Sentences with phrase «with brain receptors»

Huffman hoped to understand how THC and related compounds interact with brain receptors and perhaps find treatments for nausea and glaucoma.

Not exact matches

Our brains are loaded with receptors for capsaicin, and we respond to it by releasing endorphins, natural compounds that have a calming effect.

Not to mention that our brains have cannabinoid receptors that we are born with and they become active and our bodies release natural pain relief during natural childbirth, and natural childbirth only.

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

One of your biggest discoveries was how addiction affects the D2 receptor, the protein that determines how sensitive individuals are to the release of the neurotransmitter dopamine, a chemical in the brain associated with feelings of reward and pleasure.

«These effects were reduced, however, in terms of both intensity and duration, if the mice had been treated with a kappa - opioid receptor antagonist, a drug that blocks the activity of one of the brain's own opioid systems.»

And so we found a variant in one of the GABA receptors [that] is associated with alcoholism, and this fits in with some of the brain wave pattern activity that it looks like alcoholism [and] is linked to disinhibition, so [it's] a problem with the inhibition of brain waves that people should generally have.

They found that elevated anxious temperament is associated with decreased messenger RNA expression of two neuropeptide Y receptors, Y1R and Y5R, in the central nucleus of the amygdala, a region of the brain that plays an important role in regulating fear and anxiety.

The neurons send their signals to the brain's olfactory bulb, where each of thousands of little clusters of neurons called glomeruli receives input from olfactory neurons with just one receptor type.

A new report in the current issue of Biological Psychiatry by researchers at the University of Wisconsin at Madison suggests that deficits in one of the brain's off switches for anxiety, neuropeptide Y receptors, are decreased in association with anxious temperament.

Conditions that cause the brain's receptors to stop functioning properly are often mistaken for schizophrenia or bipolar disorder because these diseases are associated with a decrease in activity of the NMDA receptors, which control how someone thinks, makes decisions, and perceives the world around them.

Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain.

This pruning changes the relative density of receptors in the circuit linking the area of the brain involved with processing rewards (the basal ganglia) and the area of the brain implicated in inhibition and control (the prefrontal cortex).

To find evidence for the phenomenon, her team began looking for MHCI receptors in the brain — literally, molecules that would connect with MHCI to help get the message through.

Despite all of these negative effects they have very little benefit in improving psychosis in people with dementia Pimavanserin works differently to other antipsychotics, by blocking a very specific nerve receptor (THT2A) in the brain.

In a final experiment, the group gave the animals a compound that prevented LPA from binding to its receptor on mouse brain cells, right before they were injected with hydrocephalus - inducing LPA.

When THC strikes specific cannabinoid receptors, it triggers domino chains of interacting molecules in neurons that culminate in both unusually elevated and abnormally low levels of various neurotransmitters (the molecules that brain cells use to communicate with one another).

The participants were injected with a radioactive compound which binds to their brain's opioid receptors.

Now researchers report that they have sorted out how the drug toys with nicotine receptors in the brain.

«Brain genes related to innovation revealed in birds: Glutamate brain receptors, linked with human intelligence, are also associated with problem - solving skills in wild birds.&rBrain genes related to innovation revealed in birds: Glutamate brain receptors, linked with human intelligence, are also associated with problem - solving skills in wild birds.&rbrain receptors, linked with human intelligence, are also associated with problem - solving skills in wild birds.»

This illustration shows how the rabies virus inhibits nicotinic receptors in the brain, which interferes with communication and induces frenzied behavior.

Indeed, by examining brain tissue and slices from the cocaine - addicted rats at various stages of withdrawal and craving, Wolf and her colleagues discovered that the incubation period and the subsequent spike in craving appeared to correlate with the appearance of atypical AMPA receptors on the surface of neurons in the NAc, which could help explain cocaine craving.

Maged Harraz, Ph.D., a research associate and the first author of the newly published research paper, says the researchers already knew that ketamine interacts with excitatory NMDA receptors on nerve cells in the brain to block their activity.

These compounds block the neurotransmitter acetylcholine from interacting with its receptors in the brain.

Autism - linked protein SHANK3 (red) and pain receptor TRPV1 (green) interact with one another in sensory neurons outside of the brain.

By pairing a receptor that targets neurons with a molecule that degrades the main component of Alzheimer's plaques, the biologists were able to substantially dissolve these plaques in mice brains and human brain tissue, offering a potential mechanism for treating the debilitating disease, as well as other conditions that involve either the brain or the eyes.

Anandamide is among a class of naturally occurring chemicals in the body known as endocannabinoids that attach to the same brain cell receptors as does marijuana's active ingredient, THC, with similar outcomes.

«The brain along with the reproductive system and every other cell in your body is exquisitely sensitive to exceedingly small changes in estrogen and other sex hormones, and the fact that the environment is full of chemicals that can activate estrogen receptors means this phenomenally sensitive system is being perturbed constantly by environmental factors.»

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.

At the same time, the obese girls sipping milk shakes showed decreased activation in the striatum, a region near the center of the brain that is studded with dopamine receptors and known to respond to stimuli associated with rewards.

The brain can't actually feel pain despite its billions of neurons, Godwin said, but the pain associated with brain freeze is sensed by receptors in the outer covering of the brain called the meninges, where the two arteries meet.

Biochemical tests of the adult animals showed that THC - doused brains had the same number of receptors that responded to THC as unexposed rat brains, but more receptors for heroin and more of a compound associated with reward behavior in their neurons, the team reports online 5 July in Neuropsychopharmacology.

Many researchers are also hopeful about clinical trials under way with drugs that block certain receptors for glutamate, the main neurotransmitter in the brain that excites neural activity.

This unexpected result fits with previous work showing that E and Z males have different connections between the neurons harboring pheromone receptors and the brain.

In 2010 biologist Valerie Hu of the George Washington University Medical Center and her colleagues found that brains of people with autism have low levels of a protein produced by a gene called retinoic acid — related orphan receptor - alpha (RORA).

The participants were injected with radioactive compounds that bind to their brain's opioid and dopamine receptors.

The group employed various viral tracing methods — infecting receptor - expressing neurons with a virus strain and watching them spread as they label infected cells with a fluorescent protein — to visualize the neural circuit downstream of the ESP1 receptor, as well as providing an image of nerve fibers belonging to specific neurons in the brain and synapses relaying impulses from neuron to neuron, to map the anatomical foundation that conveys ESP1 signals in the brain.

Think of brain cells as rooms with locks called receptors on their surfaces and a hypocretin as a key that is also a stimulant.

In a final experiment, when the researchers gave the bees a drug that disrupted receptors for dopamine, a neurotransmitter linked with motivation and reward, the bias disappeared, echoing the way this brain chemical works in mammals.

Mansuy says the behavioral changes were associated with an increased level of the glucocorticoid receptor in the hippocampus — the part of the brain that contributes to stress responses.

The scientists used imaging techniques to visualize the activity in certain areas of the flies» brains while these were stimulated with different odours, and they were able to localize and identify the receptor for citrus.

Given via injection or nasal spray, naloxone binds powerfully with opiate receptors in the brain, repelling the drugs the user has taken and sending him or her into an instant and painful withdrawal.

Receptors facilitate chemical and electrical signals between neurons in the brain, allowing those neurons to communicate with each other.

Key to the researchers» efforts to track oxytocin at work in individual brain cells was use of an antibody developed at NYU Langone that specifically binds to oxytocin - receptor proteins on each neuron, allowing the cells to be seen with a microscope.

Researchers with Oregon Health & Science University's Vollum Institute have given science a new and unprecedented 3 - D view of one of the most important receptors in the brain — a receptor that allows us to learn and remember, and whose dysfunction is involved in a wide range of neurological diseases and conditions, including Alzheimer's, Parkinson's, schizophrenia and depression.

Numerous experiments with genetically altered mice and rats have shown that when natural brain compounds, called endocannabinoids, are missing or their receptors are blocked, the animals are more susceptible to pain, can not control their appetites, have trouble handling anxiety and are less able to cope with stress.

He examines several well - studied receptors — the bacterial aspartate receptor (Tar), human epidermal growth factor receptor (EGFR), and human brain - derived neurotrophin receptor (BDNFR)-- and comes to a conclusion that they all have similar chemical structures with or without their corresponding ligands.

Four cloned cDNAs encoding 900 - amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library.

Researchers have long suspected that a brain receptor called TrkB was involved with the growth of spines when we learn, but the new study confirms that the receptor is indeed crucial and delves further into how it works.