Sentences with phrase «with apolipoprotein»

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype.

The benefit seemed to be particularly pronounced in individuals with the apolipoprotein E-e4 allele, a genetic marker associated with late - onset Alzheimer's, which usually happens after the age of 65, and is the most common type of the disease

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

Depressed neurofilament expression associates with apolipoprotein E3 / E4 genotype in maturing human fetal neurons exposed to HIV - 1.

Not exact matches

HDL with a small proinflammatory protein called apolipoprotein C - III (apoC - III) on its surface may nearly double the risk of heart disease in healthy men and women, according to Frank Sacks, professor of cardiovascular disease prevention at the Harvard School of Public Health and senior author on a paper in the April Journal of the American Heart Association.

After secretion, apolipoprotein E and cholesterol associate with high - density lipoprotein to form a particle that can deliver cholesterol to the liver by receptor - mediated endocytosis.

In «Greater Cognitive Deficits with Sleep - Disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis,» researchers report that study participants carrying the apolipoprotein?

For decades, scientists have known that people with two copies of a gene called apolipoprotein E4 (ApoE4) are much more likely to have Alzheimer's disease at age 65 than the rest of the population.

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

Transplanted hearts lasted in four groups of mice as follows: • 21 days: mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) placed on a high - fat diet • 51 days: healthy mice placed on a high - fat diet leading to hyperlipidemia • 61 days: mice with hyperlipidemia caused by a genetic mutation of ApoE on a lower - fat diet • More than 100 days: healthy mice placed on a lower - fat diet

With the same diet pattern, levels of LDL cholesterol and apolipoprotein B (a secondary end point) increased, with no changes in HDL cholesterol or triglyceride level or blood pressure.&raWith the same diet pattern, levels of LDL cholesterol and apolipoprotein B (a secondary end point) increased, with no changes in HDL cholesterol or triglyceride level or blood pressure.&rawith no changes in HDL cholesterol or triglyceride level or blood pressure.»

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Until recently, only four genes associated with late - onset Alzheimer's have been confirmed, with the gene for apolipoprotein E-e4, APOE - e4, having the largest effect on risk.

Dr. Mahley, along with Gladstone Investigator Yadong Huang, MD, PhD, will use the funding to identify new chemical compounds that can target apolipoprotein E4 (apoE4)-- the strongest genetic risk factor for developing Alzheimer's.

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

Freedman, B. I., et al. «Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.»

The interest intensified several years ago with the surprising discovery that an increased risk of Alzheimer's disease was linked to a natural genetic variant of a key fat - transporter molecule called apolipoprotein E, or apoE.

Apolipoprotein (APOE) genotyping with oversampling of ε4 + individuals will be used to enrich the enrollment sample, such that roughly half of those scanned will be amyloid positive and half will be amyloid negative.

The liver and, to a lesser extent, the intestine produce apolipoprotein C - III (ApoC - III), an 8.8 - kDa glycoprotein associated with TRLs, LDL, and high - density lipoproteins (HDLs)(4).

In a genome - wide analysis of up to 17 503 participants in PROMIS, we identified genetic variants associated with either apolipoprotein (a) isoform size or lipoprotein (a) concentration.

In 60 801 patients with coronary heart disease and 123 504 controls, OR for myocardial infarction was 0 · 96 (0 · 94 - 0 · 98; p < 0 · 0001) per 1 - SD increment in apolipoprotein (a) protein isoform size in serum due to rs2457564, which was directionally concordant with the OR observed in PROMIS for a similar change.

Recent evidence has connected MI risk with coding - sequence mutations at two genes functionally related to APOA5, namely lipoprotein lipase and apolipoprotein C - III (refs 18, 19).

Methods: In this mendelian randomisation study, we measured lipoprotein (a) concentration and determined apolipoprotein (a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the LPA gene) and a serum - based electrophoretic assay in patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMIS).

These ratios of ApoC - III to ApoC - II exceed the normal physiological range of these apolipoproteins present on human VLDL particles, even in patients with hypertriglyceridemia (0.7 to 2)(30).

Lipoprotein (a)- lowering interventions could be preferentially effective in reducing the risk of coronary heart disease in individuals with smaller apolipoprotein (a) isoforms.

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C - III (ApoC - III) levels.

Finally, we compared phenotypic versus genotypic ORs to estimate whether apolipoprotein (a) isoform size, lipoprotein (a) concentration, or both were causally associated with coronary heart disease.

The abnormal composition of apolipoproteins (apo) in the lipoprotein fractions from the patient (P) is compared with the compositions of his mother (M) and a normolipidemic control participant (C).

People with one copy of the variant, called apolipoprotein E-e4 (APOE e4), have a 29 % lifetime risk of developing Alzheimer's disease, while people who don't have it have a 9 % risk.

The investigators also found that eating one or more fish meals a week was linked to less Alzheimer's damage in the brain, but only among people with a gene variant called apolipoprotein E (APOE).

Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia.

Effect of thyroid hormone replacement on lipoprotein (a), lipids, and apolipoproteins in subjects with hypothyroidism.

Contrasting the results of the current study, other studies have shown a reduction in HDL - cholesterol and apolipoprotein A-1 when saturated fat has been replaced with carbs (8, 9).

High - density - lipoprotein (HDL) cholesterol was measured enzymatically after lipoproteins containing apolipoprotein B had been precipitated with heparin — manganese.

Comparison of the effects on lipoproteins and apolipoproteins of a diet high in monounsaturated fatty acids, enriched with avocado, and a high - carbohydrate diet.

Associations of egg and cholesterol intakes with carotid intima - media thickness and risk of incident coronary artery disease according to apolipoprotein E phenotype in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.

Effect of a single oat bran cereal breakfast on serum cholesterol, lipoproteins, and apolipoproteins in patients with hyperlipoproteinemia type IIa.

The apolipoprotein E ε4 allele was associated with Alzheimer's disease in white but not in African - American or Hispanic people

ROC curve analysis: an example showing the relationships among serum lipid and apolipoprotein concentrations in identifying patients with coronary artery disease