Sentences with phrase «with autologous»

In this study, we clinically tested a therapeutic platform that we have previously described in preclinical studies [12] in which B cells from NHL dogs are expanded in vitro using CD40L transfected K562 cells (KtCD40L) and then loaded with autologous tumor RNA to generate a cell - based vaccine.

Tamura, Y., et al., 1997, Immunotherapy of tumors with autologous tumor - derived heat shock protein preparations, Science, 278:117 - 120.

The strongest challenge to this approach, granting the periodic replenishment of somatic stem - cell pools with autologous but OncoSENS - ready stem cells, has been the possible existence of functions of TERT (telomerase reverse transcriptase — the catalytic subunit of telomerase), other than the lengthening of telomeres itself.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.

Therapy With Autologous Adipose - Derived Regenerative Cells for the Care of Chronic Ulcer of Lower Limbs in Patients with Peripheral Arterial Disease (March 20, 2013) in Journal of Surgical Research.

In another study by Tan et al 212, 104 patients were inoculated with autologous BM - MSC (1 - 2 x106 / kg) at kidney reperfusion and two weeks later.

Pramod Srivastava, Giorgio Parmiani, and colleagues report that immunization with autologous tumor - derived gp96 - peptide complexes elicits tumor regression in stage IV melanoma patients, without any immunization - related adverse events.

Tan J, Wu W, Xu X, Liao L, Zheng F, Messinger S, Sun X, Chen J, Yang S, Cai J, Gao X, Pileggi A, Ricordi C. Induction therapy with autologous mesenchymal stem cells in living - related kidney transplants: a randomized controlled trial.

Conditional survival and excess mortality after high - dose therapy with autologous stem cell transplantation for adult refractory or relapsed Hodgkin lymphoma in Norway.

A national study on conditional survival, excess mortality and second cancer after high dose therapy with autologous stem cell transplantation for non-Hodgkin lymphoma.

Pattern of employment and associated factors in long - term lymphoma survivors 10 years after high - dose chemotherapy with autologous stem cell transplantation.

His group was the first to publish findings of dramatic molecular remissions in patients with chemorefractory acute lymphoblastic leukemia following treatment with autologous CD19 - targeted T cells.

Rodrigo Gouvea Rosique, MD, PhD, of Master Hospital of Plastic Surgery in Goiânia, Goiás, Brazil, and colleagues outline their safe and effective technique of «gluteoplasty with autologous fat tissue» for buttocks augmentation.

Not exact matches

«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for Human Development, Stem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explains.

«If we win, the entire regulatory structure for autologous cell processing, with or without culture, will be rewritten such that any physician using good practices and treating patients responsibly can use stem cells as part of his or her medical practice,» he says.

Reconstruction operations with implants involves the use of prosthetic breasts made of saline or silicone gel, while reconstruction using the patient's own abdominal tissue, known as autologous transfer, requires additional incisions, harvesting of tissue and transplantation of that to the breast.

For this analysis, 605 patients with newly diagnosed multiple myeloma and treated with continuous lenalidomide (brand name Revlimid) following autologous stem cell transplant were compared to 604 patients who were treated with placebo or no maintenance.

«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.

HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

The investigational treatment was combined with chemotherapy and an autologous stem cell transplant — a new strategy designed to target and kill the cells that give rise to myeloma cells.

(Right) Autologous tier 2 serum NAb titers (IC50) in 50 animals immunized with various uncleaved gp140 proteins, compared to titers in the 30 rabbits given the BG505 or B41 SOSIP.664 trimers described here (see legend of Fig. 2 in the full article for details; P < 0.0001, two - tailed Mann - Whitney test).

Dr. Henry presented «Final Results for THE ATHENA TRIALS: Autologous Adipose Derived Regenerative Cells (ADRCs) for Refractory Chronic Myocardial Ischemia with Left Ventricular (LV) Dysfunction» on Thursday, May 5, 2016 at 11:00 a.m. ET.

Autologous tier 2 NAb responses in animals immunized with native - like (SOSIP.664) trimers or non-native uncleaved gp140s.

The therapy is approved by the U.S. Food and Drug Administration for relapsed or treatment - resistant Hodgkin lymphoma, and it is commonly prescribed to patients whose disease has progressed after autologous stem cell transplant, a procedure that replenishes the bone marrow with the patient's own healthy stem cells after therapy.

Patients treated with processed autologous adipose - derived regenerative cells (ADRCs) injected into the heart muscle demonstrated symptomatic improvement and a trend towards lower rates of heart failure hospitalizations and angina, despite no improvement in left ventricle ejection fraction (LVEF) or ventricular volumes.

The treatment in the current study, called autologous hematopoietic stem cell transplantation (AHSCT), was given to patients with advanced forms of the disease that had failed to respond to other medications.

«Autologous stem cell transplant should be standard care for HIV - associated lymphoma: Multicenter, Phase II trial suggests autologous transplant should be standard of care for HIV patients with relapsed / treatment - resistant lymphoAutologous stem cell transplant should be standard care for HIV - associated lymphoma: Multicenter, Phase II trial suggests autologous transplant should be standard of care for HIV patients with relapsed / treatment - resistant lymphoautologous transplant should be standard of care for HIV patients with relapsed / treatment - resistant lymphoma.»

However, these problems associated with histocompatibility may be solved using autologous donor adult stem cells, therapeutic cloning, stem cell banks or more recently by reprogramming of somatic cells with defined factors (e.g. induced pluripotent stem cells).

To infect the mice with HIV - 1, 105 autologous CD4 + T cells previously infected with X4 HIV - 1 strain Bk132 were injected into the tail vein of each mouse.

Based on our data, autologous stem cell transplant should be considered the standard of care for patients with HIV - related lymphomas for the same indications and under the same circumstances that we would use it in patients without HIV infection.»

Along with the investigational monoclonal antibody, study participants underwent multi-drug chemotherapy, surgery, radiation and autologous hematopoietic stem cell transplantation.

In addition, transgenic autologous hematopoietic stem cells can be successfully transplanted in HIV - infected individuals [18] and several phase I adoptive transfer trials of CD4 + T cells treated with R5 - ZFNs in HIV infected individuals are currently underway.

On day 28 post-engraftment, mice were intravenously injected with 105 autologous CD4 + T cells that were previously infected with the highly cytopathic X4 HIV - 1 strain Bk132 or a mock control.

A similar pattern of neutralization activity for the GL VHH was seen, with GL B9 and A14 neutralizing R2 only and GL B21 neutralizing both autologous viruses (Fig. 7C, D) although in all cases the neutralization by the GL VHH was less potent than by the mature VHH.

Other researchers at Joslin are conducting large scale genetic screening for novel therapeutic targets to control autoimmunity, which will complement the effort of BAIRT to extend autologous beta cell replacement to patients with type 1 diabetes.

Mukherji B, Chakraborty NG, Yamasaki S, Okino T, Yamase H, Sporn JR, Kurtzman SK, Ergin MT, Ozols J, Meehan J, Mauri F. Induction of antigen - specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide - pulsed autologous antigen presenting cells.

While undergoing treatment in what was described as a clinical trial, three elderly patients with macular degeneration were blinded after being administered a treatment based on autologous adipose tissue.

Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

We published the first experience with double autologous peripheral blood stem cell transplant for high - risk neuroblastoma.

In close collaboration with universities and physicians world - wide, our comprehensive investigational stem cell treatments employ well - targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells for the diseases listed below.

Dr. Goodman is also involved in collaborative efforts with the San Antonio Bone Marrow Transplant Center to study the outcome of allogeneic bone marrow transplants following a relapse from autologous bone marrow transplants.

After 6 months, 4 of 53 patients in the autologous MSC plus standard - dose CNI group and 4 of 52 patients in the low - dose group had steroid responsive biopsy - proven rejections compared with 11 of 51 controls who had steroid - resistant rejections.

Effect of Preoperative Autologous Blood Donation Coupled With Fluid Resuscitation on Transfusion Requirements Following Orthopedic Surgery

In 2016, the Food and Drug Administration (FDA), the branch of government charged with regulating cellular therapies, took action to address these issues, proposing revised guidelines that could change how stem cells, especially autologous stem cells, are regulated.

AST - VAC1 (antigen - presenting autologous dendritic cells) is an autologous cancer immunotherapy with promising efficacy and safety data from a Phase 2 study in Acute Myeloid Leukemia (AML).

Swine Model of Thrombotic Caval Occlusion Created by Autologous Thrombus Injection with Assistance of Intra-caval Net Knitting.

Meeting scalability challenges for autologous cell - based manufacturing with automated closed - system solutions

Biological markers of Mesenchymal Stromal Cells as Predictors of response to Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study.

37 patients received autologous MSCs via intrathecal injection, rather than direct spinal cord injection, in two monthly doses, and were then followed up at 6 months with responders (ALS - R) and non-responders (ALS - N) identified using the revised ALS functional rating scale (ALSFRS - R).