Sentences with phrase «with cell repair»

Although this protein doesn't contain all the essential amino acids, it does contribute to your total daily protein intake to help with cell repair and growth.

Not exact matches

-- Taki Skouras, CEO of Cellairis, a cell phone repair and accessories brand with 500 locations across the U.S. and which has expanded internationally to Canada, Jamaica, Brazil, Ecuador, Mexico, and Dubai, for a total of more than 600 company - owned and franchise locations

Provides repair services for computers, cell phones and tablets, while assisting businesses with networking and IT services.

This makes me happy: Microglia cells migrate into tumors and supply cancer cells with a substance needed for the repair of DNA damage.

Duly reverential, the panel satisfied itself with simply listing all the research possibilities, including the improvement and increased safety of IVF, the creation of cell lines that might someday be useful for bone marrow transplantation, repair of spinal cord injuries, skin replacement and, naturally, the hint of a greater understanding of cancer.»

The body wears out, mutations accumulate faster than can be repaired just through the natural process of cell division, cancer grows, arthritis wracks the world worn joints, the child born with tetralogy of Fallot away from surgical care dies.

When a cell divides, chromosomes line up with similar mates such that if one chromosome is scrambled, it can use its counterpart as a template for repair.

A type of immune therapy known as PD - 1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the system cells use to spell - check and fix errors in DNA (SN Online: 10/7/15).

Mice with fragile beta cells that were poor at repairing DNA damage would rapidly develop diabetes when those beta cells were challenged by cellular stress.

The secret to repairing our tissues and growing new organs is getting all touchy - feely with cells

Other mice, with robust beta cells that were good at repairing DNA damage, were able to stay non-diabetic for life, even when those islets were placed under severe cellular stress.

Previous researchers have also used cell transplant technologies to repair injured hearts, but these used CMs organized in two dimensions with a random, myofibril structure, which is different from natural heart tissue.

One exciting potential for Permacol is that it can be seeded with the patient's own cells, so that in the future it may be possible to repair cartilage or bone by seeding with chondrocytes or osteocytes.

(Previously, scientists had used CRISPR / Cas9 to repair mutations that affect smaller numbers of people with Duchenne, and in cell types that weren't necessarily clinically relevant.)

«For this reason, we decided to combine vitamin C with a PARP inhibitor, a drug type known to cause cancer cell death by blocking the repair of DNA damage, and already approved for treating certain patients with ovarian cancer.»

And five months later, Jerry Shay and Woodring Wright of University of Texas Southwestern Medical Center, also working with Geron collaborators, published additional findings, showing that, by introducing the hTRT gene to cells, they could make those cells repair unraveling telomeres.

Injecting CRISPR / Cas9 along with sperm (bottom row) repairs the mutation before DNA replicates, leading to an embryo with all healthy cells.

Read more: «Diabetic rats cured with their own stem cells ``, «Baby repair kit found inside the womb» and «Regenerating a stem - cell ethics debate ``

The embryos lacking functional BRCA2 genes probably stopped growing because molecular «checkpoints» in the developing embryo either halt the division of cells with damaged DNA, so that the damage can be repaired, or kill the cells outright.

With a less efficient helicase and therefore less efficient DNA repair, Martin suggests, atherosclerotic lesions could arise like tumors from mutations in single cells, besides their well - known origin from chronic inflammation from high - fat diets.

NERVE cells with huge potential for treating paralysis could be made from a person's own skin or hair follicles, making spinal repair a more realistic prospect.

Of 54 injected embryos, 13 were patchwork, or mosaic, embryos with some repaired and some unrepaired cells.

Work with skin cells reprogrammed to mimic embryos had suggested the mutation would be repaired in fewer than 30 percent of cells.

Cells in the bone marrow then pick up the signal and pre-program monocytes with the appropriate function to either protect or repair.

Now, results described in tomorrow's issue of Nature suggest that BRCA2 mutations could lead to cancer by interfering with cells» ability to repair damaged DNA.

Synthetic biocircuits made of DNA and encoded proteins could be inserted to detect and repair (or kill) cells with mutations known to cause cancer or aging.

«No reliable approach is currently available for complete restoration of damaged articular cartilage,» said Dr. Bai - wen Qi, «in this study, CS / PVA gel was combined with rabbit bone marrow stromal cells (BMSCs) transfected with hTGFβ - 1 and used to repair rabbit articular cartilage defects and the repair effect was evaluated.»

Now, with new kinds of technologies that are coming up, new types of tissue engineering and, you know, some of the hopes that people have for stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

Injury to the brain stimulates the production of new neurons, but these new cells are sometimes hyperexcitable, disrupting neural circuits and causing recurring seizures, researchers with UT Southwestern's Texas Institute for Brain Injury and Repair reported in Nature Communications.

The scientists, led by Dr Paul Genever in the Arthritis Research UK Tissue Engineering Centre in the University's Department of Biology, have developed a technique to rejuvenate cells from older people with osteoarthritis to repair worn or damaged cartilage thus reducing pain.

Rad3 signalling ensures that cells do not divide before DNA damages are repaired and thus provides cancer cells with a mechanism to resist chemotherapy by repairing these DNA damages.

It is therefore essential that there be control mechanisms capable of detecting errors in this process and halting the cell cycle with the aim of allowing the cell to repair the breakages or, if not possible, to eliminate the damaged cell.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.

All of these findings were supplemented with several other experiments that were designed to learn how CHI3L1 interacts with other cells involved in the tissue repair response in both human and mouse lungs.

Importantly, like cancer cells with other mutations in the HR repair pathway, CHD1 - depleted prostate cancer cells proved to be hypersensitive to chemotherapeutic drugs causing DNA breaks, such as Mitomycin C, Irinotecan and PARP inhibitors.

These protein aggregates — called Huntington's aggregates — have been linked to problems with the repair system that nerve cells rely on to fix proteins that fold incorrectly: the cell's so - called protein folding response.

DDRs inhibition with a tyrosine kinase inhibitor appears to insulate the brain via blood - brain barrier repair, which prevents harmful immune cells that circulate in the body from getting into the brain where they can indiscriminately attack and kill healthy and sick neurons, like those that have been unable to perform autophagy to «take out their trash,» says Moussa.

But even more far - ranging treatments may be possible with embryonic stem cells, the blank - slate cells that give rise to all organs and tissue types and that (theoretically) can repair all forms of organic damage and disease.

Twenty - five years from now, our kids will only know some diseases, such as osteoporosis, from old books, and by then we will probably know how to repair tissues with stem cells.

Mark Poznansky, MD, PhD, director of the MGH - VIC and senior author of the Wound Repair and Regeneration report adds, «Having a novel therapeutic that is based on the immediate isolation of a patient's own cells, with minimal manipulation, will represent an attractive option for the wound care field; and a successful option that accelerates healing would greatly benefit patients, as diabetic ulcers typically need up to a year or more heal.

In particular, it has been shown that cells with other HR repair pathway defects, such as BRCA mutations frequently found in breast and ovarian cancer, are sensitive to inhibition of the enzyme PARP, and the PARP inhibitor Olaparib has been approved for treatment of BRCA - mutated ovarian cancers.

By combining different fractions in a trial - and - error fashion with the known NER proteins, Wood's team eventually identified the simplest mixture that would repair DNA in the test tube (Cell, vol 80, p 859).

When the stem cells were manipulated in animals with TMJ degeneration, the cells repaired cartilage in the joint.

The scientists have been able to show that the corneal epithelial cells can be cultivated and transplanted onto the eyes of rabbits with experimentally induced blindness to surgically repair the front of the eye.

In vitro experiments used human colon carcinoma cells with and without MMP9 and mouse embryonic fibroblasts, which are connective tissue cells that make the extracellular matrix and collagen and play an important role in tissue repair.

«The spectrum of tissues at risk for transformation when harboring a p53 mutation include many of those that we would like to target for repair with regenerative medicine using human pluripotent stem cells,» said Eggan.

Microglial cells normally help with repair in the body, but when over-activated they can promote unhealthy inflammation.

«We don't know what it actually does in the cell — what activates it, what it interacts with, and the specific type of DNA damage it repairs,» she says.