Sentences with phrase «with apoptotic»

In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated with apoptotic cell death.

Not exact matches

She recently co-authored a paper with Kantorow and research colleagues titled «Integrin αVβ5 - mediated removal of apoptotic cell debris by the eye lens and its inhibition by UV - light exposure,» published in the Journal of Biological Chemistry.

The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).

Moreover, the allospecific apoptotic activity of the putative DN T cells was abolished in two separate experiments using in vitro treatment with anti-Thy 1.2 antibody plus complement, which removed > 97 % of the Thy 1 + cells, as determined by flow cytometry.

Interestingly, p21 - null lymphomas exhibited a high level of apoptosis with tangible apoptotic bodies, often surrounded by a narrow halo indicative of phagocytosis (Fig. 4B) ⇓.

Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch.

Treatment of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.

Lin chart illustrates the correlation between Cyclin D1 IOD in Grade III with percentage of apoptotic phase.

To study the underlying apoptotic mechanisms, expression of apoptosis regulators was assessed after treatment with rapamycin or specific mTOR siRNA.

Compared with the untreated group and the groups treated with single agents, the number of apoptotic tumor cells was increased following combined treatment (Figure 4D).

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer.

The extrinsic apoptotic pathway is activated by external signals through transmembrane tumour necrosis factor receptors (TNFRs) whose intracellular death domain interacts with downstream adaptors.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

In fact, short term treatment of patients with amiodarone leads to a significant decrease in the patient's serum TNFα concentrations while paradoxically the amiodarone toxicity is exerted through TNF - mediated apoptotic pathways [41].

These observations demonstrate that with a pregnancy preexisting premalignant mammary cells overcome both the apoptotic response to an oncoprotein and the robust cell death at involution, which normally clears the large mass of cells gained during pregnancy / lactation.

We were among the first to show that apoptotic bodies could enhance cross priming in patients with spontaneous tumors.