Speaking of trouble, I once read that parents of kids
with childhood leukemia suffer more posttraumatic stress disorders and recurring nightmares than the kids themselves do.
It found that a breastfeeding duration of less than a month was not significantly associated
with childhood leukemia when compared with breastfeeding duration of 6 months or more (OR, 1.2; 95 % CI, 0.9 - 1.6).
Not exact matches
• A high quality case control study in Northern California found that exposure to paternal preconception smoking alone (as well as in combination
with postnatal passive smoking) is highly likely to be important in the risk of
childhood leukemia (Chang et al, 2006).
We found that a history of breastfeeding was associated
with a reduction in the risk of acute otitis media, non-specific gastroenteritis, severe lower respiratory tract infections, atopic dermatitis, asthma (young children), obesity, type 1 and 2 diabetes,
childhood leukemia, sudden infant death syndrome (SIDS), and necrotizing enterocolitis.
Health risks associated
with formula feeding over the long term include increased incidence of infectious morbidity,
childhood obesity, both type 1 and type 2 diabetes,
leukemia, and sudden infant death syndrome (SIDS).
«Health outcomes differ substantially for mothers and infants who formula feed compared to those that breastfeed... For infants, not being breastfed [and being formula fed instead,] is associated
with an increased incidence of infectious morbidity, including otitis media [ear infections], gastroenteritis, and pneumonia, as well as elevated risks of
childhood obesity, type 1 and type 2 diabetes,
leukemia and sudden infant death syndrome (SIDS).»
These studies are at risk for selection bias both of cases and of control individuals and their results might be influenced by potential confounders such as other health behaviors that may be independently associated both
with breastfeeding and
childhood leukemia risk, although this is of course not limited to case - control studies.
With the exception of otitis media and childhood leukemia, each of these conditions has a documented black / white health disparity, with higher rates observed among black (vs. white) children (16 —
With the exception of otitis media and
childhood leukemia, each of these conditions has a documented black / white health disparity,
with higher rates observed among black (vs. white) children (16 —
with higher rates observed among black (vs. white) children (16 — 23).
A separate meta - analysis of 15 studies indicated that ever breastfed compared
with never breastfed was associated
with a 9 % lower risk for
childhood leukemia (odds ratio, 0.91; 95 % CI, 0.80 - 1.04), although the definition of never breastfed differed between studies.
Twelve studies, contributing 7596
childhood leukemia cases, were included in the analysis of breastfeeding and
childhood leukemia and the authors found a moderate effect of between - study heterogeneity that was eliminated when they removed the study by Smulevich et al. 17 The calculated pooled OR of the 12 studies indicated a statistically significant inverse association between ever breastfed compared
with never breastfed and
childhood leukemia (OR, 0.87; 95 % CI, 0.77 - 0.99).
Because there are discernable differences in
childhood leukemia rates and breastfeeding rates between developed countries
with a Western lifestyle and other countries, an analysis was conducted including only the 12 studies18 - 25,37,38,40,42 led in developed countries.
In this meta - analysis of published (1995 - 2011) case - control studies examining the relationship between breastfeeding and
childhood leukemia, all analyses, except the subanalysis for AML alone, which was not statistically significant, showed that being breastfed for at least 6 months compared
with less than that or not at all was significantly associated
with a 14 % to 20 % lower risk for
childhood leukemia,
with a 20 % lower risk when all selected 17 studies were included in the analysis.
The UK
Childhood Cancer Study investigators23 published in 2001 a study that provided 1636
leukemia cases and indicated a weak evidence of borderline statistical significance that ever (compared
with never) having been breastfed was associated
with a small reduction in
leukemia risk (OR, 0.89; 95 % CI, 0.84 - 1.00).
The separate analysis of these 4 studies indicated a statistically significant inverse association between any breastfeeding for 6 months or more compared
with a shorter duration and
childhood leukemia (OR, 0.84; 95 % CI, 0.75 - 0.94).
This analysis including 7 studies20,23,25,37 - 39, 42 showed that any breastfeeding for more than 6 months compared
with a shorter duration was associated
with a 17 % decreased risk for
childhood leukemia (OR, 0.83; 95 % CI, 0.72 - 0.96).
Ever breastfeeding compared
with never breastfeeding is associated
with a 9 % lower risk for
childhood leukemia (odds ratio, 0.91; 95 % CI, 0.80 - 1.04).
61 The distinction between exclusive breastfeeding and partial breastfeeding in the analyses of the association between breastfeeding and the risk for
childhood leukemia is essential given that the addition of infant formula, together
with breast milk or instead of it, changes the infant's gut microbiota, affecting the immunology of the infant.62, 63 Thus, misclassification might weaken the association between breastfeeding and lower risk for
childhood leukemia.
One of those early patients was a young girl named Emily Whitehead who arrived in June's clinic, «on death's door,»
with an aggressive form of relapsed
childhood leukemia.
Summers and the research team, led by Dr. Mike Jensen at the Ben Towne Center for
Childhood Cancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02 trial, approximately 40 percent of them relapsed
with a
leukemia that evolved to circumvent the CAR T cells that were reprogrammed to detect and destroy cancer.
There's growing concern among researchers that public wariness about the newborn screening program will create a backlash —
with parents declining to screen their kids (who may end up much sicker because their disease wasn't caught early), and
with the spots no longer made available for valuable pediatrics research, such as tracing the origins of
childhood leukemia.
«High exposure to benzene during pregnancy is associated
with low birth weight, an increased risk of
childhood leukemia and a greater incidence of birth defects such as spina bifida,» said Caron - Beaudoin.
Most
childhood leukemias have very high remission rates,
with some up to 90 % (remission means there is no longer evidence of cancer cells in the body).
Prevalence and characteristics of metabolic syndrome in adults from the French
childhood leukemia survivors» cohort: a comparison
with controls from the French population
That evidence, combined
with the present study, suggests that
childhood leukemia may regularly be initiated before birth,» said Wiemels.
The researchers conducted their study by using a highly sensitive probe to scrutinize minute numbers of
leukemia cells in blood samples previously collected from newborns who during
childhood were diagnosed
with leukemia.
«The use of 15 - mg / kg ATLG was associated
with statistically improved event - free survival in the subgroups of children
with acute
leukemia or
with acute lymphoblastic
leukemia, which represents the more frequent indication for an allograft in hematologic malignancies of
childhood.»
In addition, we have access to new agent trials through the Therapeutic Advances in
Childhood Leukemia and Lymphoma (TACL) consortium, and we offer CAR T - cell therapy for eligible children with relapsed or refractory acute lymphoblastic leukemi
Leukemia and Lymphoma (TACL) consortium, and we offer CAR T - cell therapy for eligible children
with relapsed or refractory acute lymphoblastic
leukemialeukemia (ALL).
We know cured meat increases cancer risk —
childhood leukemia, for example — yet, higher intake of vegetables is associated
with a reduced risk.
The pilot study observed children who have been diagnosed
with acute lymphoblastic
leukemia — the most commonly diagnosed
childhood cancer.
The patient population for the pilot will be children aged 3 through 11 years who are newly diagnosed
with acute lymphoblastic
leukemia — the most commonly - diagnosed
childhood cancer — or who have been in treatment for less than 12 months.
The EPHX1 rs1051740 Polymorphism Is Associated
with Childhood Acute Lymphoblastic
Leukemia in a Korean Population