Sentences with phrase «with altered responses»

Patients with SCI had less excitable nerves with altered responses to electrical stimulation, indicating nerve dysfunction.

Maternal separation is associated with an altered response to stress and epigenetic alterations Rachel Kember, Institute of Psychiatry, King's College London, London, UNITED KINGDOM

Not exact matches

«Chronic stress and overexposure to cortisol — which increases sugars in your bloodstream, alters your immune system responses, suppresses your digestive and reproductive systems, and communicates with that part of your brain that controls mood, motivation and fear — puts you at risk for mental health problems like anxiety and depression, and a whole host of physical health issues,» writes Levy.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

The impassioned responses that followed the post revealed that many women have indeed suffered under the weight of these expectations and struggled at times with guilt whenever pregnancy, sickness, or a major life change alters their appearance.

In contrast, self - paced exercise with a known duration would allow the work rate to be altered in response to a high or subjectively unsustainable RPE.

Depression may affect maternal response via altered sensitivity to their infant's signal.34 Schuetze and Zeskind34 show that perception of infant crying varies with level of maternal depression: as the level of depression increases, infant crying is perceived as less urgent and sick - sounding (i.e., less aversive and less arousing).

Engineered mice with decreased numbers of 5 - HT neurons and rats or piglets with decreased activity secondary to 5 - HT1A autoreceptor stimulation have diminished ventilator responses to carbon dioxide, dysfunctional heat production and heat - loss mechanisms, and altered sleep architecture.43 These studies linked SIDS risk factors with possible pathophysiology.

This one common attribute of defeatism and being practically exhibited by the Npp.The President continue to receive greater publicity even within the opposition media enclave than the flagbearer of the opposition because of the perfect management he enjoys and because he is governing well and introducing people's centered policies.The other advantage the current President has over his main contender is his ability to easily alter his Government's image in a direction which fits in with the mood of the public.This trend was easily seen during his tour across the regions and the responses and addresses delivered by the noble chiefs.

Savino altered her own bill in recent weeks to limit smoking to patients over age 21, specifically in response to concerns from the Senate's Republican conference, which shares control of the chamber with her own five - member Independent Democratic Conference.

One way scientists can understand the genetics of domestication is to look at what parts of the genome are altered in response to living together with humans, Warren added.

The team is already conducting studies with children and adults who have genetic conditions that may alter the normal response to hearing lullabies.

In addition, maternal immunization with Tdap did not substantially alter infant responses to scheduled DTaP.

Protein supplementation alters the physiological responses to a commonly used exercise modality with some differences due to the type of protein utilized,» wrote the researchers.

«This study is the first to offer evidence that intensive and continued meditation practice is associated with enduring improvements in sustained attention and response inhibition, with the potential to alter longitudinal trajectories of cognitive change across a person's life,» said first author Anthony Zanesco, postdoctoral researcher at the University of Miami, who began work on the project before starting his Ph.D. program in psychology at UC Davis.

Researchers have found that a Rocky Mountain mustard plant alters its physical appearance and flowering time in response to different environmental conditions, suggesting some species can quickly shape - shift to cope with climate change without having to migrate or evolve.

Part of the reason for the difference in drug response, say the authors, is that the fusion partner — the non-kinase gene that BRAF or CRAF combines with — alters the tumor's response.

By comparing gene expression in the lungs of ducks infected with either highly or weakly pathogenic avian influenza H5N1 viruses, the team identified genes whose expression patterns were altered in response to avian influenza viruses.

«The studies clearly show that a high - fat diet with or without the genetic loss of ApoE can alter the immune response in mice after heart transplantation,» he continued.

This is the first evidence that the KRAS - variant can predict response to radiation, and that individuals with the KRAS - variant may have an altered immune system.

Likewise, certain brain regions of these optogenetically stimulated, post-stroke mice showed increased levels of proteins associated with heightened ability of nerve cells to alter their structural features in response to experience — for example, practice and learning.

Gene variants associated with GC altered promoters lack immunogenic N - terminal - lacking peptides, enhancing the ability of gastric tumours to evade the native body's immune response.

«With this work,» said Rudd, «we have found a new way to alter the overall immune response.

The final aim of this grant is to examine how the response of microglia to brain damage (i.e., demyelination induced by treatment with cuprizone) is altered when the APOE gene is deleted.

Clonal persistent patients harbored a larger number of residual tumor cells with genotypes and phenotypes that were altered in response to NAC.»

A few interesting articles in early life human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.

They have also begun to develop transgenic mice with mutations in the GABA receptor to verify that alterations in the protein will alter the response to anesthesia or alcohol.

The ageing immune system is less well able to cope with infectious diseases than the youthful immune system probably as a consequence of altered immune response to pathogens.

Then, by running each altered fish through a battery of established behavioral tests — measuring such factors as social interactions, addictive tendencies, sleep and fear response — researchers can see which mutations correspond most strongly with actual behavioral changes.

According to the researcher, this homeostatic state — the tendency to maintain internal stability, due to the mind and body's coordinated responses to any stimulus that disturbs the normal condition — is altered in individuals with addictions and psychiatric disorders such as schizophrenia or anxiety.

There may be a certain level of complexity in elucidating the mechanisms involved in this negative response as we have shown that the response can be easily altered with expression of either ER - α or N1 - ICD, and this suggests that the intrinsic hypoxic response of these cells can be overcome quite simply.

Tumor cells constantly alter their metabolic state in response to oncogenic stimuli, nutrient availability, and interaction with immune cells however the precise regulation that precedes the metabolic alteration is poorly understood.

All of the published medical studies conclude that the combination of mindful breathing in yoga (pranayama) with flow sequences of physical postures (asanas) are what alter the brain's response to stress and therefore create a reduction in pain.

Along with causing insulin resistance, fructose alters the hedonic response to food thereby driving excessive caloric intake, setting up a positive feedback loop for overconsumption.

When the microbiota is depleted, such as after antibiotic use, the immune response is altered, some of which can be restored by proper recolonization with a normal microbiota or specific probiotic strains.

The hormonal dysregulation is part of the body's method for coping with a pathology, and by altering hormone levels you may disrupt the body's response to the disease, allowing it to do more harm.

It is proposed that altered intestinal permeability allows the mucosa to be exposed to bacterial degradation products or other toxins and together with reduced chemotaxic response and altered neutrophil function due to NSAID's, this series of events leads to bacterial invasion of the mucosa which is evident by the techniques of 111Indium leucocyte scans and faecal collections.

Altered levels of adrenocortical hormones have been detected in men with CP / CPPS, indicating that HPA axis impairment and a dysfunctional stress response influence the progression of prostatitis.

Sharing one of my favorite quotes from the late fashion designer Bill Blass, «When in doubt, wear red,» I concurred with Alter's findings that red does indeed have an impact on the response to dates.

In response the Pokémon Company has started cracking down on those with detected altered save data by banning them from online...

The aim of this reform has been to guarantee that, in the quickly - changing digital entertainment industry where new game designs and platforms constantly alter the market environment, we can accurately observe new customer demands and market trends, and apply our long - established technology and knowhow quickly and effectively with a range of targeted responses.

That slogan emerged in the late»90s in response to the special edition of 1977's «Star Wars,» wherein Han Solo's confrontation with Greedo was altered so that the Rodian bounty hunter shot first.

The week closed with a controversy over the fact that Trump altered his major policy address at the last minute in response to a tweet sent by president Nieto.

In particular, the lesson focuses upon the language used by Claudio and Leonato to denounce Hero (with links to the expectations within the social / historical context of the renaissance), the dramatic response to the allegations, and Benedick's altering priorities.

Thankfully the ESC is superb and you can toggle between Auto, Comfort and Sport with the ESC button on the steering wheel (it also alters throttle response and gearbox software).

AMG's engineers have also altered the compression ratio, refined the exhaust port design, changed the way the boost pressure builds and fitted a new dual - mass flywheel that's 0.7 kg lighter than that fitted to the GT S — all with the aim of sharpening throttle response.

These allow you to alter the steering weight and throttle response, but the car feels at its best in the Natural and Dynamic modes, with the eco setting taking a bit too much away from the responses.

There are four drive modes to choose from — altering steering feel, gear shift and engine response — bigger front brakes (+25 mm to 305 mm), 17 - inch alloy wheels with space - saver spare and, of course, Hyundai's acclaimed locally - tuned strut / multi-link suspension which will soon also feature under the next - gen i30.

It gets 4 drive modes — Normal, Eco, All Surface Progress Control (ASPC which works under 30 km / hr) and Dynamic, with each mode altering the throttle response, gearshift and steering weight of the vehicle.

Sport doesn't bring about a discernable difference with the steering wheel or the transmission, for example, but at least it alters throttle response.