Sentences with phrase «with altered gene»

The evaluation using biostatistical methods revealed a clear connection with an altered gene: ISL1, which is located on chromosome five.

In a race with other scientists, Scottish researchers have bred mice with an altered gene which displays all the key features of cystic fibrosis, such as lung disease and digestive problems.

They knew that they had found a new type of genetic defect, because the DNA in cancer cells from people with the altered gene was riddled with mutations.

Not exact matches

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

Research on a new «gene editing» technology known as CRISPR — which theoretically allows any cell or organism to have its genome altered — is advancing exponentially, with early research ongoing on human embryos created for that purpose.

OAR proponents claim that when the altered donor - cell nucleus with its activated nanog gene is transferred to the enucleated oocyte (egg cell), the presence of nanog will immediately convert the enucleated egg cell to a pluripotent cell, without ever forming a zygote.

Those with naturally goo coordination survive and reproduce at fast rates, altering the frequency of genes in their pool, et, etc, etc..

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n - 6) and (n - 3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

Altered gene imprinting at other times has been associated with developmental disorders and cancer.

The scope of bioethics can expand with biotechnology, including cloning, gene therapy, life extension, human genetic engineering, astroethics and life in space, and manipulation of basic biology through altered DNA, XNA and proteins.

When normal and gene - altered mice got the high - fat diet along with varying levels of doxycycline, to induce GLP1 release, the normal mice grew fat and mice expressing GLP1 showed less weight gain.

He and his colleagues are now investigating how gene profiles are altered and whether these techniques could ease symptoms in people with high blood pressure, inflammatory bowel disease and multiple myeloma, a type of bone marrow cancer.

Next, they grafted this lab - grown gene - altered skin onto mice with intact immune systems.

Gersbach has been working on potential genetic treatments for Duchenne with various gene - altering systems since starting his lab at Duke in 2009.

«My team at Nationwide Children's has worked with commitment and dedication to develop a therapy that may subsequently be shown through future clinical trials to potentially alter the course of this unforgiving condition and provide a therapeutic option for the families and infants with SMA1,» says Jerry Mendell, MD, principal investigator in the Center for Gene Therapy at Nationwide Children's.

When normal and gene - altered mice ate the high - fat diet — along with varying levels of doxycycline to induce GLP1 release — mice expressing GLP1 (left) gained less weight gain while normal mice (right) grew fat.

Dr. Satish Rattan, Professor in the Department of Medicine, Division of Gastroenterology and Hepatology at Jefferson's Sidney Kimmel Medical College, together with Drs. Jagmohan Singh and Ipsita Mohanty, used altered copies of the body's own genetic make - up — small RNA fragments (microRNAs) that regulate the target gene RhoA / ROCK — in order to strengthen or weaken the muscle tone of the sphincter.

Vamsi Mootha, a mitochondrial biologist at Massachusetts General Hospital, his graduate student Isha Jain, and their colleagues used a popular DNA - editing tool called CRISPR to knock out about 18,000 different genes in human cells that were altered to have the same problems as people with mitochondrial diseases.

With hundreds of labs catching CRISPR fever since 2013, most experiments have altered one or two genes at a time, maxing out at five.

It was unlikely that all 24 genes would be altered simultaneously in any one bacterium, so the cycle was repeated over and over to increase the proportion of cells with mutations in all 24 genes.

Individuals with one altered gene had longer telomeres, the caps on the ends of chromosomes that wear away as we get older, and appeared to be protected against diabetes, the researchers report.

When an altered X chromosome is passed down to female offspring, Gantz reasoned, the gene drive should convert the normal X from the other parent into one with a broken yellow gene.

Increasingly vociferous opponents began to challenge the wisdom of altering food crops with pesticide - producing genes in Europe and the United States.

Rather the opposite was true, the altered epigenetic regulation of the gene was responsible for the development of the fatty liver,» added Sophie Saussenthaler, who shared the first authorship with Baumeier.

When produced in excess during times of adversity, these particular miRNAs trigger epigenetic changes, which alter gene activity to cope with these environmental hardships.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.

Gene editing could include altering genes in one person — say to treat leukemia in one patient or make a cosmetic change — but, more controversially, it could also include making changes to the germ line that would then alter the genome for an individual's children, grandchildren and the following generations, with potentially unknown repercussions.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

With their new fruit fly research model, the UNC researchers altered the histone gene so that this particular enzyme could not modify its histone protein target.

Using antibiotics to tamper with this complicated and little - understood population could irrevocably alter the microbial ecology in an individual and accelerate the spread of drug - resistant genes to the public at large.

«What we've determined is that this protein's ability to alter editing of mRNAs is not specific to just a few genes, but instead, its ability to bind to mRNAs is required for proper RNA editing of most mRNAs,» said Michael C. Washburn, a graduate student in the IU College of Arts and Sciences» Department of Biology and first author on the paper with Boyko Kakaradov of the University of California, San Diego.

People with the altered form of the gene have at least a 70 per cent chance of developing colon cancer at some time in their lives, and women with the gene also have at least a 50 per cent chance of developing cancer of the uterus.

Several genes have been associated with depression, especially those genes that alter serotonin signaling.

When implanted into mice, the pool of altered cells maintained their gene edits long - term, with no signs of side effects.

Even though the corn has only four leaves, the way in which its genes are expressed has already been altered through interaction with the velvetleaf planted alongside it, according to plant science professor Sharon Clay.

A major obstacle to applying genetic engineering to benefit humans and the environment is the risk that organisms whose genes have been altered might produce offspring with their natural counterparts, releasing the novel genes into the wild.

Further, investigation of these CpG associations revealed nearby genes whose RNA expression was altered in brain samples with Alzheimer's disease: ANK1, CDH23, DIP2A, RHBDF2, RPL13, RNF34, SERPINF1 and SERPINF2.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

These products are designed to alter the expression of target genes in the body, suppressing expression of genes associated with disease, or restoring expression of genes required for health.

After bombarding hundreds of Caenorhabditis elegans worms with DNA - altering chemicals and screening the results, he found that the deletion of just one gene rendered the worms almost completely resistant to alcohol.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study by researchers at KU Leuven confirms that the gene had an unintended effect on the mice's insulin production, a key variable in diabetes research.

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Its report, Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty and Aligning Research with Public Values, stresses that although gene drive offers great promise for agriculture, conservation, and public health, neither the science nor the current regulatory system is adequate to address the risks and requirements of gene drive — altered organiGene Drives on the Horizon: Advancing Science, Navigating Uncertainty and Aligning Research with Public Values, stresses that although gene drive offers great promise for agriculture, conservation, and public health, neither the science nor the current regulatory system is adequate to address the risks and requirements of gene drive — altered organigene drive offers great promise for agriculture, conservation, and public health, neither the science nor the current regulatory system is adequate to address the risks and requirements of gene drive — altered organigene drive — altered organisms.

That explanation came later, with the burgeoning new field of epigenetics — the study of how the external environment can alter our genes throughout life, and even be passed on to future generations.

Most tests require three groups: controls, genetically altered mice with one copy of the gene of interest, and genetically altered mice with two copies of that gene.

In the Lyme bacteria's genome, the VlsE gene is preceded by «cassettes» which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity.