Sentences with phrase «with cell fusion»

Not exact matches

The second part of this process is the fusion of the polar nuclei with a second sperm cell nucleus, thus forming a primary endosperm.

Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

With reckless ambition, I decided to add this fusion back into cells and then screen for mutants that could not either switch on or switch off the response to heat shock.

After a median follow - up of 11 months, 11 of the 13 patients who responded remain on the study, including one patient who had non-small cell lung cancer (NSCLC) with a ROS1 gene fusion who has had a complete response that has been maintained for more than two years.

Antibodies to fusin blocked cell fusion and infection with normal CD4 - positive human target cells.

Cancerous Marriage The fusion of tumor cells with white blood cells may be the secret behind how cancer spreads around the body.

Concerns about global warming and oil's imminent demise have caused scientists and policy - makers to look for solutions in both the future and the past: to new technologies such as nuclear fusion, multijunction photovoltaics, and fuel cells — and to traditional energy sources such as water power, wind power, and (sustainable) biomass cultivation (coupled with clean and energy - efficient combustion).

The scientists, Nicole King and Arielle Woznica of the University of California, Berkeley, with collaborators Jon Clardy and J.P. Gerdt at Harvard Medical School in Boston, discovered that within minutes after exposure to a chonodroitin sulfate (CS) lyase produced by V. fischeri, S. rosetta cells aggregate into mass mating swarms, entering into cell and nuclear fusion while duplicating and recombining their genetic material.

Cell fusion is a process in which one or more cells combine to form a new cell with more than one nuclCell fusion is a process in which one or more cells combine to form a new cell with more than one nuclcell with more than one nucleus.

This structure shows the two proteins (in red and gold) and sugars (in green) responsible for mediating HIV's fusion with its host cells.

«Making the movements of HIV visible so that we can follow, in real time, how surface proteins on the virus behave will hopefully tell us what we need to know to prevent fusion with human cells — if you can prevent viral entry of HIV into immune cells, you have won,» says Dr. Blanchard, who is also associate director of Weill Cornell's chemical biology program.

The finding that normal fertilization can result in embryos containing cells with different parental sets of chromosomes is a new mechanism for chimerism, which was previously thought to occur only as the result of fertilization errors, for example, the fusion of multiple sperm or eggs to form an embryo.

Nagoya, Japan — Dr. Daisuke Maruyama and Professor Tetsuya Higashiyama at the Institute of Transformative Bio-Molecules (WPI - ITbM) of Nagoya University and the JST - ERATO Higashiyama Live - Holonics Project along with their international team have shown by live - cell imaging techniques that flowering plants, such as Arabidopsis thaliana undergo a cell to cell fusion to prevent the attraction of the second pollen tube after fertilization has occurred.

According to new research, both processes rely on a single protein that enables the seamless fusion of two cells, such as a sperm cell and egg cell, or the fusion of a virus with a cell membrane.

To see what might go wrong with the telomeres of cloned animals between cell fusion and maturity, a team led by Lenhard Rudolph of the Hannover School of Medicine and Heiner Niemann of the Institute for Animal Science at Mariensee, Germany, tracked the length of telomeres during development.

Dolly was the only lamb born from 277 fusions of oocytes with udder cells.

Scientists have discovered a new «mastermind fusion gene» may be associated with a rare cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Atlas.

A phase I clinical trial and a phase III clinical trial have been completed for a T - cell based immunotherapy and IL - 13 bacterial toxin fusion protein respectively, both with promising outcomes.

In an important experiment published one year later, Jim Rothman, a Lasker Prize winner in 2002 honored for his work on fusion in non-neuronal cells, provided the experimental support for Scheller's idea by demonstrating that Scheller's VAMP, or as Rothman called it the v - SNARE, interacted with Scheller's syntaxin or t - SNARE, together with a second t - SNARE, to initiate fusion.

Koonin describes the eukaryotic cell as a «palimpsest of fusions and gene exchanges,» referring to a manuscript that has been written over with new text.

SGC0946 was found to selectively kills cells transformed with the MLL - AF9 fusion oncogene in an in vitro model of leukemia.

PCL - TCP composite scaffolds with marrow derived cell - sheets in a porcine spinal fusion model: Preliminary evaluation.

2 top - responding animals are chosen, and immune cells are harvested for fusion with myeloma cells yielding multiple hybridomas.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

The translational fusion constructs resulted in high levels of cytoplasmic proteins present in intestinal and epidermal cells on vesicular structures with the characteristic appearance of lipid droplets.

When a dish of mammalian cells is transiently transfected with a plasmid containing a fluorescent protein (fusion) there is huge variation in the fluorescence intensities of individual mammalian cells within the dish.

Changes in replication, nuclear location, and expression of the Igh locus after fusion of a Pre-B cell line with a T cell line.

Application of a novel biodegradable PCL - TCP composite with stem cells in lumbar interbody fusion.

Additionally, they are engineered with glycoproteins on their surface that mediate binding and fusion with the membrane of a wide range of target cells.

We have undertaken a genome - wide functional screen on a mouse muscle cell line and identified hundreds of molecules implicated in the fusion of this cell line, with no effect on their proliferation or differentiation.

Total cell lysates of HuH - 7 cells were incubated with GST or GST - Sp1 fusion protein — prebound glutathione - Sepharose 4B beads and the bound fractions were subjected to immunoblotting with antibody against DDX3 (top).

Disproving the claim, Camargo's work revealed that the seeming pluripotency of adult stem cells was in fact the result of their rare fusions with cells in adult tissues.

Transient assays were done in onion epidermal cells using the plant signal sequence fused to RBP and a GFP reporter (ssRBP - GFP fusion protein) with RBP fused to GFP as a control.

For the in vitro GST pull - down assay, 20 μL of glutathione - Sepharose 4B beads (Amersham Pharmacia Biotech) with immobilized GST or GST / Sp1 fusion proteins (4 μg each) were incubated with HuH - 7 whole - cell extracts (500 μg) at 4 °C for 6 hours.

Richard Scheller has used a combination of biochemistry, molecular biology, and cell biology to identify several key synaptic vesicle and plasma membrane proteins involved in fusion of the neurotransmitter - containing vesicles with the membrane of the presynaptic terminal.

«This is the first demonstration using such a vesicle fusion process for delivering insulin that employs insulin - containing vesicles like those found in a beta cell and can reproduce the beta cell's functions in sensing glucose and responding with insulin «secretion»,» says Zhaowei Chen, lead author on the study.

The core will provide assistance with project design, testing of BioID - fusion proteins, establishment and testing of cells expressing BioID - fusion proteins, large scale BioID pull - downs, arranging for candidate identification by mass spectrometry and data analysis.

By transplanting Wnt - activated hematopoietic stem and progenitor cells (HSPCs) we demonstrated that Muller cells can be reprogrammed in vivo after fusion with HSPCs.

Also, genes that code for receptor tyrosine kinases, a family of receptors on the surface of cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.

Somatic cells can be reprogrammed either by nuclear transfer into oocytes or by fusion with embryonic stem (ES) cells.

In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

Furthermore, we demonstrated cell - fusion mediated reprogramming as an efficient therapy for Parkinson's disease, and as mechanism to control liver regeneration, an organ with high regenerative capacity in mammals (Altarche - Xifro et al eBiomedicine 2016; Pedone et al..

For Oct4 - GFP fusion overexpression, cells were plated in 4 - well Chamber slides (Nunc) and transfected with 1.6 µg total DNA, containing 0.8 µg Oct4 - GFP fusions, as described above.

Sperm cells can not divide and have a limited life span, but after fusion with egg cells during fertilization, a totipotent zygote is formed with the potential to develop into a new organism.

These cells return to a precursor stage following their spontaneous fusion with transplanted haematopoietic stem and progenitor cells in damaged retinas.

Methods to reprogram primate somatic cells to a pluripotent state include somatic cell nuclear transfer [2], somatic cell fusion with pluripotent stem cells [3] and direct reprogramming to produce induced pluripotent stem cells (iPSCs)[4]--[10].

Structures at the end of chromosomes called telomeres protect cells from deterioration or fusion with other chromosomes.

* Duration of a few weeks * An average dose more equivocal to a «loading» phase than a «maintenance phase» * A larger dose for potential responders who lack natural, dietary creatine * A smaller dose for potential non-responders with a significant amount of existing dietary creatine intake * A training protocol that emphasizes all phases of muscular energetics to take advantage of the ATP - CP, glycolytic, and oxidative effects of creatine supplementation (HIIT is ideal for cardiovascular exercise when supplementing creatine, due to the repeated bouts of high intensity work) * A training protocol that incorporates negatives in order to stimulate satellite cell fusion, as per Dr. Hatfield's theory of holistic training * A training protocol that emphasizes repeated bouts of work per the results of creatine studies * A nutrition protocol tailored to reduce post-workout cortisol levels, which would involve a post-workout shake and possible glutamine supplementation * A nutrition protocol that takes advantage of carb - load (super compensation) near the end of the cycle

Dragon Ball Fusions: New Musical Commercial Dragon Ball Fusions: Universe 6 Characters Confirmed, Trailer of New Fusions Dragon Ball Fusions: Towa Fused with Arale Dragon Ball Fusions: Beerus x Whis, Cell x Frieza, and More Fusions Dragon Ball Fusions Gets Second Trailer, Release Date Dragon Ball Fusions, New Dragon Ball Z Game, Gets First Trailer Dragon Ball: Project Fusion — New Manga in Works, Fuse Stages, Any Character Dragon Ball: Project Fusion — New 2016 RPG Game

As the Sole Survivor (the first fully - voiced protagonist in the Fallout series) in Boston's post-apocalypse wasteland, you'll take on Feral Ghouls, Raiders, Syths and Bloodbugs and more with high - powered weaponry that includes the Fat Man mini nuke cannon and the fusion cell - powered Laser Musket.