Sentences with phrase «with cell cycle»

High Expression of FAM83B Predicts Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma and Correlates with Cell Cycle and Cell Proliferation Chao - qin Shen, Ting - Ting Yan, Wei Liu, Xiao - qiang Zhu, Xiang - long Tian, Xue - liang Fu, Rong Hua, Jun - feng Zhang, Yan - miao Huo, De-jun Liu, Jian - yu Yang, Yong - Wei Sun, Jing - Yuan Fang, Hao - Yan Chen, Jie Hong Journal of Cancer 2017; 8:3154 - 3165

They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.

«We knew that metabolism often oscillated in synchrony with the cell cycle.

These molecules showed clear oscillatory patterns, rhythms that usually beat in synchrony with the cell cycle.

Alex Dammermann and his team from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna, together with his collaborators from the Institute of Molecular Pathology (IMP), have been investigating how the duplication of one key component of the cell division machinery, named centrioles, is coordinated with the cell cycle — the series of events that lead to a cell's division.

The roots of Arabidopsis thaliana with their cell cycles visualized.

Not exact matches

It matches up with the observed entire life cycle and doubling rate (about every 8 hours) of the single celled organism.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

They found that epigallocatechin gallate, or EGCg, which is found in all tea, inhibits the activity of tNOX, an overactive enzyme that interferes with a cell's divide - and - rest cycle, and can facilitate uninterrupted growth of cancerous cells when combined with other factors.

He spent his last year as a Lisbon student studying cell - cycle regulation in yeast at the University of Manchester in the United Kingdom, with an Erasmus scholarship from the European Commission.

The protein is now known to interact with and control dozens of different genes and proteins, and it helps regulate the cycle of molecular events by which cells grow and reproduce.

But in disease conditions like muscular dystrophies, satellite cells can't keep up with repeated cycles of injury and are ultimately exhausted or functionally impaired,» Hindi said.

«The overall sun - to - electricity efficiency of the hydricity process, averaged over a 24 - hour cycle, is shown to approach 35 percent, which is nearly the efficiency attained by using the best photovoltaic cells along with batteries,» Gençer said.

It was always «fun» to discuss and argue scientific matters with Kim — he is a very effective experimenter and, as everyone in the cell cycle field knows, an unusually bright mind.

It was unlikely that all 24 genes would be altered simultaneously in any one bacterium, so the cycle was repeated over and over to increase the proportion of cells with mutations in all 24 genes.

Therefore, a novel therapeutic approach in inflammatory breast cancer could involve a combination of conventional chemotherapy with small - molecule inhibitors of the Cdk2 cell cycle kinase.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

In the new study, Narula, Igoshin and collaborators set out to explain how B. subtilis times its sporulation decision with its cell - division cycle, a programmed series of events that cells normally follow to reproduce.

Endometriosis is caused by uterus lining (endometrium) cells moving elsewhere in the body where they can compress nerves and bleed in time with a woman's menstrual cycle.

But in addition to these factors, Hunt, who won a share of the 2001 Nobel Prize in physiology or medicine (along with Leland Hartwell and Paul Nurse) for his discovery of cyclin, a key regulator of the cell cycle, emphasizes early independence and playfulness.

It is therefore essential that there be control mechanisms capable of detecting errors in this process and halting the cell cycle with the aim of allowing the cell to repair the breakages or, if not possible, to eliminate the damaged cell.

Two - way fuel cells Meanwhile, Versa, a solid oxide fuel cell stack supplier, is working with Boeing and «a large European company» on an innovative reversible SOFC that cycles back and forth between providing power and electrolyzing water into hydrogen and oxygen, Stokes says.

Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.

Endometriosis is caused by uterus cells moving elsewhere in the body and bleeding in time with a woman's menstrual cycle.

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

In contrast, cells with a dilute electrolyte solution could only last for 6 cycles.

First, imaging experiments revealed that Tregs have a close relationship with the stem cells that reside within hair follicles and allow them to regenerate: the number of active Tregs clustering around follicle stem cells typically swells by three-fold as follicles enter the growth phase of their regular cycle of rest and regeneration.

But its morphology and / or cell cycle might have complexities more often associated with eukaryotes.

However, cells with active Myc can not stop the cell cycle engine and we think that the non-stop proliferation of the cells with low ATP content leads to prolonged activation of AMPK and p53.

In addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics such as signal transduction and cell cycle processes.

In people with diabetes, however, the cycle is broken: either insulin is not produced in response to a meal or the muscle and liver cells don't respond to the insulin (also known as insulin resistance).

Prof. Umeda found that inhibiting CDKs even with the absence of DNA damage would cause the Rep - MYB3R accumulation seen with DNA damage and stall the cell cycle before the M phase transition.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

The scientists involved with this study were able to demonstrate that translocations can occur within hours of DNA breaks and that their formation is independent of when the breaks happen during the cell division cycle.

Under the microscope the high point of the cycle is undoubtedly division itself, especially the stately dance of the chromosomes which ensures that each new cell is born with -LSB-...]

Recharging one of these primary cells could allow the battery to be reused, but the possible number of recharging cycles for such a cell is very limited — it performs more poorly with each recharge.

With this mechanism, scientists showed that they were able to extend the cycle life of the lithium - sulfur cell without compromising its performance.

When the researchers induced the clock cycles to shift with chemicals or slight changes in temperature, they found that the cells also varied in their adaptability to change, in keeping with the volunteers» reports of varying responses to jet lag and other disruptions.

The result: luminous cells whose light waxes and wanes in time with their internal cycle, allowing the researchers to watch the clocks at work.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

In addition, the parasexual cycle is induced between two a / a mating partners when mixed in ménage a trois matings with a limited number of α / α cells that serve as pheromone donors to trigger unisexual a-a reproduction [43].

We created a thin - film device that operates on the same principle but with two types of solid redox materials that produce a change in the potential difference in the cell over a heating and cooling cycle,» firstauthor Takayuki?Shibata says.

How the vital processes of cell cycle control (with the final event of cytokinesis) and signalling for cell wall biosynthesis are exactly coordinated remains to be determined.

Cells treated with palbociclib irreversibly withdraw from the cell division cycle and enter a state referred to as cellular senescence.

about Researchers correlate incidences of rheumatoid arthritis and giant cell arteritis with solar cycles

Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus.

«This idea fits nicely with the findings from a number of groups — that forced expression of cell cycle regulators can induce cardiomyocyte proliferation in mammals,» says Jopling.

The major mechanism of B cell suppression by MSCs is attributed partly to the physical contact between MSCs and B cells and in part to the soluble factors released by MSCs; this leads to the blocking of B cell proliferation in the G0 / G1 phase of the cell cycle with no apoptosis 28, 29, 30.

To uncover how groups of cancer cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed dishes of human pre-cancer and metastatic breast cancer cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.