Not exact matches
Protein immunoblot and histochemical analysis
with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH -(reduced form of nicotinamide adenine dinucleotide phosphate), Ca2 + /
calmodulin - dependent type I NO synthase of about 150 kilodaltons.
They found that, as
with calcium channels, increasing calcium concentrations caused
calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.
In so doing, «it can be seen that calcium - free
calmodulin is in no way dormant, but instead markedly boosts the opening of calcium and sodium channels to begin
with,» Yue says.
In the course of screening over 180 mutant mouse strains
with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice
with heterozygous knockout of the alpha - isoform of calcium /
calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent
with bipolar disorder.
Among the most interesting ones identified were those associated
with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding,
calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.
A pollen - specific
calmodulin - binding protein, NPG1, interacts
with putative pectate lyases.
In his recent work, Mesubi found that two proteins (
calmodulin kinase II and O - GlcNAc) are critical to the increased risk for atrial fibrillation for patients
with diabetes mellitus.