Sentences with phrase «with cell loss»

So we might just be able to deal with cell loss if we had a sufficiently sophisticated program of stem cell replenishment — using cells engineered to lack the one linchpin function for cancer, namely telomere elongation.

Not exact matches

By paying your monthly cell phone bill with the Uber credit card, you will be reimbursed for up to $ 600 in losses if your phone is damaged or stolen.

«It was the older meditators who had brains that seemed particularly well preserved, suggesting that meditation provides protection against the brain cell loss associated with aging,» notes the BPS.

• Loss - In - Weight: The compact trapezoid shape is identical to both the volumetric & gravimetric feeder with either a single high performance digital or analog load cell.

For example, the loss of cell phone, video game privileges, or time with friends.

But while chemotherapy and radiation are associated with temporary changes, such as hair loss and tissue swelling, the treatments can have an unseen, permanent effect: infertility due to irreparably damaged sperm or egg cells.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

Immune and fat cells in the scalp are obviously also involved in hair loss along with the cells of the hair follicle.

Two people with severe sight loss can now see well enough to read after receiving tissue grown from human embryonic stem cells.

Although amyloid clogs the brain early on, memory loss tracks much better with a different protein, tau, which forms so - called «tangles» within nerve cells.

«We came up with a list of potential cellular candidates that could be compensating for the loss of these specific macrophages and used several different tests to determine which cells were clearing away the nerve debris after injury,» Lindborg said.

Loss of LKB1 by regulatory T cells was also associated with increased levels of signaling molecules or cytokines associated with the Th2 immune response, Kai said.

Adams is partnering with doctoral student Sambuddha Basu, associate professor and neurosciences researcher, Associate Professor Yoon - Seong Kim, and scientist Subhrangshu Guhathakurta to study Parkinson's, which affects motor functions caused by a gradual loss of brain cells.

Twelve people with Stargardt's macular dystrophy will be treated with retinal cells made from human embryonic stem cells (hESCs) in the hope of improving, or at least halting loss of sight.

After suppressing mitochondrial function using the drug antimycin, Chen and Birsoy saw that cells with mutations inactivating the gene ATPIF1 were protected against loss of mitochondrial function.

They experienced further improvements in beta cell function and insulin sensitivity in muscle tissue, but neither insulin sensitivity in the liver nor adipose (fat) tissue continued to improve with the greater weight loss.

In Parkinson's the pathways are thought to be out of balance, with interrupted motor cells causing the debilitating tremors and loss of movement control symptomatic of the disease.

Aging is associated with the gradual loss of brain cells, sleep disturbances and declining memory function, but how these factors are related to each other has been unclear.

Loss - and gain - of - function assays confirmed that cells with loss of KDM6A are vulnerable to ELoss - and gain - of - function assays confirmed that cells with loss of KDM6A are vulnerable to Eloss of KDM6A are vulnerable to EZH2.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

In people with vitiligo, which causes patchy loss of pigmentation, a certain kind of T cell is dominant in the afflicted areas of skin; patients with psoriasis, on the other hand, exhibit an increase in another kind of T cell.

In order to reduce these large energy losses and raise efficiency, Professor Kita's research team used two small photons from the energy transmitted through a single - junction solar cell containing a hetero - interface formed from semiconductors with different bandgaps.

The SOFC, referred to as a third - generation fuel cell, has been intensively studied since it has a simple structure and no problems with corrosion or loss of the electrolyte.

Treating these cells with guanabenz prevented myelin loss and restored cell survival to near normal levels.

Optical Coherence Tomography (OCT) imaging revealed the loss of outer segments in foveal cone cells in the «optical gap» of a patient with ATF6A defects.

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.

«The stem cells would mature into bone and become a permanent fix for patients with hearing loss.»

When the researchers counted dead hair cells, the numbers suggested that the nine animals untreated with supplements experienced a 50 - dB loss in hearing.

Accelerated cell loss in patients with FECD prevents clearing of the cornea, and if left untreated, may progress to blindness.

Ozone treatment caused no changes in the PLGA and no loss of function, with cells still able to grow on the polymer scaffold, as they would in treatments.

«It's easy to see how a loss of adult stem cells might accrue over a lifetime and accelerate with aging.

After infection with CMV, these mice developed profound hearing loss and lost a significant amount of outer hair cells, which are found in the ear and play an important role in hearing.

Immune system cells known as natural killer (NK) cells play an important protective role against hearing loss in mice infected with cytomegalovirus (CMV), according to a new study published in PLOS Pathogens.

The most severe cytopathic effects were observed 48 hours after infection, with a larger number of rounded, swollen cells, more syncytium formation and pronounced loss of cell integrity, all of which denote cell death.

In contrast, CMV - infected mice with functional Ly49H had minimal loss of hearing and hair cells.

Two men with prostate cancer, cells in a petri dish, a loss of function that may or may not translate into pathogenicity: This does not merit my mental energy.

A research advance co-led by Case Western Reserve University School of Medicine's Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory «hair» cells in the inner ear.

However, with each round of cell division, telomeres shorten, resulting in a gradual loss of genomic stability.

At that point, the researchers began monitoring the repair process with longitudinal fluorescence to determine if there would be an appreciable loss of stem cells in the in vivo samples, as compared to the static, in vitro, environments.

He added: «The fact that all vertebrates regenerate their teeth in the same way with a set of conserved stem cells means that we can use these studies in more obscure fishes to provide clues to how we can address questions of tooth loss in humans.»

Results of the investigation have numerous uses in the field of hydrogen fuel cell vehicles as well as the chemical industry, as this new method is capable of generating hydrogen from methane gas and electricity in just one step and with near - zero energy loss.

Glaucoma specialists attempt to track the vision loss caused by ganglion cell death with visual field testing.

Loss of sight in patients with glaucoma is caused by the death of cells in the retina at the back of the eye.

Compared with a control T cell (left), loss of Rab27a (right) blocks the delivery of late endosomes (red) to the plasma membrane, inhibiting the recruitment of Gag (green) to HIV - 1 assembly sites.

Unlike for ccr5, there are no known humans with loss of function cxcr4 mutations that would provide insight into the safety and viability of cxcr4 disruption in mature CD4 + T cells.

In our studies, we observed hyperglycemia and impaired glucose tolerance in the Tg - hIAPP mice treated with IAPP aggregates, which occurred concomitant to a significant loss of β cells (> 60 %).

In the humanized mouse model under the conditions studied here, partial loss of cxcr4 in human T cells due to treatment with X4 - ZFNs provided selective pressure for either the evolution or emergence of a pre-existing single amino acid mutation in the V3 loop of the infecting X4 HIV - 1 strain that enabled it to use CCR5 as efficiently as CXCR4.

Dysfunction and loss of β cells has been associated with glucolipotoxicity (Poitout and Robertson, 2002; El - Assaad et al., 2003), islet cholesterol accumulation (Brunham et al., 2010), and islet inflammation (Donath and Shoelson, 2011).

«These results suggest that inflammation in mid-life may be an early contributor to the brain changes that are associated with Alzheimer's disease and other forms of dementia,» said study author Keenan Walker, PhD, of Johns Hopkins University School of Medicine in Baltimore, Md. «Because the processes that lead to brain cell loss begin decades before people start showing any symptoms, it is vital that we figure out how these processes that happen in middle age affect people many years later.»

Thus, our results strongly suggest that substantial loss of β cells is the likely cause of the diabetic phenotype in the animals treated with IAPP aggregate - containing materials.