Sentences with phrase «with brain metastases»

For patients with non-small cell lung cancer with brain metastases, treatment with whole brain radiotherapy may not offer much benefit.

Early results from an ongoing trial suggest that pembrolizumab has promising activity in untreated melanoma patients with brain metastases.

Subgroup analyses showed benefit with the combination in all groups, with the exception of those with brain metastases at baseline, though this included a total of only 12 patients.

[22] Formal data on other compounds in development, including ASP8273, PF - 7775, EGF816, and HM61713, in patients with brain metastases are still awaited.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

Safety and clinical activity of ipilimumab in melanoma patients with brain metastases: retrospective analysis of data from a phase 2 trial.

[32] In patients with brain metastases in the AZD3759 phase I clinical trial, 63 % (12 of 19 patients) achieved an intracranial response and 50 % (10 of 20 patients) had an extracranial response.

While therapies that target HER2 and HER3 are clinically available, clinical trials often exclude patients with brain metastases.

Whole brain radiotherapy (WBRT) significantly improves tumor control in the brain after SRS, yet because of its association with cognitive decline, its role in the treatment of patients with brain metastases remains controversial.

«Rare mutation may extend survival in lung cancer patients with brain metastases.»

The study used samples from lung cancer patients with brain metastases.

Many lung cancer trials have traditionally excluded patients with brain metastases at baseline, expecting that the presence of metastases would create negative results that could in turn create the appearance of drug failure.

Not exact matches

This means that when we rely on analysis of a primary tumour we may miss mutations in the brain metastases that we could potentially target and treat effectively with drugs.»

Research from McMaster University has identified new regulators of brain metastases in patients with lung cancer.

«If you look at a set of lung cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hospital.

Since whole - brain radiation is associated with significant cognitive effects and the use of additional radiation therapy for progression is common in this population, the Yale researchers suspect that patients with the ALK mutation would benefit from radiation focused on individual metastases.

A pre-surgery tumor size of greater than three centimeters was associated with worse LC, but local recurrence was not significantly affected by the number of brain metastases or the patients» histology or graded prognosis assessments.

Approximately 30 percent of patients with cancer develop brain metastases, and the incidence of these lesions is rising.

Paul D. Brown, M.D., of Mayo Clinic, Rochester, Minn., and colleagues conducted a study in which 213 patients with 1 to 3 brain metastases were randomly assigned to receive SRS alone (n = 111) or SRS plus WBRT (n = 102).

In the case of breast cancer driven by overexpression of the HER2 gene, up to 50 percent of patients treated with targeted therapies eventually develop brain metastases, which are inevitably fatal.

While neither a drug that targets HER3 nor one that interferes with the interaction between HER2 and HER3 were able to slow the growth of brain metastases, combined treatment with both an anti-HER2 and an anti-HER3 drug significantly slowed tumor growth.

«Stem cell - based therapy for targeting skin - to - brain cancer: Stem cells loaded with oncolytic viruses show promising results in preclinical models for targeting skin cancer metastases in the brain.»

A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320.

Subjects with known brain metastases.

Novel strategies that are effective in treating brain metastases in patients with lung cancer are needed.

[38] A retrospective study of 90 patients with ALK - rearranged NSCLC metastatic to the brain found that OS after the development of brain metastases was still prolonged at approximately 4 years (49.5 months), with patients frequently having multiple opportunities for salvage SRS at recurrence; 45 % of patients on follow - up had progressive brain metastases at death.

[38] The median time to CNS progression was 7 months in patients with previously untreated brain metastases.

Undergoing immunotherapy within a month of stereotactic radiosurgery resulted in an improved response to treatment for patients with melanoma brain metastases.

It has been suggested to replace the diagnosis - specific graded prognostic assessment (DS - GPA, based on performance status and number of brain metastases) for patients with primary malignant melanoma with the new Melanoma - molGPA.