggressive blood cancers but has yet to show the ability to treat solid tumors.

The team collected tumors from 68 women affected with ovarian and uterine CSs to try to determine the molecular basis of the tumor's aggressive behavior.

Oncologists have long known that in rare cases, after patients receive radiation therapy to shrink a tumor, the immune system will mount an aggressive response that wipes out not only the tumor, but metastases throughout the body that hadn't been treated with the radiation.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.

In their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrence.

A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character — from aggressive to static, and no longer shedding cells that can colonize distant organs of the body.

For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA.

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

Findings published in Oncotarget offer new hope for children with highly aggressive brain tumors like atypical teratoid / rhabdoid tumor (AT / RT) and medulloblastoma.

Certain kinds of tumors have been found to be more aggressive and associated with less than favorable prognoses compared to others.

As this variant also appears to be associated with the development of more aggressive prostate tumors, a diagnostic test for the variant may enable doctors to make more informed decisions as to how closely they should monitor those who are at high risk, and how aggressively they should treat the disease once it presents.

For a majority of patients diagnosed with aggressive, high - grade tumors with metastases, the five - year survival rate is about 16 percent, though chemotherapy has been associated with an improvement in survival, and new targeted agents are being tested.

However, unfortunately the mechanisms of tumor cells have the ability to resist to immunotherapy and patients who relapse with acquired resistance to BRAF and MEK inhibitors often present with melanomas that display a much more aggressive and invasive phenotype [13, 14].

«With 100 million mutations, each capable of altering a protein in some way, there is a high probability that a significant minority of tumor cells will survive, even after aggressive treatment,» said study director Chung - I Wu, PhD, professor of ecology and evolution at the University of Chicago.

The researchers found that non-Hispanic white women were more likely to have smaller tumors, and more likely to have the less - aggressive HR + / HER2 - subtype of breast cancer, compared with African - American women, who were more likely to have large tumors, more likely to have the aggressive triple - negative breast cancer, and 40 to 70 percent more likely to be diagnosed at stage 4 of all subtypes of breast cancer.

Rudensky's team compared Tregs in normal human breast tissues with those found in untreated breast tumors, and found that Tregs in tumors were capable of more potent and aggressive immunosuppressive action.

Scientists exploit gene therapy to shrink tumors in mice with an aggressive form of breast cancer.

Consequently, most patients with advanced disease have died from a local recurrence of their tumor, even after aggressive treatment.

Since completing the initial paper published Thursday, the team has analyzed 50 more samples from eye fluid of retinoblastoma patients, including those with less aggressive tumors whose eyes were saved, to get a start on determining what factors might be at play in tumor progression.

Although some tumors may be formed by initiating cells that do not resemble stem cells, it is likely that stem cell — like tumor cells are more aggressive at forming tumors, with a higher likelihood of relapse and metastasis.

December 13, 2011 Molecular markers can predict spread of cancer, guide treatment Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from aggressive, targeted radiation therapy.

And another one in rodents with lung cancer published in Science Translational Medicine in 2014 found that normal doses of vitamin E and smaller doses of acetylcysteine, an antioxidant supplement, appeared to lead to a three-fold increase in the number of tumors and caused them to be more aggressive.

Tumor - targeting nanoparticles loaded with a drug that makes cancer cells more vulnerable to chemotherapy's toxicity could be used to treat an aggressive and often deadly form of endometrial cancer, according to new research...

May 16, 2018 • An aggressive type of breast cancer — a HER2 - positive tumor — often shrinks with Herceptin treatment, but side effects can be tough.

Even with aggressive surgery, the tumor recurrence rate is very high (at least 50 % by 6 months after surgery).

Nasal carcinomas are locally aggressive tumors with a low to moderate metastatic rate.

Our patient of the month is Susie, a 10 year old spayed female mixed breed dog who was presented to our VRCC Oncology department in January 2008 with a diagnosis of an aggressive sweat gland tumor located on her muzzle.

«Basosquamous carcinoma» (basal cell tumor with areas of squamous cell differentiation) is more aggressive than most basal cell tumors.