Sentences with phrase «with altered cell»

Whole genome sequence data of the mutants with altered cell shape, directed mutants, wild type stocks and isolated helical and rod - shaped «wild type» C. jejuni, identified a number of different mutations in pgp1 and pgp2, which result in a change in helical to rod bacterial cell shape.

Pseudotyping is the process of producing viruses with foreign envelope proteins and is frequently used to generate viruses with altered cell tropism [Cronin et al., 2006].

Not exact matches

Research on a new «gene editing» technology known as CRISPR — which theoretically allows any cell or organism to have its genome altered — is advancing exponentially, with early research ongoing on human embryos created for that purpose.

OAR proponents claim that when the altered donor - cell nucleus with its activated nanog gene is transferred to the enucleated oocyte (egg cell), the presence of nanog will immediately convert the enucleated egg cell to a pluripotent cell, without ever forming a zygote.

God started with a small party in a garden, moved on toward some pow - wows at alters in the desert, then moved into a moveable tabernacle (kind of like an Old Testament RV), then reigned in a temple (especially the God - cave of the Holy of Holies, then disappeared while giving the Jews the silent treatment for some 400 years, then came back to the temple, then traveled the highways and byways with anyone who wanted to join the fun and whooped it up with society's outcasts and wedding attenders, then moved on to some public forums, then into some clandestine home groups and a few jail cells, and eventually made his way into traditional church as we now know it.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Not only did treatment with the AA147 compound activate ATF6 in stem cells, it altered the cells» differentiation path.

Baby Layla's medical team treated her with immune cells altered by one type of the molecular surgical instruments called TALENs.

These differences can affect the biological identity of nanoparticles and thus alter their interaction with the cells.

Vamsi Mootha, a mitochondrial biologist at Massachusetts General Hospital, his graduate student Isha Jain, and their colleagues used a popular DNA - editing tool called CRISPR to knock out about 18,000 different genes in human cells that were altered to have the same problems as people with mitochondrial diseases.

It was unlikely that all 24 genes would be altered simultaneously in any one bacterium, so the cycle was repeated over and over to increase the proportion of cells with mutations in all 24 genes.

To understand that process, the Florida State group engineered a fruit fly to produce a mix of cells, some with normal Lgl and some with the altered version.

He reports that Advanced Cell Technology plans to clone genetically altered animals whose neural tissue would be immunologically compatible with that of humans.

With materials and instructions from the kit, I will introduce CRISPR into the bacteria cells, and use it to rewrite a tiny part of their DNA, creating genetically altered cells that happily thrive on streptomycin.

Chinese scientists have injected a person with CRISPR / Cas9 - edited cells, marking the first time cells altered with the technique have been used in humans.

Some may stem directly from how the altered digestive system works — secreting different levels of hormones, for example — or changes in nerve cells that communicate with the gut.

In that case, six patients suspended antiretroviral therapy for 12 weeks after infusion with zinc finger nuclease — altered CD4 cells.

Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.

Changes to the properties of the lipid bilayer component of the cell membrane can alter the function of proteins embedded in the membrane — proteins that regulate critical functions such as transport of materials in and out of the cell and communication with other cells.

When implanted into mice, the pool of altered cells maintained their gene edits long - term, with no signs of side effects.

They knew that they had found a new type of genetic defect, because the DNA in cancer cells from people with the altered gene was riddled with mutations.

With the help of optogenetics, the research group was able to deactivate specific genetically altered brain cells using light.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Human red blood cells are usually disc - shaped with a central dimple but conditions such as sickle - cell anaemia alter their shape.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem cells (CoSCs) and increased blood levels of a regulatory protein called insulin - like growth factor binding protein 3 (IGFBP3), which is produced in the liver.

Certainly, miRNA levels do not remain altered in the brain cells of mice injected with sperm miRNAs as zygotes.

With a better «nose» for these chemicals, the altered T cells make a beeline for the outer layer of the skin, where they began destroying defective and infected cells, the team reports in the February issue of Nature Immunology.

Now, scientists have discovered a key component of this ancient navigational system in rats: a group of neurons called «speed cells» that alter their firing rates with the pace at which the rodents run.

After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity.

When McKnight was research director at Tularik, which is targeting cancer and other diseases with drugs that alter the cell's production of specific proteins, he spent 30 % to 40 % of his time scraping together dollars.

Its presence influences the behaviour of nanoparticles in the body by altering their chemical properties, destination, and their interactions with other cells.

Researchers suspect the dyes were hydrophobic and altered how the ganglioside interacted with the cell membrane.

«But now we need to find the sweet spot, the Goldilocks spot, where we can alter enough stem cells to allow someone to live with HIV.

The researchers analysed cells from healthy individuals and others with type 2 diabetes and found 25 820 regions of the genome with altered DNA methylation.

Here, six patients suspended combination antiretroviral therapy for 12 weeks after infusion with altered CD4 cells, so scientists could monitor viral load and the power of the altered immune cells to survive and thrive in the presence of active HIV.

Sure enough, plants with mutant versions of these DNA - binding proteins produced root cells with altered levels of Short - root.

The cells will be genetically altered to equip them with a correct copy of the defective gene.

Their answer, garnered through a series of electrophysiology, dendritic spine density and immunohistochemistry experiments with mice that were genetically altered to produce either more new neurons or kill off newborn neurons, supports the second model — some of the cortical neurons transfer their connections from mature granule cells to the new granule cells.

In agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place - modulated granule cells in the dentate gyrus.

But embryonic clones, the source of an endless supply of stem cells imprinted with one's personal DNA, could alter the equation in favor of the patient and augur a paradigm shift in medicine on par with the changes brought about by antibiotics and vaccines.

In combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in these bladder cancer cell lines.

With the aid of centrifuges, Cristoforetti altered the gravitational conditions on the ISS, which enabled the team in the control center to track how the cells reacted.

In the scientific article «Histone mutations separate R loops from genome instability induction» published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA.

By altering the activity of mitochondria — the powerhouses that provide cells with energy — it forces the body to burn fat.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.

But a few weeks later, the virus began to decline, and it dropped to undetectable levels in concert with evidence that the gene therapy had altered his T cells.

And work in fruit flies indicates that they can subtly alter their immune cells to deal with different types of microbes (ScienceNOW, 18 August 2005).

Then the team implanted these altered cells in mice with a form of diabetes to check that they secrete insulin in a way that controls blood sugar levels.