Here, we demonstrate that MISC is feasible at an X-ray free electron laser by studying the reaction of M. tuberculosisß - lactamase microcrystals
with ceftriaxone antibiotic solution.
Treatment of C3H mice
with ceftriaxone is a useful model for investigation of post-treatment persistence of non-cultivable B. burgdorferi.
Treatment
with ceftriaxone, and high or low doses of tigecycline resulted in the same outcome: persistence of non-cultivable B. burgdorferi in tissues of treated mice at 90 days after completion of treatment [14].
Not exact matches
The results suggest that dual therapy
with azithromycin and
ceftriaxone, which has been recommended by WHO and many countries to treat gonorrhea, may not prove effective in China.
Neisseria gonorrhoeae (N. gonorrhoeae) strains resistant to azithromycin and / or
with decreased susceptibility to
ceftriaxone are common in China, according to a prevalence study published this week in PLOS Medicine.
Forty - six countries have reported gonorrhea strains
with decreased susceptibility to
ceftriaxone, and 10 have reported patients for whom none of the usual antibiotics were effective, Wi says.
Patients, enrolled in an NIH funded study, met the following criteria [17]: (1) current positive IgG Western blot using CDC surveillance criteria assessed using a single reference laboratory (University Hospital of Stony Brook); (2) treatment for Lyme disease
with at least 3 weeks of intravenous
ceftriaxone or cefotaxime that was completed at least 4 months before study entry; and (3) objective evidence of memory impairment as documented by the Wechsler Memory Scale - III compared to age -, sex - and education - adjusted population norms.
Collectively, these studies by multiple research groups in multiple mammalian species following treatment
with an array of antimicrobial drugs, including doxycycline, ampicillin, amoxicillin,
ceftriaxone, and tigecycline, have documented a similar outcome: persistence of non-cultivable B. burgdorferi following antibiotic treatment.
Lyme disease patients
with heart or nervous system problems may be given a two - to four - week course of IV antibiotics, such as
ceftriaxone or penicillin.
This cluster of drug - resistant cases was identified in Honolulu in April and May of this year,
with five infections showing «dramatic» resistance to azithromycin, as well as reduced vulnerability to
ceftriaxone.
While azithromycin interferes
with the bacteria's ability to make proteins, and
ceftriaxone causes the cell wall to fall apart, this new drug acts on a crucial protein involved in bacterial DNA replication.