Sentences with phrase «with change in treatment»

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMA.

Not exact matches

While Jobs's treatment of his first child, Lisa, was deemed to be seriously lacking (with good reason) in Walter Isaacson's biography Steve Jobs, and the silver screen film adaptation that followed, he apparently had changed his parenting ways with the three children he raised with his wife Laurene Powell Jobs.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These individuals are likely to stick with the old rules — generally speaking, it would only make sense to change to the new tax treatment if the ex-spouse paying the support is in a lower tax bracket than the recipient.

The big increase in the in the last six months of 2012 was because of tax changes, with entrepreneurs and companies trying to close deals before New Year's to take advantage of capital gains treatment, John Guzzo, managing director of Berkery Noyes, said.

Over the past two decades, Dr. Bear, a researcher and surgeon, has led international trials that have resulted in major changes in the treatment of breast cancer and dramatically increased the chance for breast conservation among women with breast cancer.

The relationship... is seen as one that fluctuates with the changing needs, growth of family members, changes in family composition, and stress and crisis» «Marital Conflict: Its Course and Treatment — As Seen by Caseworkers,» Social Case - work, April, 1966, p. 212).

Already a movement is under way to improve end - of - life care by educating health - care providers to respond better to the needs of dying patients, by creating new care settings or improving existing ones, by seeking changes in methods of paying for appropriate care, by educating the public through conferences, town meetings, television programming, and even Web sites (see www.careproject.net), by providing adequate relief of pain, by withholding or withdrawing treatments that only prolong dying, by keeping company with those who are lonely, and by being a resource of meaning and hope for those tempted to despair.

Creative writing in schools gets very mixed treatment: while it is privileged at key stage 2 and, to a certain extent, at key stage 3, it usually receives less attention at key stage 4 and almost none at key stage 5 (though there are signs of change here with a renewed emphasis on recreative writing as an A Level coursework option).

Smurfit Kappa's sustainability report, which measures year - on - year progress with a focus on five priority areas (Forest, Climate Change, Water, Waste and People), shows that over the past ten years the packaging giant has also achieved a significant reduction in the amount of waste sent to landfill and has invested $ 60 million in water treatment plants.

There is a Central Market in our area that is helping me with my change to a Paleo way of living after my treatment of estrogen related breast cancer.

Powered by billions of earthworms working rapidly in concert with beneficial microbes, the BIDA ® System will begin processing Fetzer Vineyards» wastewater during the 2016 harvest season, accruing energy savings up to 85 % over current wastewater treatment technologies and optimizing water conservation measures in support of the fight against climate change.

With the Tinkerman famously not being much of a tinker after all in a campaign where he only made a handful of changes to his starting line - up, many people attributed Leicester City's success last year to the luck they had on the treatment table, which made it all the more unfathomable.

The Portugal forward hurt his left thigh when colliding with Kiko Casilla following a push from Dani Carvajal and, after receiving treatment on the field, threw a water bottle in anger as he headed for the changing rooms.

Ok, I take issue with number 1... as someone who was only able to nurse on one side after treatments for breast cancer, I can definitely say in my case nursing has changed my breast and made it more saggy.

Except if there are medical reasons which require care and adequate treatment, all problems with diaper changes can be solved in the easy and simple way.

Keep in mind that some infants do need treatment and don't improve just with making positional changes.

Treatments may have to be aggressive with changes in diet and a boosting of the overall immune system even after all symptoms are gone.

The «cold silent treatment» is just as obvious to children, since parents who suddenly do not speak to each other, or who are no longer affectionate with each other mark a significant change in a child's eyes.

With regular treatment you will notice a visible change in your hair, and significantly less frizz too, which is a sweet bonus.

Birthing from Within Advanced Mentor Retreat with Virginia Bobro, 2017 Doula Trainings International Doula Training with Jackie Davey, 2017 Creating a Culture of Breastfeeding in the NICU with BreastfeedLA, 2017 Diversity, Determinants, and Disparities in Maternal Mental Health, 2017 Hypnobirthing for Birth Professionals with Ellie Shea, 2017 (certified 2017) Working with Diverse Populations in Maternal and Child Health with Shafia Monroe, 2017 Changing the Paradigm: Social and Historical Trauma, 2017 Seeking Safety with Treatment Innovations, 2017 Holding Space for Pregnancy Loss with Amy Wright Glenn, 2017 Working with Childhood Trauma with Echo Parenting, 2017 Breastfeeding Full Circle with Dr. Jack Newman, 2016 Art of Sacred Postpartum and Mother Roasting with Sara Harkness, 2016 (certified 2017) Birth Story Medicine Part I with Pam England, 2016 Supporting Perinatal Mental Health as a Doula with Sonia Nikore, 2016 Prenatal and Postpartum Nutrition with Elizabeth Kotek, 2016 Sacred Blood Mysteries Online Class with Sacred Living, 2016 Birthing from Within Introductory Workshop with Virginia Bobro, 2016 Supporting Breastfeeding as a Doula with Kate Zachary, 2016 Homebirth Caesarean Workshop with Courtney Jarecki, 2016 Return to Zero Training for Supporting Fetal and Infant Loss with Kiley Hanish and Ivy Margulies, 2016 Acupressure for Pregnancy, Labor, Birth and Postpartum with Abigail Morgan, 2016 Becoming Dad Workshop with Darren Mattock, 2015 Diversity Roundtable for Birth Workers with Debra Langford, 2015 Babywearing for Doulas with Laura Brown, 2015 Co-leader, BabywearingLA, 2014 - 2016 DASC Director of Hospitality, 2014 - 2015 Co-leader, Silver Lake meeting of the International Caesarean Awareness Network, 2013 CAPPA Lactation Educator Training with Christy Jo Hendricks, 2013 (certified 2015, recertified 2018) Acupressure for Labor and Birth with Abigail Morgan, 2013 Essential Oils for Doulas with BluJay Hawk, 2013 Babywearing for Birthworkers with Laura Brown, 2013 Rebozo Techniques with Angela Leon, 2013 Massage Techniques for Doulas with Jenna Denning, 2013 Breeches, Twins and VBACs with Stuart Fischbein, 2013 DASC co-Director of Development, 2012 - 2013 Co-founded Two Doulas Birth, 2012 Spinning Babies Training with Gail Tully, 2012 Featured as the Doula Expert in LA Parent Magazine, 2012 Advanced Doula Training with Penny Simkin, 2012 CAPPA Postpartum Doula Training with Darla Burns, 2012 (certified 2014, recertified 2017) Yoga Instructor, Yogavidala, Los Angeles, CA, 2011 - 2012 Billings Ovulation Method Teacher Training, 2011 CAPPA Labor Doula Training with Angie Whatley, 2010 (certified 2011, recertified 2014, recertified 2017) CAPPA Childbirth Educator Training with Angie Whatley, 2010 (certified 2011, recertified 2014, recertified 2017) Neonatal Resuscitation Program Workshop with Karen Strange, 2010 (certified 2010) Herbs and Homeopathics in the Care of Women and Infants, 2010 The Farm Midwifery Center Midwife Assistant Workshop with Ina May Gaskin, 2009 Birthing from Within Introductory Workshop with Pam England, 2009 Iyengar Yoga Introductory I Assessment passed, 2010 Yoga Instructor, Eastern Sun Yoga, Memphis, TN 2008 - 2011 Yoga Instructor, Evergreen Yoga Center, Memphis, TN, 2009 - 2011 Eastern Sun Yoga Iyengar Teacher Training with Lou Hoyt, 2008 - 2011 Audubon Yoga Iyengar Teacher Training with Karin O'Bannon, 2010 - 2011

All body systems appreciate treatment after nine months of change, culminating with the delivery of the greatest miracle in life.

Most jaundice needs no treatment, but when it does, phototherapy (light therapy) is considered very safe and effective: Placing a baby naked in a bassinet, with his eyes covered, under blue «bililights» often does the trick, because ultraviolet light changes the bilirubin to a form that the baby can more easily dispose of in his urine.

Therapy treatments rooted in cognitive research focus on helping people change these negative thinking patterns and replace such thoughts with more positive and realistic ones.

The center has supported thousands of women to achieve their breastfeeding goals since its inception, performed lactation research, provided education on lactation topics to both parents and professionals, advocated for changes in breastfeeding policies and provided lactation therapy for the treatment of infant sucking problems and maternal breast and nipple problems with an over 95 % success rate.

A key requirement of democracy is equal protection of all stakeholders - i.e., if at some point there is a completely fair vote of 2/3 population preferring the choices advocated and implemented by party A; and 1/3 preferring the choices of party B - then a system must ensure that the minority gets adequate protections and fair treatment; so that while at this moment country gets steered to choice A, the minority doesn't get punished in any way for saying that in their opinion choice B might be best; and if some of the original voters change their mind, the choice B can still be known even if the governing clique that was elected on the idea of A wants to continue with A forever.

A real - time electronic poll of BME teachers attending the seminar found that: 78 % do not think the work and contribution of BME teachers is recognised and valued by schools; 58 % do not think treatment of BME teachers has improved in the last decade; Only 36 % feel outcomes for BME pupils have improved in the last decade; 98 % feel that racism continues to be a serious problem in the UK today; 53 % do not see themselves still being in the teaching profession in the next five years, with 31 % saying they are planning to change career and the rest saying they plan to retire or take a break from the profession.

Question topics during a post-announcement Q&A included the surprise resignation of Joe Percoco, the extensive list released today of New York endorsers of Hillary Clinton and Mayor Bill de Blasio's absence from that list, whether he supports de Blasio's call for changes to bail in light of the killing of Police Officer Randolph Holder, «felony drug dealers» being offered treatment instead of jail time, dealing with homeless people in the subway and rail systems, details of his executive order extending anti-discrimination laws to transgender people, Board of Regents Chancellor Merryl Tisch's departure and rules and laws around criminal defendant drug diversion programs.

«So the Department of Health has authorized to change the regulation to comply with the statue, to date — they have not and this continues to leave children in danger and without treatment.»

Also at 10 a.m., the Assembly will hold a public hearing to examine the status of inmates with mental illness in the state's prisons and local jails and to determine whether changes may be needed to appropriately address the treatment of mentally ill prisoners, Legislative Office Building, 2nd Floor, Hearing Room C, Albany.

Party may be prepared to change its focus in drug policy, with manifesto emphasising treatment rather than punishment

With his «Changing Lives» motto, President Mahama, will in the coming days, commission other major projects in Accra, including the new Ridge Hospital, inauguration of the James Town - Bukom ultra modern boxing arena, inaugurate the new liquid waste treatment plant, to make way for the eternal closure of lavender hill, which has been in existence for the past 60 years.

«If lithium's effect on the cerebellum is the key to its effectiveness as a mood stabilizer, then a more targeted treatment that causes the same change in the cerebellum without affecting other systems might be a better treatment for patients with bipolar disorder,» Wemmie says.

Along with those improvements, pain intensity decreased in the yoga group at all three time periods, while the delayed - treatment group had negligible changes.

«We have shown for the first time clear changes in brain activity in depressed people treated with psilocybin after failing to respond to conventional treatments,» says Carhart - Harris.

According to recent research, however, it may be the treatment of depression that actually causes personality changes in people with the disorder.

If hypofractionated radiation with curative intent can reduce the treatment time for lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this research could result in a change in the paradigm of how a large subset of locally advanced NSCLC patients are treated.»

In addition, starting SSRI treatment was associated with increased Indoles production, implicating changes in tryptophanase - producing bacteriIn addition, starting SSRI treatment was associated with increased Indoles production, implicating changes in tryptophanase - producing bacteriin tryptophanase - producing bacteria.

That changed last year, when researchers used two tools to diagnose the disease with nearly 100 percent accuracy in living subjects, a feat that might ultimately allow patients to seek drug treatment before their condition becomes too advanced.

In a change from longstanding practice, the CMS recently began suppressing substance abuse - related claims in the Medicare and Medicaid Research Identifiable Files to comply with a 1987 federal regulation barring third party payers from releasing information from federally funded substance abuse treatment programs without patient consenIn a change from longstanding practice, the CMS recently began suppressing substance abuse - related claims in the Medicare and Medicaid Research Identifiable Files to comply with a 1987 federal regulation barring third party payers from releasing information from federally funded substance abuse treatment programs without patient consenin the Medicare and Medicaid Research Identifiable Files to comply with a 1987 federal regulation barring third party payers from releasing information from federally funded substance abuse treatment programs without patient consent.

With two - thirds of its 2,000 employees working in R&D, the company is committed to applying its resources to game - changing treatments for serious diseases.

Russell Marx, director of Adolescent Eating Disorders Program at the University of California, San Diego, and chief science officer of the National Eating Disorders Association, expects to see big changes in diagnosis and treatment with the addition of binge eating disorder but less impact on anorexia diagnoses as the number of patients with ED - NOS is reduced.

A new study supported by the Milstein Medical Research Program at The Rockefeller University, however, has uncovered the molecular roots of skin discoloration that is often associated with psoriasis, suggesting the possibility of new treatments for pigmentation changes seen not only in psoriasis, but also in other conditions such as eczema and acne.

The PACE trial, published in The Lancet in 2011 [2], examined the effects of three different treatments for people with CFS, compared with usual specialist medical care (SMC): cognitive behaviour therapy (CBT, where a health professional helps the patient to understand and change the way they think about and respond to their symptoms), graded exercise therapy (GET, a personalised and gradually increasing exercise programme delivered by a physiotherapist), and adaptive pacing therapy (APT, where patients adapt activity levels to the amount of energy they have).

The researchers performed a «genome - wide» study in children with newly diagnosed CD, before any treatment, to look for possible epigenetic changes that may affect gene behavior.

«When you match physiologic changes in the brain with behavioral impairment, you can start to understand the biological mechanisms of this disorder, which may help improve diagnosis, and, in time, treatment.»

«This treatment has now been studied in our centre using the most sensitive measure of lung structure — a radiologic measurement of lung density — allowing us to detect changes far earlier than can be seen with standard breathing tests,» said Dr. Kenneth Chapman, Director of the Asthma and Airways Centre at Toronto Western Hospital and the Canadian research lead for the multicentre trial.

«What comes with sleep apnea are these changes in the brain, so in addition to prescribing continuous positive airway pressure, or CPAP — a machine used to help an individual sleep easier, which is the gold standard treatment for sleep disturbance — physicians now know to pay attention to helping their patients who have these other symptoms,» Macey said.

Treatment is with a change in dietary habits, laxatives, fiber therapy, enemas, and rarely surgery.

Some basic research findings are being translated into new treatments, and with the discovery of induced pluripotent stem cells in 2006, the field has seen a step - change in biological understanding that will affect the way new drugs are identified and tested and, potentially, the way cells can be generated in the lab.