Sentences with phrase «with allelic»

Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity

More importantly, however, it will be crucial to determine (1) how this functional locus interacts with the allelic expression imbalance markers downstream (and which the actual locus conferring allelic expression imbalance is, see in what follows)(2), what the relative contribution to a net effect on serotonin transporter gene expression is in vivo and (3) how (if at all) this translates into protein abundance and actual genetically determined differential functioning of the serotonergic synapse.

Not exact matches

Human diseases with the largest public burden are E / LS dependent diseases, and the team found that allelic distributions for them follow that for an average human SNP which is neutral.

The authors conclude that»... by 4400 years ago, early farmers had already had a substantial homogenizing effect on allelic diversity at three genes associated with maize morphology and biochemical properties of the corn cob.»

Contrary to expectations, autosomes had equal allelic contributions from the eight founders, but chromosome X had significantly lower allelic contributions from the two inbred founders with underrepresented subspecific origins (PWK / PhJ and CAST / EiJ).

Many of the allelic effects in the QTL were driven by the two founders with underrepresented subspecific origins, including a QTL on chromosome X for infertility that was driven by the PWK / PhJ haplotype.

Secondly, highlighting the potential relevance of current findings to all diploid organisms including humans was the observation that in one compound heterozygous animal, the Xpd allelic relationship could shift from Adominant arecessive to Arecessive adominant with respect to different phenotypes in a time - dependent and tissue - specific manner (see below and Table 2).

We are continuing this analysis as the leaders of the imprinting subgroup in GTEx, with particular interest in variable imprinting and molecular mechanisms of allelic silencing.

Our results now show that a particular set of psq allelic combinations gives rise to embryos with terminal defects.

Second, the spatial distribution of allelic frequencies across the hybrid zone revealed a subset of coincident, narrow and stepped clines consistent with reproductive barriers acting to prevent introgression in a fraction of the genome, but also that cline width varied by a factor of 50 with introgressed alleles often reaching the distribution ends of both subspecies [27](Figure S2).

By contrast, the insecticide - resistance markers display heterogeneous allelic distributions with significant differences detected between Central Ugandan (urban) populations relative to Eastern and Southwestern (rural) populations.

The greatest allelic burden was in patients with increased reticulin deposition.

unc - 124 was reported to display hetero - allelic non-complementation with unc - 7; that is, unc - 124 + / + unc - 7 animals were reported to be cs Unc [21, 50].

YY1 binding association with sex - biased transcription revealed through X-linked transcript levels and allelic binding analyses.

In humans, disease susceptibility was mapped to a non-coding 6.1 kb 3» region of CTLA4, the common allelic variation of which was correlated with lower messenger RNA levels of the soluble alternative splice form of CTLA4.

Based on differences in imputed nsSNP allelic frequencies in different genetic backgrounds, likelihood measurements were calculated for European relative to African genetic backgrounds, with distinct patterns emerging as a function of genetic background.

Given that ovulatory dysfunction is a key feature of PCOS, one group investigated a cohort of PCOS patients to determine if there was an association with this polymorphism.68 They reported significant differences in the genotype distribution and allelic frequencies between controls and PCOS patients that supported a correlation with the G / A polymorphism.68 To date, the underlying mechanism has not been established.

Allelic effects at the major gene locus showed nearly to complete dominance, with a recessive, unfavourable allele in both traits.

Four dogs with this allele were DNA sequenced, and none contained the SNP of allelic variant 1.

Reduced allelic diversity and heterozygosity are expected consequences of founder effects, genetic drift, and inbreeding, which are associated with colonization and subsequent small population size (Frankham 1997, 1998).

Allelic dropout becomes more likely with increasing age and associated decreasing quality of DNA samples (e.g., historical or museum specimens — Wandeler et al. 2007).

Socio - economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene - linked polymorphic region

To further determine the specificity of the mediating role of collectivistic cultural values on the association between allelic frequency of the 5 - HTTLPR and mental health disorders, we also conducted regression of mediation on 5 - HTTLPR, individualism — collectivism and two mental health disorders included in the 2008 WHO Mental Health Survey, but not previously associated with the 5 - HTTLPR, namely substance abuse and impulse control.

Analyses were conducted using aggregate published data on allelic frequency of 5 - HTTLPR, cultural values of individualism — collectivism and global prevalence of anxiety and mood disorders, which refers to bipolar disorder, dysthymia and major depressive disorder defined by DSM IV / CIDI criteria in the 2008 World Health Organization (WHO) survey, with nation as the cultural unit of analysis.

Allelic variation in this transporter's gene expression, regulated by a 43 bp indel in the upstream region termed 5 - HTTLPR, was initially associated with anxiety - related traits (23) and has since been investigated in many fields of serotonin - related human genetics (24).

Analyses were conducted using aggregate published data on allelic frequency of 5 - HTTLPR, cultural values of individualism — collectivism and global prevalence of historical and contemporary pathogen prevalence, with nation as the cultural unit of analysis.

The allelic variant, RS3 334, is associated in men, but not women, with a lower bonding quality with the partner (characterized by lower scores on the partner bonding scale and a greater likelihood of reporting martial problems)(Walum et al., 2008).

BACKGROUND: Allelic variation of the monoamine oxidase A (MAOA) gene has been implicated in conduct disorder and antisocial, aggressive behavior in humans when associated with early adverse experiences.

Allelic association with aggression in dogs was observed in the gene coding for the receptor HTR1D [96].