Sentences with phrase «with changes in cell»

We found that parenting was associated with changes in TNF methylation as well as with changes in cell - type composition.

In contrast with the changes in cell signaling, muscle mRNA responses of selected genes associated with muscle proteolysis and catabolism were largely unchanged between treatments.

Not exact matches

When I spoke with Katelyn, she mentioned that while you can book, change and chat with your agent at any time and in real time, your itinerary is always available even with no cell connection or wifi available.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

A source familiar with the matter said the cell tower addresses were being sent to Google after a change in early 2017 to the Firebase Cloud Messaging service, which is owned by Google and runs on Android phones by default.

An encounter with Jesus in a prison cell changed everything.

(Cf. the phenomenon of the «runners» at first connected with the mother plant and then separated from it; the fluid transition between various plants and animals which appear to be one; the germ - cell inside and outside the parent organism, etc.) Living forms which present what are apparently very great differences in space and time can ontologically have the same morphological principle, so that enormous differences of external form can derive from the material substratum and chance patterns of circumstance without change of substantial form (caterpillar - chrysalis butterfly).

In the June 2010 issue of Nature Medicine, in an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he sayIn the June 2010 issue of Nature Medicine, in an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he sayin an interview with theBoston - based researcher, Daley tells how he further changed the focus of his work after Prof. Shinya Yamanaka of Kyoto University, who won the 2010 Kyoto Prize for advanced technology, made known his successes with iPS cells in 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he sayin 2007: «Once Yamanaka solved the problem, I turned around virtually my entire programme to take advantage of that breakthrough,» he says.

Also there is evidence of molecular mechanisms in the cell membranes that can amplify small changes in the field to produce large changes in neural activity.13 On the other hand, earlier tests of Kohler's theory found that interference with electrical gradients over the cortex had no effect on behavioral measures (see note 11 for reference to these studies).

Under Child's theory there is complete continuity from the reaction of the cell with its environment, which constitutes the primary metabolic gradient, and from the later reactions, by which the pattern of the developing embryo is laid down in accordance with the changing gradient pattern, to the intellectual processes by which the adult organism adjusts its relations to the outside world.

The change in load cell output occurring with time, while under load, and with all environmental conditions and other variables remaining constant; usually measured with Rated Load applied and expressed as a percent of Rated Output over a specific period of time.

The Home Secretary Theresa May has today revealed plans to change the Mental Health Act to stop children and young people with mental illness being detained in police cells.

He added: «The important thing is that you work with people who are like - minded and interested in pursuing the same sort of things where you can, and we will, whether the subject is stem cell or whether the subject is climate change.»

Scientists must seek a new, more energetic engagement with Americans if they are to overcome public skepticism on issues ranging from climate change to stem cell research, AAAS CEO Alan I. Leshner writes in a commentary in The Chronicle of Higher Education.

This allowed them to track changes in calcium ion concentrations in the cells around wounds in living tissue (as opposed to the cell cultures used in many previous wound response studies) and to do so with an unprecedented, millisecond precision.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer development.

The environment in which cells grow and develop can greatly influence their quality and function, but surprisingly little is known about how the ovarian stroma changes with age.

The results show — for the first time, Briggs thinks — that the bacterial genomes change with depth: the micro-organisms at 554 metres carry more mutations in genes that code for energy - related processes like cell division and biosynthesis of amino acids than are seen in their shallower counterparts.

«Our analysis revealed that the differences between tame and aggressive foxes may lie in cells in the anterior pituitary gland, which can change their shapes to communicate with one another about when it's time to release stress hormones,» Hekman said.

However, Brenner, who together with two others, has just received this year's Nobel Prize in Physiology or Medicine for their discoveries concerning «genetic regulation of organ development and programmed cell death,» maintains that nothing has changed for him.

The research is also the first to demonstrate beneficial effects of UDCA on dopaminergic neurons, the nerve cells affected in Parkinson's disease, in a fly model of Parkinson's disease which carries the same genetic change as some patients with the condition.

Analyzing tissue specimens from 10 people with stomach cancer, the researchers found evidence that those same mature cells in the stomach also had reverted to a stem cell - like state and had begun to change and divide rapidly.

One would culture thin sheets of meat, seeded by cells from a living animal, on a reusable polymer scaffold; the other would grow meat on small edible beads that stretch with changes in temperature.

Biochemist Radhey Gupta of McMaster University in Canada proposes that a bacterium and an archaean fused to form the first eukaryote, based on his analysis of a pair of slow - changing genes found in what may be one of the oldest cells with a nucleus, Giardia lamblia.

They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.

Her most recent paper — this one published in PNAS, the official journal of theNational Academy of Sciences — explains a totally new way that viruses operate in building particles and how viruses can change shapes to interact with their host cells.

Results suggest that while isotretinoin was associated with a change in the average value of some laboratory tests (white blood cell count and hepatic and lipid panels), the average change across a patient group did not meet the criteria for high - risk and the proportion of patients with laboratory abnormalities was low, the authors report.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.

And his group has applied for funding to run lab studies to see if the fish hosting blotchy lesions develop more subtle — and disturbing — symptoms with time, such as a slower swimming speed or changes in blood - cell counts.

When gold nanoparticles combine with red, blue and green glowing proteins, as in this sensor, it's possible to discern drug - induced physical and chemical changes on a cell's surface.

And in related experiments, he made tadpoles grow eyes on their stomachs by changing the electrical properties of cells to mimic those associated with eye formation.

Some may stem directly from how the altered digestive system works — secreting different levels of hormones, for example — or changes in nerve cells that communicate with the gut.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

Researchers also studied the brain tissue of the infected mice under a microscope and found that the memory problems tracked with changes in nerve cells.

The researchers succeeded in changing the DNA of the E coli bacteria in such a way that the substance CB [8](a small molecule of two nanometres in size with a namederived from the resemblance of this molecule with a pumpkin of the family of Cucurbitaceae) attaches to a protein on the cell membrane.

With each pulse, a bit of the excess contents were released and a cyclical breathing - like change in the artificial cell's texture was produced.

The researchers then measured cell composition and electrical activity again and found that the cells dramatically changed when they were in contact with neurons from different regions.

«This paper is a great example of how chemistry can help make step changes in biology,» says Matthew Dalby, a professor of cell engineering at the University of Glasgow and co-senior author on the study with Ulijn.

Instead, the Administration's plans for energy conservation and using energy sources with less CO2 emission will help in the short - term, he said; down the road, a new National Climate Change Technology Initiative will help develop cutting - edge technologies such as fuel cells and carbon dioxide sequestration, Bush said.

The researchers were able to reverse these epigenetic changes with the use of an FDA - approved drug, forcing the cancer cells out of hiding and potentially making them better targets for the same immune therapy that in the past may have failed.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changeIn collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changein skin cells differed among the Esrp knockouts and found hundreds of significant changes.

With the retrograde response, we've changed the amino acid metabolism in a way that allowed the cells to accumulate storage carbohydrates, which stabilize their function,» Friis said.

Changes to the properties of the lipid bilayer component of the cell membrane can alter the function of proteins embedded in the membrane — proteins that regulate critical functions such as transport of materials in and out of the cell and communication with other cells.

Freezing meat damages the cell walls so the mobility of any water molecules and the way in which they interact with the proteins in the sample changes after freezing.

«The brain along with the reproductive system and every other cell in your body is exquisitely sensitive to exceedingly small changes in estrogen and other sex hormones, and the fact that the environment is full of chemicals that can activate estrogen receptors means this phenomenally sensitive system is being perturbed constantly by environmental factors.»

The findings, published Sept. 20 in the Journal of Virology published by the American Society for Microbiology, were publicly revealed almost simultaneously with those from China - based scientists who found a change of a single amino acid made the virus more dangerous to developing brain cells.

Sanford and her colleagues wanted to see whether changes in lipid bilayer properties were reliably correlated with a drug's toxicity to cells, or cytotoxicity.

In fact, there's reason to believe that all of the properties of cell biology that made complex life possible in the next geologic era were put in place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cellIn fact, there's reason to believe that all of the properties of cell biology that made complex life possible in the next geologic era were put in place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cellin the next geologic era were put in place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cellin place here: cytoskeletons that allow eukaryotic cells to change shape, and cell polarity that allows cells to send a molecular message to one side of the cell but not the other, and to interact with nearby cells.

Researchers in Keele University's Research Institute for Science and Technology in Medicine and at the Haywood Rheumatology Centre, in Staffordshire, UK, and the University Hospitals of North Midlands NHS Trust, have for the first time identified disease - associated changes to the DNA epigenome in joint fluid cells from patients with rheumatoid arthritis.