Sentences with phrase «with androgen receptors»

Without DHT, no DHT hormone can interact with androgen receptors that can trigger the hair loss.

Not exact matches

The researchers concluded that patients with circulating tumour cells with more N - terminals than C - terminals had the androgen receptor variants.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

For example, levels of estrogen and androgen receptors were upregulated in female - associated placentas while inflammatory markers associated with increased risk of behavioral disorders were upregulated in placentas from both sexes.

On the other hand, we suspect that PCBs could provoke cancer through several mechanisms, which include the interaction with estrogen and androgen hormone receptors, the production of free radicals, or with DNA.

I work in hearing research, and I am now working on genes that are linked to blood (platelet) disorders as well as with mouse models expressing mutant steroid (androgen) receptor genes.

Triple negative breast cancers were recently divided into further subtypes including a subtype with high androgen receptor expression (Lehmann, JCI 2011).

«But what we show is that even triple negative breast cancers with lower androgen receptor expression critically depend on the androgen receptor and may benefit from anti-androgen receptor therapy.

«We're still early in the study of androgen receptor in breast cancer and already scientists are divvying up the disease to say, for example, that only the high AR expressing subtype should be treated with anti-androgen receptor therapies,» Barton says.

To find out, Barton and colleagues treated cell lines with the drug enzalutamide and with shRNAs designed to knock down androgen receptor levels.

«Androgen receptor abnormality may not be associated with primary resistance to taxane chemotherapy.»

At SAGE KE (http://www.sciencemag.org/sciext/drugdisc/#insageke), Raber describes the role of isoform - dependent interactions of apoE with androgens and androgen receptors in the progression of Alzheimer's disease.

Evolution Small peptides known as selective androgen receptor modulators, or SARMs, increase the sensitivity of muscle cells to natural steroid hormones — with fewer undesirable side effects than traditional steroids.

Findings from a small prospective study suggest that androgen receptor V7 (or AR - V7) status does not significantly affect response to taxane chemotherapy in men with metastatic castration - resistant prostate cancer (mCRPC).

AR - V7 is a truncated form of the androgen receptor (AR) that is detected in about a third of patients with castration - resistant prostate cancer.

Impeding the adaptive response of prostate cancer to androgen targeted therapies with relaxin receptor antagonist.

Treatment with an investigational androgen receptor inhibitor significantly delayed the development of metastasis in patients with prostate cancer that had become resistant to standard androgen - deprivation therapy.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

This preclinical work led to the development of a novel anti-androgen ARN - 509, a small - molecule inhibitor discovered in collaboration with UCLA chemist Michael Jung, which targets the increased levels of androgen receptor found in hormone - refractory disease.

(2) Evaluation of AR (Androgen Receptors) Expression in Progressive Metastatic Prostate Cancer Patients Treated with Anti-androgenic Drug: 18F - DHT (18F - 16beta - fluoro - 5alpha - dihydrotestosterone)

«The androgen (male hormone) receptors on the scalp becoming activated,» explains Mark Hammonds, MD, a dermatologist with Scott & White Clinic in Round Rock, Texas.

The supplement increases the number of androgen receptors in the body that can form binding links with free testosterone molecules.

Just as with males, testosterone stimulates androgen receptors in the brain.

While I never recommend the illicit or unsupervised use of pro-hormones (or anything that stimulates androgen receptors), your issues may have very well presented in the same way with or without that history.

Primarily because the chief mechanism of action has to do with the blockade of DHT receptors and not an overall reduction in production of androgens.

With the binding of the synthetic steroids, this will now activate the androgen receptors.

Your doctor informs you that one of them has the AR gene (androgen receptor genes), which has been correlated with an increase in violent behavior.

Ketoconazole attaches to androgen receptors on hair follicles and thus, prevents the receptors from interacting with the hormone dihydrotestosterone (DHT).

For women, your mouth, jawline, neck and chin might clear dramatically since acne correlates with testosterone and DHT in those areas, due to them having a higher androgen receptor density.

Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu.

By combining concentrated water samples with cultures of yeast genetically engineered to have androgen receptors, the scientists were able to measure the amount of anti-androgen activity in each sample.

We explored the neural response to infant cries in fathers of children aged 1 — 2, and its relationship with hormone levels, variation in the androgen receptor (AR) gene, parental attitudes and parental behavior.

«We think some women may get more vulvar dryness with birth control pills because the pills are blocking male sex hormones called androgens, and the vulva has androgen receptors.»