Sentences with phrase «with allogeneic»

Compared with the toxicity that we see with allogeneic donor hematopoietic stem cell therapy, these toxicities are relatively manageable with close monitoring and close supportive care.

Ponatinib Extends Survival Over Transplant in Chronic Phase CML: The results of a new study that included patients from the PACE trial and the European Bone Marrow Transplant registry revealed that treatment with ponatinib yielded better overall survival (OS) compared with allogeneic stem cell transplantation (allo - SCT) in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I mutation.

Retrospective case reports suggest that adults may benefit from consolidation with allogeneic HSCT during their first CR following chemotherapy with one study observing a median overall survival of 38.5 months [5].

The only documented long - term complete remissions reported in multiple myeloma patients have occurred with allogeneic bone marrow transplantation, where a donor's blood stem cells (graft) are transplanted into the patient (host) with multiple myeloma.

The subindication for which now data were available for the first time was allogeneic SCT with related donor in comparison with allogeneic SCT with unrelated donor.

Not exact matches

The company's lead product candidate, dilanubicel (NLA101), is currently being evaluated in two ongoing Phase 2 clinical trials in adult and pediatric patients with hematologic malignancies undergoing an allogeneic transplant and adult patients receiving high dose chemotherapy for Acute Myeloid Leukemia.

Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia.

HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.

In the study, analysis of patient samples demonstrated that high LSC17 scores meant poor outcomes with current standard treatment, even for patients who had undergone allogeneic stem cell transplantation.

Furthermore, 38 percent of allogeneic recipients who participated at the three - year mark had not yet returned to work, and impairment was associated with a tenfold increased odds of not returning to work at three years post-transplant.

«With this research from our longitudinal prospective assessment, we are able to deduce that a significant population of allogeneic BMT survivors will experience cognitive impairment that can and will impact different aspects of their lives moving forward,» Sharafeldin said.

Collaboration with Hematology and Bone Marrow Transplantation Unit research group in molecular diagnostics applied to the management of patients undergoing allogeneic SCT, especially for the detection of minimal residual disease and early relapse.

The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).

Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte - macrophage colony - stimulating factor - secreting breast tumor vaccine: a chemotherapy dose - ranging study of safety and immune activation.

In that program, we focused on treating children with both malignant and genetic conditions with generally allogeneic hematopoietic stem cell transplantation.

These reports suggest that transplantation of MSC could be beneficial in patients with various disorders requiring tissue regeneration, and provide evidence supporting the tolerance of allogeneic MSC by recipients.

Allogeneic Sibling Donor Peripheral Blood Stem Cells Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia in Blast Crisis - Successful Treatment Despite Severe Phase of the Disease

In close collaboration with universities and physicians world - wide, our comprehensive investigational stem cell treatments employ well - targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells for the diseases listed below.

Dr. Goodman is also involved in collaborative efforts with the San Antonio Bone Marrow Transplant Center to study the outcome of allogeneic bone marrow transplants following a relapse from autologous bone marrow transplants.

Bornhäuser M, Kienast J, Trenschel R, et al Reduced - intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open - label randomised phase 3 trial.

Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.

Consistent with these studies, Bartholomew et al 92 showed that allogeneic baboon MSC suppressed the proliferative activity of lymphocytes in vitro and prolonged graft survival.

Koc et al 77 showed no evidence of alloreactive T cells and no incidence of GVHD when allogeneic MSC were infused into patients with Hurler's syndrome or metachromatic leukodystrophy.

Horwitz et al 79 reported that donor MSC contributed to bone remodelling after allogeneic stem cell transplantation (SCT) in 3 children with osteogenesis imperfecta, a rare genetic disorder of type I collagen.

In the future, outpatient blood and bone marrow stem cell transplantation will be offered to a broader group of patients with other blood disorders and for allogeneic transplants (transplant from non-twin donor stem cells).

Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single - Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons.

Hutter G and Thiel E Allogeneic transplantation of CCR5 - deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2.

Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor, according to the results of a study published in Lancet Oncology.

To evaluate the impact of VPA treatment on the preservation of GVL activity, we challenged BALB / c recipients with host - type GFP + acute myeloid leukemia cells (H - 2d) to mimic residual leukemia in patients receiving allogeneic BMT.

VPA was administered i.p. to allogeneic BMT recipients from day 0, with vehicle treatment as control.

A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer.

We found that, in the allogeneic group, IFN - γ +, IL - 17A +, and IFN - γ / IL -17 A double - positive CD4 + T cells derived from spleen (Fig. 2A, 2B) and MLN (Supplemental Fig. 1A, 1B) increased since the early stage after transplantation compared with the syngeneic group, whereas the IFN - γ — and / or IL - 17A — producing CD8 + T cells increased only at the late stage (Supplemental Fig. 1C, 1D).

Because the long - term use of VPA in the clinical setting amassed pharmacokinetics and safety data, it is rational to test VPA in allogeneic BMT patients in combination with standard GVHD prophylaxis or treatment.

Patients receive one of two types of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own stem cells; or allogeneic, in which bone marrow - derived stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.

Low - Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation from an unrelated donor.

Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031.

Allogeneic cell therapies from primary cells for immunotherapy applications are especially challenging because of the vigor with which tissue donors must be screened and qualified to prevent transmission of infectious disease and ensure maintenance of an active donor pool.

This finding supports the hypothesis that parous women with breast cancer fail to harbor a potential source of naturally acquired allogeneic immunity.

Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.

The CD8 + or CD4 + T cell lines were established in vitro by stimulating splenocytes from Gasp + / + and Gasp − / − mice after depleting CD4 + or CD8 + cells, with BALB / c (allogeneic) splenocytes or syngeneic splenocytes in the presence of 2C11 (1 μg / mL).

Should all patients with Hodgkin lymphoma who relapse after autologous SCT be considered for allogeneic SCT?

Macmillan, 2014; Holler, E., et al. «Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: Loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft - versus - host disease.»