Soluble fiber can reduce both «bad» LDL and overall cholesterol, perhaps by binding
with cholesterol particles in your digestive system and moving them out of the body before they're absorbed.
Not exact matches
After secretion, apolipoprotein E and
cholesterol associate
with high - density lipoprotein to form a
particle that can deliver
cholesterol to the liver by receptor - mediated endocytosis.
To mimic this versatile substance, Joke Bouwstra and Robert Rissman at Leiden University in the Netherlands mixed a range of fatty compounds including lanolin, fatty acids, ceramides and
cholesterol with particles made of a water - storing hydrogel (International Journal of Pharmaceutics, DOI: 10.1016 / j.ijpharm.2009.01.013).
In individuals
with high HDL -
cholesterol levels in the circulation, the lipid composition of the HDL
particle was more beneficial regarding heart disease risk.
Men are also reported to have smaller low - density lipoprotein
particles than women, whereas men and postmenopausal women have higher levels of serum
cholesterol and triglyceride sub-classes compared
with premenopausal women.
In the blood, fats and
cholesterol are packaged,
with key protein components, into
particles called lipoproteins.
The LDL -
particle number and the small dense LDL -
particles fell toward normal
with the addition of the avocado to the diet — both favorable results for people
with high
cholesterol.
It also transports
cholesterol from extra-hepatic sites, including the arterial wall, to the liver for excretion via reverse
cholesterol transport.77 Results from IER (60 - 85 % ER / alternate days) trials have thus far been inconsistent,
with some reporting decreases 40, and others increases 37, 39, but
with the majority showing no effects on HDL
cholesterol levels.38, 42, 43, 45, 49, 51, 52Inconsistencies may have arisen due to the biphasic response of HDL documented by studies of ER induced weight - loss, whereby levels typically decrease during active weight - loss then either return to baseline or (less commonly) rise following attainment of weight stability.78 Complementary increases in HDL levels and
particle size have been shown when endurance exercise have been combined
with IER 42, 46, 47 however further discussion goes beyond the scope of this review.
Increased enterohepatic circulation on high fat means that
cholesterol is kept «in play» - bounced back into the bloodstream in ApoB
particles - while low enterohepatic circulation, in people
with with higher synthesis rates, during weight loss - when
cholesterol is being dumped by shrinking cells - means that
cholesterol can pile up in the gall bladder faster than it can be conjugated to bile salts and bile acids and faster than it can be extracted by the weak stimulus of low fat food.
In a 2010 study published in the American Journal of Clinical Nutrition, the researchers found that when you replace saturated fat
with a higher carbohydrate intake, you increase insulin resistance and obesity, and increase your chances of getting heart disease by increasing triglycerides and small LDL
particles, and reducing beneficial HDL
cholesterol.
It is important to understand that cardiovascular disease is not just an illnesses that is associated
with having high blood fats (high LDL
cholesterol and an abnormal distribution of LDL
particle size), but it is also an inflammatory condition.
«The results indicate that when the
cholesterol and
particle measures of LDL disagree, the clinical and subclinical outcomes track
with LDL - P more so than
with LDL - C» http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070150/
What matters is whether the
cholesterol and fat residing in those LDL particles have been oxidized... «Cholesterol has nothing to do with heart disease, except if it's oxidized,» Dr. Kummerow said... [He] contends that the high temperatures used in commercial frying cause inherently unstable polyunsaturated oils to oxidize, and that these oxidized fatty acids become a destructive part of LDL
cholesterol and fat residing in those LDL
particles have been oxidized... «
Cholesterol has nothing to do with heart disease, except if it's oxidized,» Dr. Kummerow said... [He] contends that the high temperatures used in commercial frying cause inherently unstable polyunsaturated oils to oxidize, and that these oxidized fatty acids become a destructive part of LDL
Cholesterol has nothing to do
with heart disease, except if it's oxidized,» Dr. Kummerow said... [He] contends that the high temperatures used in commercial frying cause inherently unstable polyunsaturated oils to oxidize, and that these oxidized fatty acids become a destructive part of LDL
particles.
What I'm curious about is whether you've noticed your weight and
cholesterol LDL - P (
particle count) levels going up
with your new, veggie - heavy, diet or if things have stayed the same.
According to research found in Atherosclerosis, Thrombosis, and Vascular Biology, large LDL
particles were not found to be associated
with an increased risk of ischemic heart disease in men, and that the cardiovascular risk LDL
cholesterol does pose is related to levels of its small
particles.
The results from this trial clearly indicate that the replacement of refined carbohydrates
with EPRO and UFA increased insulin sensitivity, LDL peak
particle size, and lowered fasting TG and VLDL
cholesterol concentrations in men and women
with an elevated TG concentrations.
The results of this study also show that theEPRO / UFA condition reduced TD and VLDL
cholesterol concentrations and increased LDL
particle size compared
with the refined - carbohydrate condition, indicating improved cardiovascular health.
Lipoprotein lipid profile disturbances associated
with an elevated TG level include low High Density Lipoprotein (HDL)
cholesterol and HDL
particle (HDL - P), and a predominance of small dense Low Density Lipoprotein (LDL) and LDL
particle (LDL - P).
Moreover, all LDL
cholesterol is not harmful — only tiny LDL
particles, which increase in those
with carbohydrate resistance.
Not only does it help
with cholesterol but L. reuteri 30242 has been shown to safely support healthy CRP (a marker for inflammation), fibrinogen (involved in clot formation), apoB - 100 (a marker for LDL
particle size, a known cardiovascular risk factor), and vitamin D levels (important for cardiovascular health) for those within normal range.3, 4,5
For a large proportion of the population, however, the effect of higher - carbohydrate diets, particularly those enriched in refined carbohydrates, coupled
with the rising incidence of overweight and obesity, creates a metabolic state that can favor a worsening of the atherogenic dyslipidemia that is characterized by elevated triglycerides, reduced HDL
cholesterol, and increased concentrations of small, dense LDL
particles (6, 7).
In contrast, the higher saturated fat intake raised concentrations of larger, more
cholesterol - enriched LDL
particles, thus offsetting the reduction in total LDL concentrations that was observed
with lower saturated fat intake (8)(Figure 1).
Studies of atherogenic lipoprotein concentrations and properties have raised questions about the benefit of lowering saturated fat intakes by increasing carbohydrate intake, which can induce atherogenic dyslipidemia, and the benefit of increasing monounsaturated fat intakes, which does not lead to improvements in the properties of LDL
particles that are associated
with atherosclerosis in animal models, although substitution
with monounsaturated fat rather than carbohydrate has been shown to reduce the ratio of total and LDL
cholesterol to HDL
cholesterol.