In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated
with apoptotic cell death.
Not exact matches
She recently co-authored a paper
with Kantorow and research colleagues titled «Integrin αVβ5 - mediated removal of
apoptotic cell debris by the eye lens and its inhibition by UV - light exposure,» published in the Journal of Biological Chemistry.
The present demonstration of T
cell - mediated apoptosis of allogeneic corneal
cells from CD4 KO mice is consistent
with previous findings, which noted the presence of
apoptotic keratocytes and corneal endothelial
cells in rejected corneal allografts in humans and rats respectively (5, 32).
Moreover, the allospecific
apoptotic activity of the putative DN T
cells was abolished in two separate experiments using in vitro treatment
with anti-Thy 1.2 antibody plus complement, which removed > 97 % of the Thy 1 +
cells, as determined by flow cytometry.
Preferential induction of
apoptotic cell death in melanoma
cells as compared
with normal keratinocytes using a non-thermal plasma torch.
Treatment of lung cancer
cell lines
with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by
apoptotic cell death.
Compared
with the untreated group and the groups treated
with single agents, the number of
apoptotic tumor
cells was increased following combined treatment (Figure 4D).
In human gastric tissue, however, gastric epithelial
cell proliferation is significantly higher but
apoptotic indices are lower among persons colonized
with cag + compared to cag - strains or uninfected persons leading us to postulate that reduced rates of
cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized
cells, which could predispose towards cancer.
These observations demonstrate that
with a pregnancy preexisting premalignant mammary
cells overcome both the
apoptotic response to an oncoprotein and the robust
cell death at involution, which normally clears the large mass of
cells gained during pregnancy / lactation.