Sentences with phrase «with cellular processes»

Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes.

Not exact matches

It boosts circulation which helps the process of metabolism on a cellular level and supplies muscles, organs and bones with what they need to work efficiently.

In the above article the words: cellular, hormones, brain and nervous system appear by the second paragraph with absolutely no references to explain how these biological terms or processes relate to birth or birth trauma.

This correlated with a global reduction in arginine methylation, which controls multiple cellular processes, including DNA replication and DNA repair.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Close collaboration between the Pasteur Institute and Inria, taking the form of the InBio join research group, whose aim is to develop a methodological framework for achieving a quantitative understanding of the functioning of cellular processes, is the perfect illustration of the value of interdisciplinary research combining experimental approaches with methodological developments.

Researchers from the Pasteur Institute and Inria, with researchers from the CNRS and Paris Diderot University, and from the Institute of Science and Technology (IST) in Austria, have published two articles in Nature Communications about computer control of cellular processes.

It is still a long road to approved therapies but a growing body of basic research is fueling a search for drugs that interact with cellular cleanup processes to provide one - size - fits - all approaches for treating a megaclass of brain disorders.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

«May we not feel,» he wrote, «that in the virus, in their merging with the cellular genome and reemerging from them, we observe the units and process which, in the course of evolution, have created the successful genetic patterns that underlie all living cells?»

Thawing caused ice crystals to form and prevented meiosis, the cellular process during which an egg's chromosomes split up from 46 to 23, to be united later with 23 chromosomes from a sperm cell.

The team also showed that the cellular process macropinocytosis, which participates in cell scavenging nutrients and vesicles, contributes to exosomes uptake in cancer cells with mutant KRAS.

With illnesses that involve more vital organs and more basic cellular processes, the chances of healing are less.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Izpisua Belmonte added that more extensive studies will be needed to fully understand the role of heterochromatin disorganization in aging, including how it interacts with other cellular processes implicated in aging, such as shortening of the end of chromosomes, known as telomeres.

Last, the investigation of informational processing and cellular machineries have revealed that genomes of Asgard archaea, which affiliate with eukaryotes in the tree of life (see the figure), encode proteins that they only share with eukaryotes.

«With very specific spatial information, we could be better informed about how cellular processes or therapies involving oxidation are going to operate.»

When researchers suppressed the ARF gene in mole - rat cells during the reprogramming process to iPSCs, the cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse cells.

If researchers can unlock the secrets of this cellular process, therapies that replace diseased cells with healthy ones may one day be possible — brain - cell transplants to combat Alzheimer's, for instance, or even the creation of whole organs from scratch.

«While more work is required to elucidate the cellular and molecular mechanisms through which B cells exert their beneficial function in wound healing, we are in the process of obtaining the required regulatory approvals to conduct a first clinical study in patients with diabetic foot ulcers.

«The flexibility of this system means it can be adapted to explore other cellular processes while minimally interfering with other physiological or biological functions.»

In prior, unrelated experiments, the same species of worm had become hypersensitive to smell when its nerve cells experienced problems with dopamine signaling, a cellular process that helps control how readily cells can communicate with one another.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

Such experiments suggest that deletion of cellular activity, even for a brief time, «is causally involved with a pathological process like narcolepsy,» Boyden said.

The detailed study of such fundamental cellular processes is crucial for the understanding of diseases that go hand in hand with these events — in the case of autophagy, Alzheimer's disease or cancer.

But with age, the balance tips, as mitochondria and other cellular processes produce excess free radicals and the body's antioxidant defenses can't keep up, Rossman said.

«We also managed to confirm observations from previous microscopy studies that suggested that cellular regeneration shares similarities with the process of cell division.

Manipulating biological processes with minimal interference, from the cellular level to the behavior of whole organisms, is a burgeoning scientific effort to better understand how living things work and to develop more effective treatments for a range of medical disorders.

«The idea is to initiate specific biochemical processes in cells by flipping a magnetic switch,» says Jon Dobson, a biomedical engineer who has been manipulating cellular function with magnetic particles for more than 10 years at Keele University in Staffordshire, England.

«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.

Powerful new microscopy techniques enable researchers to observe the whole process in living cells, with bright fluorescent tags highlighting the chromosomes and other cellular components.

Researchers at the University of California San Diego School of Medicine, with colleagues in Pennsylvania and China, report that not only are there distinct differences in key cellular processes and molecular signatures between rheumatoid arthritis (RA) and osteoarthritis (OA) but, more surprisingly, there are joint - specific differences in RA.

The microbe seems to be able to replace phosphorus with arsenic in some of its basic cellular processes — suggesting the possibility of a biochemistry very different from the one we know, which could be used by organisms in past or present extreme environments on Earth, or even on other planets.

It supports proposals that use different technologies to build up knowledge of functional mechanisms and intracellular dynamics with atomic structure information and integrate these into an understanding of cellular processes in the native environment and in real time.

In the past 27 years, we have found that this cycling sugar modification of proteins — called O - linked N - acetylglucosamine, or O - GlcNAc — is nearly as common as protein phosphorylation and often competes with it at the same or proximal sites on proteins to regulate nearly every cellular process in response to nutrients and stress.

Because these processes are ultimately mechanical in nature, our focus is developing and applying new laser - based optical instrumentation with high - resolution microscopy imaging to understand cellular mechanics.

I think about how certain fundamental cellular processes or organs interact with one another, and how they all fit together, so it helps me frame some of my scientific questions.

Antibiotics stop or interfere with a number of everyday cellular processes that bacteria rely on for growth and survival, such as:

«We believe it is the first example illustrating the process of a developing human heart chamber in vitro,» said Kevin Healy, PhD, a UC Berkeley professor of bioengineering, who is co-senior author of the study with Bruce Conklin, MD, a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor of medical genetics and cellular and molecular pharmacology at UC San Francisco.

Scientists look at the structure, function, and evolution of genes (genomics), analyze the interactions with proteins these genes produce (proteomics), and systematically track the chemical traces of cellular processes (metabolomics).

We hypothesize that upon retinal neuronal damage MG or RPE cells undergo defined and controlled changes in cellular and molecular phenotype towards a cell with progenitor properties — this process that we are studying we call regenerative reprogramming.

LAMP2A: The A variant of lysosome - associated membrane protein 2 is a receptor involved in the cellular maintenance processes of autophagy, but levels decrease with age, and in at least some species this appears to be one of the factors involved in the age - related decline of autophagy.

Along with the cellular genes emphasized from the microarray analysis, two genes that are suspected to be involved in the scleractinian coral calcification process were tested for expression (Figs. 5A and 5B).

With scientists just starting to unveil the molecular frameworks for cellular processes, «we have no clear pictures of what the stem cells are doing throughout the day,» he says.

However, these two life - sustaining processes, which often unfold simultaneously on the strands of DNA, pose a spatial quandary: The cellular machinery that replicates DNA and the one that transcribes genes can collide head - on, destabilizing the genome with disastrous consequences.

Autophagy is a cellular process that plays an important role during the development and maintenance of tumors, providing them with the metabolic plasticity to meet their energetic needs, and requirements for cellular building blocks.

Living cells use phosphate to transport cellular energy with adenosine triphosphate (ATP), necessary for every cellular process that uses energy.

Genes, Genetics & Genomics (G3) symposium Our colleagues from the First Faculty of Medicine of the Charles University in Prague together with the Institute of Hematology and Blood Transfusion are organizing one - day symposium dedicated to recent discoveries on physiological as well as pathological cellular and molecular processes.

Dr. Loftus» research is aimed at understanding how the human genome regulates gene expression, with a focus on how this controls the cellular processes governing mammalian development.

Additionally, by engineering FP fusions associated with cellular organelles, scientists have been able to study many cellular processes, including mitosis, mitochondrial fission / fusion, nuclear import, and neuronal trafficking.