Sentences with phrase «with changes in sequence»

Decision flowcharts guide module selection and sequencing, 16 with a default module sequence suggested, but with changes in the sequence specified to address treatment difficulties.

One way is that it allows you, the designer, to experiment with changes in sequence before you actually start developing the course.

Not exact matches

«But we can say with a fair bit of certainty that all that sequence of changes, starting several years ago, has succeeded in adding more buffering to the system.»

[1:20] How the kindness of a stranger changed Tony's life [3:35] Peter Diamandis talks about the origins of X Prize [6:30] Technology helping the agricultural industry [7:00] Sequencing genomes [8:55] Life - work integration [11:15] Finding your highest calling in life [12:00] Reframing what is «impossible» [14:00] Strategy vs. psychology [15:00] Changing your state [16:00] The science of achievement, the art of fulfillment [19:00] Living in a beautiful state [24:00] Thinking 10x bigger [28:00] Surrounding yourself with a «nothing is impossible» community [29:00] The news pollutes your mind [31:00] Tony's natural gifts and core beliefs [33:30] Overcoming failure and criticism [37:45] Defining your environment [40:00] Life happens for you, not to you [42:00] Rituals and practices to up your game [46:30] Tony's priming process

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

«We have discovered that the two more destructive pathogens share a pattern of parallel changes in their core metabolic pathways that enables them to exploit more efficiently the nutrient resources available in banana,» said Stergiopoulos, who along with bioinformatician Ti - Cheng Chang, led the effort to sequence and analyze the fungal genomes of eumusae leaf spot and yellow sigatoka, comparing their findings with the previously sequenced black sigatoka genome sequence.

With epigenetics we mean such changes in genes that are not determined by changes in the actual DNA sequence, but effects that are superimposed on this, caused for example by environmental effects.

All that changed this month, with the publication of a 400,000 - year - old mitochondrial genome sequenced from the remains of an early human found in a cave in Spain.

In the case of β - ionone, the smell associated with violets, McRae and colleagues managed to pinpoint the exact mutation (a change in the DNA sequence) in the odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note — people who are less good at smelling β - ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasanIn the case of β - ionone, the smell associated with violets, McRae and colleagues managed to pinpoint the exact mutation (a change in the DNA sequence) in the odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note — people who are less good at smelling β - ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasanin the DNA sequence) in the odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note — people who are less good at smelling β - ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasanin the odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note — people who are less good at smelling β - ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasant.

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMIn a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMin nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMin treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMin the September 1 issue of JAMA.

Their trouble with language had been caused by the change of a single nucleotide of DNA — just one letter in the genetic sequence.

«The Neandertal genome sequence just by itself will not tell us what makes humans special, it will always be in conjunction with other work that really addresses the biology of a specific change,» he says.

Many are probably simply the consequence of 6 million years of genetic drift, with little effect on body or behavior, whereas other small changes — perhaps in regulatory, noncoding sequences — may have dramatic consequences.

Small changes in the protein sequence of sodium channels of American compared with German cockroaches leave the latter susceptible to a venom that has little effect on the former.

The team tracked changes in protein sequence that travelled with the disease - causing mutation and were candidates for offering protection.

In brown bears, the sequence of this gene varies from one bear to another, but all the polar bears surveyed have an identical version, with the exact same genetic code at nine variable spots in the gene, about half of which should change the function of the APOB proteiIn brown bears, the sequence of this gene varies from one bear to another, but all the polar bears surveyed have an identical version, with the exact same genetic code at nine variable spots in the gene, about half of which should change the function of the APOB proteiin the gene, about half of which should change the function of the APOB protein.

Biologist Sydney Brenner of the Salk Institute in La Jolla, California, who won a Nobel in 2002 and led the team that did the sequencing, says his next step is to compare it with the human sequence in order to identify regions that have changed little in the 450 million years since the two lineages split.

This altered expression that does not correlate with changes in the base sequence is known as epigenetic regulation (as opposed to genetic regulation).

«Advances in genetic sequencing technologies now allow us to find patterns in large, diverse populations of microorganisms, see how they associate with specific individuals, and understand how they change over time in a way we couldn't just a few years ago,» said Knight, who leads the UC San Diego Microbiome and Microbial Sciences Initiative.

«With more detailed mapping of glaciovolcanic sequences, and the recognition of the importance of these often abrupt changes in depositional environment, our understanding of glaciovolcanic eruptions and the hazards they pose can only be advanced.»

When Pollin and her colleagues sequenced the gene in their Amish volunteers, they found a mutation that matched with those who had lower triglycerides to start with and whose blood levels changed relatively little after drinking the milkshake.

Those inhabiting the human body have received increased attention in recent years, owing to a greater appreciation of the interrelated nature of humans and their microbiome, an improved understanding of microbial ecology, and an unprecedented ability to detect fine - scale microbial community changes with high - throughput sequencing technology (Human Microbiome Project Consortium, 2012).

The ability to create objects that change shape in a controlled sequence over time is enabled by printing multiple materials with different dynamic mechanical properties in prescribed patterns throughout the 3 - D object.

The Genome Sequencing Centers will play a pivotal role in our systematic effort to assess the range of genomic changes associated with malignancy,» said Mark S. Guyer, Ph.D., director of NHGRI's Division of Extramural Research.

While genetics deals with the DNA sequence itself and the heritable changes in the DNA (mutations), epigenetics deals with heritable traits that are not caused by mutations.

She directed policy responses to potential changes in state and federal legislation; coordinated interactions with the Food and Drug Administration; and researched the ethical, legal and social implications (ELSI) of the DNA sequencing of newborn blood spots.

A crucial step in linking sequence variants with changes in phenotype is variant annotation.

We concluded that an expanded Revive & Restore, in partnership with biotech organizations, will be able to offer services that include Genetic Insight (DNA sequencing and analysis), Biobanking (tissue collection and cell culturing), Advanced Reproductive Services (cloning and germ - line transmission), and Genome Engineering (CRISPR, gene - drive, etc.) Applications include restoring genetic diversity, augmenting adaptation to climate change, conferring resistance to disease, and extirpating harmful invasive species.

In addition to variations in chemical composition — both because of the initial abundances and the star's evolutionary status, [34] interaction with a close companion, [35] rapid rotation, [36] or a magnetic field can also change a main sequence star's position slightly on the HR diagram, to name just a few factorIn addition to variations in chemical composition — both because of the initial abundances and the star's evolutionary status, [34] interaction with a close companion, [35] rapid rotation, [36] or a magnetic field can also change a main sequence star's position slightly on the HR diagram, to name just a few factorin chemical composition — both because of the initial abundances and the star's evolutionary status, [34] interaction with a close companion, [35] rapid rotation, [36] or a magnetic field can also change a main sequence star's position slightly on the HR diagram, to name just a few factors.

Using gene sequencing, the researchers learned that every member of the family with congenital heart disease had the same mutation in GATA4 — a change in a single letter in the gene.

The application of transgenesis and other genetic methods - in conjunction with total genome sequence and database information on gene expression patterns, morphological changes during development, and mutant phenotypes - should significantly enhance our ability to unravel the multilayered networks that control gene expression and differentiation.

A few interesting articles in early life human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.

I took these comparative genomic scans to the next level by writing a computer program to identify DNA sequences that are conserved in other animals but have changed rapidly in humans since we evolved from our common ancestor with chimpanzees.

Since the completion of the human genome and beginning with the rise of next - generation sequencing, our community has seen some important changes in how we conduct research.

Molecular evolutionary analysis of the entire coding sequence in the eight representative mammalian species: Monotremes (platypus), Marsupials (opossum) and Eutherians (mouse, rat, dog, rhesus monkey, chimpanzee and human), revealed no excessive non-synonymous nucleotide changes in comparison with synonymous changes.

Those genes that match a sequence with 100 % identity were included in our analyses and their name was changed to that of the cDNA sequence they matched (third column).

Fortunately, experiments done by Dr. Jan Vijg at the Albert Einstein College of Medicine and others on mutations (changes in base sequence in DNA) and additional studies commissioned by SENS Research Foundation on epimutations (changes in the arrangement of methyl groups) suggest that these latter kinds of alterations - the kind that accumulate in cells without triggering apoptosis or senescence or contributing to cancer - accumulate too slowly to make a difference with the current lifespan.

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

From genomic and epigenomic sequences from a subset of the populations, we see changes in methylation patterns between the evolved populations over-represented in some functional categories of genes, which is consistent with some of these differences being adaptive.

Situations like cancer may warrant having a suspected cancer sample characterized, but once a genome is sequenced, only a substantial change in technology with drastically increased resolution would merit another whole genome assay.

Whole genome sequence data of the mutants with altered cell shape, directed mutants, wild type stocks and isolated helical and rod - shaped «wild type» C. jejuni, identified a number of different mutations in pgp1 and pgp2, which result in a change in helical to rod bacterial cell shape.

He trusted her, and she could argue with him; she knew his rhythms, the pace of the long shots, dialogue and action, how to adapt to changes in tone, sequence by sequence.

Zahler takes his time with almost every scene, letting a sequence of O'Dwyer changing the dressing on his injured leg, for example, play out in its painful entirety.

Civil War was also partly filmed with IMAX cameras and the movie in general tends to feel big, visually - speaking, in - between its action sequences and many establishing shots of locations around the globe (as well as the massive title font that's used to identify each individual change in location)- making IMAX the preferable viewing format for Civil War.

The first, by George A. Romero, his wife and assistant director Chris Romero (née Forrest) and Tom Savini, reveals that almost all the cast were friends, family or local Pittsburgh volunteers (even the mall was owned by personal friends of Romero), that the original script had a far bleaker ending (everybody dies) which was changed during the shoot because the film was «too much fun» for it, and that the fourth film, should it ever get made, is a larger - scale affair set in a down - town area, with lots of action sequences and an overarching theme of «ignoring the problem».

In a Q&A with Gary Lockwood (Gary Mitchell of Star Trek) and Keir Dullea, whose work with Otto Preminger caught Kubrick's eye, the two recalled that the posters for 2001 were changed to show Dullea's eye splashed in artificial colors from Trumbull's effects sequence, and the tagline now read, «The Ultimate Trip.&raquIn a Q&A with Gary Lockwood (Gary Mitchell of Star Trek) and Keir Dullea, whose work with Otto Preminger caught Kubrick's eye, the two recalled that the posters for 2001 were changed to show Dullea's eye splashed in artificial colors from Trumbull's effects sequence, and the tagline now read, «The Ultimate Trip.&raquin artificial colors from Trumbull's effects sequence, and the tagline now read, «The Ultimate Trip.»

That's because Deadpool 2's game - changing end - credits sequence includes the Merc with a Mouth using Cable's time - travel device to go back in time and prevent Green Lantern from being made.

Planning the change doesn't need to occupy an entire year, but it should begin with a scope and sequence, and then segue into aligning digital content to replace the static information provided in a textbook.

The education secretary has in her grasp some key levers to head off the perfect storm that is beginning to gather: in seeking information, before the election, about the workload challenges facing schools, she knows that: Ofsted needs extensive reform, possibly replaced with validated peer - to - peer accountability and the incoherent sequencing and pace of curriculum changes need to be rethought with school leaders thinking about what will have a significant impact on children's learning.

The scope and sequence combined with the expertise of the contributors make this volume a vital resource for educators at all levels during a pivotal time of major changes in education policy.