Sentences with phrase «with apoptosis»

The Nobiletin in citrus fruit has also been linked with apoptosis, or programmed cell death of cancer cells.

The major mechanism of B cell suppression by MSCs is attributed partly to the physical contact between MSCs and B cells and in part to the soluble factors released by MSCs; this leads to the blocking of B cell proliferation in the G0 / G1 phase of the cell cycle with no apoptosis 28, 29, 30.

However, Mori confirmed in an e-mail that the problematic publication is «Downregulation of citrin, a mitochondrial AGC, is associated with apoptosis of hepatocytes,» which appeared in the 28 December 2007 issue of Biochemical and Biophysical Research Communications.

Not exact matches

As a result, the animals treated with blueberry, spinach, or spirulina were reported to have reduced ischemia / reperfusion - induced apoptosis and cerebral infraction.

This process includes the removal of the milk - producing epithelial cells, whereby the alveolar epithelium undergoes apoptosis and is replaced with adipocytes.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

The nanovesicles fuse with tumor cells, causing them to self - destruct by apoptosis.

In patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.»

If we introduced stem cells with nice, long telomeres in the first place, we could let them wind down and eventually be lost to apoptosis, senescence, or other sources of damage — and just top our tissues up with more stem cells before enough of those cells were lost to begin to impair tissue function.

Chen observed no such growth, however, when she treated retinal explants from normal mice with a compound that blocks apoptosis.

The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia cells to initiate a form of cell suicide known as apoptosis when exposed to agents that induced ER stress.

She earned a Ph.D. from the University of Southern California in which she characterized the mechanisms of sex hormone - induced neuroprotection against apoptosis associated with Alzheimer's disease (AD).

They know from previous studies that apoptosis begins with the activation of what are known as Bax proteins.

The figure shows a confocal microscopy image of a mammalian cell undergoing apoptosis with the mitochondria stained in magenta and the protein Bax in green.

At the IMCB, headed by Professor Chris Tan, we were able to increase our productivity through closer collaborations and interactions with scientists studying apoptosis and cell regulation.

This pathway, the investigators report in Nature Medicine, is very similar to apoptosis (the controlled cell death program thought to exist only in multicellular organisms), but with subtle differences suggesting that it could be specifically targeted for anti-parasitic or - microbial drug development.

The mitochondrial pathway of cell death (apoptosis) starts by permeabilization of the mitochondrial outer membrane which becomes peppered with small holes.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.

When the team injected the shielded mice with a chemical that blocks cell - to - cell communication before irradiating them, they detected no DNA breaks and the amount of apoptosis decreased more than threefold.

T. cruzi is already known to disguise its cell surface with human proteins and sugars: apoptosis would be yet another weapon in the arsenal that helps it evade the immune system.

This suggests that long - term exposure to Mcf1 causes hemocytes to ultimately undergo apoptosis consistent with previous studies using Manduca caterpillars.

Mcf1 treated caterpillars show rapid loss of body turgor (the «floppy» phenotype) within 12 hours, associated with massive apoptosis of the midgut epithelium.

Mammalian cells treated with Mcf1 also display key features of apoptosis which is putatively mediated by a BH3 - like domain and involves the mitochondrial pathway [24], [25].

In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodes.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).

The in vitro boosted effector cells were washed once with HBSS and then resuspended in CRPMI and used as effector cells in the cytotoxicity and apoptosis assays (below).

In particular, alterations in genes associated with response to stress, apoptosis, ion channel activity, and neuronal and synaptic modeling were observed.

IG20 (MADD splice variant - 5), a proapoptotic protein, interacts with DR4 / DR5 and enhances TRAIL - induced apoptosis by increasing recruitment of FADD and caspase - 8 to the DISC.

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3 ′ Uridylated Intermediates Degraded by DIS3L2.

In addition, consistent with past studies, AAV2 - infected cancer cells produced more Ki - 67, an immunity system activating protein and c - Myc, a protein that helps both to increase cell growth and induce apoptosis.

Apoptosis of the corneal cells was then measured at various time - points with the TACS Annexin V - FITC apoptosis detection system (R&D Systems, MinneapoApoptosis of the corneal cells was then measured at various time - points with the TACS Annexin V - FITC apoptosis detection system (R&D Systems, Minneapoapoptosis detection system (R&D Systems, Minneapolis, MN).

Interestingly, p21 - null lymphomas exhibited a high level of apoptosis with tangible apoptotic bodies, often surrounded by a narrow halo indicative of phagocytosis (Fig. 4B) ⇓.

Human Cytomegalovirus Interacts with Toll - like Receptor 2 and CD14 on Syncytiotrophoblasts to Stimulate Expression of TNFα mRNA and Apoptosis.

Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl - 2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells.

SZ - 685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt / FOXO pathway.

We conclude that thymic lymphomas in p21 - null mice have a significantly higher level of apoptosis compared with that in wild - type mice.

Homocysteine - Induced Apoptosis in Endothelial Cells Coincides With Nuclear NOX2 and Peri-nuclear NOX4 Activity.

p21 - deficient lymphomas (n = 2) presented a high level of apoptosis, compared with wild - type lymphomas (n = 3).

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Inhibition of c - Abl with STI571 attenuates stress - activated protein kinase activation and apoptosis in the cellular response to 1 - β - d - arabinofuranosylcytosine.

Morphologic examination of the Hoechst - stained cell preparations at 16 hours after treatment with 20 nmol / L rapamycin showed morphologic evidence of apoptosis, such as nuclear condensation and fragmentation in ALCL cells (A, bottom right).

In this case, the trigger is a drug that interacts with the protein produced by the «suicide gene,» which metabolizes it into a form deadly to the cell, causing it to commit programmed cell death (apoptosis).

Apoptosis following inhibition of mTOR expression or function was associated with down - regulation of antiapoptotic proteins, including c - FLIP, MCL - 1, and BCL - 2.

We also show that rapamycin and total mTOR silencing induces cell cycle arrest and apoptosis interfering with proliferation and survival pathways in ALK + ALCL.

I saw a Horizon programme on apoptosis with Gerard Evan and Martin Raff.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.