Sentences with phrase «with alkenes»
The rhodium azavinyl carbenes react with alkenes, yielding cyclopropanes or dihydropyrroles with good stereoselectivity.
https://cen.acs.org/
It is now well known that a systematic replacement of the planar peptide bond with an alkene bioisostere is useful for the estimation of the electrostatic effects and for the SAR evaluation of peptide derivatives.
Not exact matches
All chemists are well - acquainted with alkanes, alkenes and alkynes, which have single, double and triple carbon - carbon bonds respectively.
Both (E)- alkene and (Z)- fluoroalkene analogues (5 and 6) with substitutions at the Arg2 - Arg3 dipeptide moderately inhibited SDF - 1 binding to CXCR4 with IC50 values of 1.46 and 1.78 μM, respectively.
The replacement of the Arg3 - Nal4 peptide bond with an (E)- alkene isostere in compound 7 produced a negative effect on CXCR4 inhibitory activity, probably due to the lack of H - bonding of amide moiety and a different interaction of pseudo -1,3-allylic strain between the Arg3 carbonyl group and the Nal4 side chain.