Sentences with phrase «with chronic phase»

Ponatinib Extends Survival Over Transplant in Chronic Phase CML: The results of a new study that included patients from the PACE trial and the European Bone Marrow Transplant registry revealed that treatment with ponatinib yielded better overall survival (OS) compared with allogeneic stem cell transplantation (allo - SCT) in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I mutation.

«Although TKIs such as the first - generation TKI imatinib mesylate (IM) and the second - generation TKIs dasatinib and nilotinib have markedly improved the prognosis of patients with chronic phase CML, a cure remains elusive.

Not exact matches

Reldesemtiv is the subject of three ongoing Phase 2 clinical trials enrolling patients with spinal muscular atrophy, chronic obstructive pulmonary disease and amyotrophic lateral sclerosis.

Urging clergy and men of religion to renew or revive the practice of prayer, particularly meditation; (2) Distinguishing between the use of alcohol which does not produce a chronic alcoholic and that in which there is «the allergic nature of true alcoholism»; (3) Stressing that «elimination of the phenomenon of craving that follows the treatment does not constitute a cure [but that] the final cure rests with themselves [alcoholics in the second phase of alcoholism]»; (4) Advocating «moral psychology» in achieving entire recovery from alcoholism; (5) Describing the success of the AA.

I agree with Dr. Wiessbluth when he says that children who are out of phase behave as if they have chronic jet lag syndrome.

Narratives range from humorous to heart - wrenching: a teen is smitten by an older boy, a son battles drug addiction, a parent steals the unthinkable, a daughter and her family navigate thunderstorms, a mother redefines «home» for her autistic son — plus compelling essays on parenting teens with chronic illness or anxiety disorders or that inevitable phase of parenting which requires letting go of your teenager.

Results from three Phase III clinical trials (ION - 1, ION - 2 and ION - 3) evaluating the investigational once - daily fixed - dose combination of the nucleotide analogue polymerase inhibitor sofosbuvir (SOF) 400 mg and the NS5A inhibitor ledipasvir (LDV) 90 mg, with and without ribavirin (RBV), for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection have been presented at the International Liver CongressTM 2014.

It is believed that chronic wounds get stuck in an inflammatory phase, with a low - oxygen microenvironment and the persistent presence of enzymes that break down tissue proteins.

With approximately two - thirds of responders to AF - 219 treatment showing more than a 50 % reduction in cough frequency, we plan to advance the development of AF - 219 by initiating a Phase 2b study in patients with chronic cough early next year and to initiate other studies in preparation for registration studies.&raWith approximately two - thirds of responders to AF - 219 treatment showing more than a 50 % reduction in cough frequency, we plan to advance the development of AF - 219 by initiating a Phase 2b study in patients with chronic cough early next year and to initiate other studies in preparation for registration studies.&rawith chronic cough early next year and to initiate other studies in preparation for registration studies.»

Afferent Pharmaceuticals today announced publication of results from a Phase 2 clinical trial demonstrating that the company's novel drug candidate, AF - 219, reduced daytime cough frequency by 75 % compared to placebo in patients with treatment - refractory chronic cough.

In collaboration with various rehabilitation clinics, the RUB researchers have tested the feasibility of passive stimulation as a therapeutic option: about 50 patients were treated after a stroke (sub-acute phase) and several chronic patients were treated long - term over many months.

This Phase 3 randomized, double - blind study included 763 adults with chronic HCV genotype 1 infection, a form of the virus found in up to 75 percent of infections, and compensated liver diseases, who had previously not responded or only partially responded to at least one course of peginterferon and ribavirin.

They assessed gene activity at time points known to correspond with key phases of disease: the «induction phase,» the time before the peak level of photoreceptor cell death; the «execution phase,» when the highest rates of photoreceptor cell death occur; and the «chronic phase,» during which photoreceptor cell death continues at somewhat reduced levels.

A Phase III Randomized Open - Label Multi-Center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid - Refractory Chronic Graft vs Host Disease after Allogenic Stem Cell Transplantation (REACH 3)

«Our research suggests that what starts ALS and what keeps it going are two separate phases; it also suggests that with the right therapy, ALS could become a manageable, chronic disease.»

Allogeneic Sibling Donor Peripheral Blood Stem Cells Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia in Blast Crisis - Successful Treatment Despite Severe Phase of the Disease

As anticipated, mice infected with Type II parasites succumbed to infection during both the acute and chronic phase.

Patients with chronic myeloid leukemia in the blast phase pose a significant therapeutic challenge and have poor survival, even in the tyrosine kinase inhibitor era, according to a new study.

Her interests in the laboratory included strategies to eradicate HIV - 1, with a focus on the HIV - 1 reservoir in HAART - treated patients from acute or chronic phase infection.

A phase I study of dasatinib in children and adolescents with chronic myeloid leukemia (CML) and other malignancies determined dosing for further studies and suggested the drug is well tolerated and effective in these patients.

Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic squamous cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).

The moment you are diagnosed with a chronic illness, you go through the phases of grief.

Designed for individuals with an altered urinary pH level and suffering from (CFS) chronic fatigue syndrome or fibromyalgia, Metagenics UltraClear PLUS pH contains added nutrients to promote an alkaline urinary pH status and support Phase II activity.

Deficiency of «phase II» nutrients is a common finding with most chronic conditions.

A few Refs: http://labtestsonline.org/understanding/analytes/ferritin/tab/test «Ferritin is an acute phase reactant and thus may be increased in people with inflammation, liver disease, chronic infection, autoimmune disorders, and some types of cancer»

The Baltimore Early Phase Unit is currently seeking volunteers with chronic plaque psoriasis to p. Screening and outpatient study dates are flexible.

Acute conditions usually subside quickly, typically within one phase of treatments, while chronic conditions can be controlled with regular treatments.

Dogs that are in the chronic phase with a weakened immune system have a poor prognosis and a lower rate of survival.

In Ontario for example, K. Wing, a chronic care facility operated by the Sunnybrook Medical Centre under terms of an agreement with the Department of Veterans Affairs («DVA»), was phasing out male orderlies and replacing them with nursing assistants, the vast majority of whom were female.

The first phase involved consultation with Aboriginal people with chronic illness and experiencing depression, anxiety or a related disorder (the client group), and with service providers who assisted the client group.

I have worked with a wide variety of clientele including school - aged children, adults with serious mental illness (Bipolar Disorder, Psychosis), substance abusers, military personnel (both active duty and retired), and other adults who are struggling with depression, anxiety, chronic pain, trauma, marital distress, and phase of life / adjustment problems.