One third of these mice developed severe hepatic steatosis (infiltration of liver cells with fat), neutrophil infiltration, and necrosis, similar to that seen in patients
with alcoholic hepatitis.
After excluding hepatitis - B infected and HIV - positive subjects, researchers reviewed the charts of 791 ALD patients, including 130 with alcoholic fatty liver, 154
with alcoholic hepatitis, and 507 with alcoholic cirrhosis.
In collaboration with Indiana University and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), Intercept is supporting a blinded Phase 2 trial treating 60 patients
with alcoholic hepatitis (NCT02039219 on clinicaltrials.gov).
«
Alcoholic liver disease is a spectrum of conditions that range from hepatic steatosis, which is fat deposition in the liver and it is reversible with sobriety, to alcoholic hepatitis which is a more severe condition characterized by extensive and severe inflammation in the liver and often requires hospitalization,» explained Valentina Medici, associate professor of internal medicine at UC Davis Health System as well as corresponding author for t
Alcoholic liver disease is a spectrum of conditions that range from hepatic steatosis, which is fat deposition in the liver and it is reversible
with sobriety, to
alcoholic hepatitis which is a more severe condition characterized by extensive and severe inflammation in the liver and often requires hospitalization,» explained Valentina Medici, associate professor of internal medicine at UC Davis Health System as well as corresponding author for t
alcoholic hepatitis which is a more severe condition characterized by extensive and severe inflammation in the liver and often requires hospitalization,» explained Valentina Medici, associate professor of internal medicine at UC Davis Health System as well as corresponding author for the study.