Sentences with phrase «with cisplatin»

Dogs have often been treated with cisplatin by injecting the fluid right into the affected body cavity (intracavitary treatment).

This drug is indicated in combination with Cisplatin (a chemotherapeutic drug) for the first - line treatment of patients with inoperable, locally advanced, or metastatic non-small cell lung cancer.

In combination with cisplatin, niclosamide inhibited epithelial - mesenchymal transition (EMT) and tumor growth in triple - negative breast cancer [34].

Combined niclosamide with cisplatin inhibits epithelial - mesenchymal transition and tumor growth in cisplatin - resistant triple - negative breast cancer.

«Given that pemetrexed combined with cisplatin may be less toxic than and as active as cisplatin plus paclitaxel and that it can be combined with bevacizumab, investigating the comparison of cisplatin - pemetrexed plus bevacizumab with cisplatin - paclitaxel plus bevacizumab would be the next appropriate step,» said Dr. Miller, who holds the Amy and Vernon E. Faulconer Distinguished Chair in Medical Science and the Dallas Foundation Chair in Gynecologic Oncology.

«We found that pemetrexed combined with cisplatin is less toxic, well tolerated, and should be developed for further treatment of cervical cancer,» said gynecologic oncology specialist Dr. David Miller, Professor of Obstetrics and Gynecology and a member of the Harold C. Simmons Cancer Center.

Ovarian cancer is typically treated with cisplatin, a platinum - based chemotherapy.

As a result, the researchers then engineered a second nanostructure which was suffused with cisplatin.

Not exact matches

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

Compared with a normal mouse cochlea (top), cisplatin exposure reduces the number of outer hair cells (middle).

Patients with epidermal growth factor receptor (EGFR) expressing advanced squamous non-small-cell lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis from the SQUIRE trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland.

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin.

The multicentre trial included 153 patients with surgically - treatable malignant pleural mesothelioma, who were first treated with three chemotherapy cycles of cisplatin and pemetrexed, followed by surgical removal of affected lung tissue, with the goal of complete removal of the cancerous areas of lung.

They found that adaptive immunity is reversely associated with resistance of cisplatin, the drug used for ovarian cancer.

Twelve days later they injected the animals with either IP5 or cisplatin, a common ovarian cancer treatment.

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors

In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.

Aerosol administration was performed as follows, the residual cup was filled with 8mls of the cisplatin agent and the nebulisation time was 10 minutes (almost 1 ml / minute) as observed from our previous studies.14 The aerosol was delivered to the mice (one by one) within a nose only cage that has been previously presented.34 In the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulated.

The results indicate that the aerosol cisplatin group had a long term survival with the intratumoral cisplatin group following.

indicate that there was high concentration of the cisplatin within the tumor with the intratumoral method of administration when compared with the two aerosol methods at the same time.

Previous published data with aerosol cisplatin indicated that the Maxineb ® (6 liters / minute and 35 psi) with a large residual cup (≤ 10mls) produced 1.266 μm.14 (Figure 2).

Furthermore, with both methods of administration the cisplatin was diffused throughout the body of the mice.

Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity.

Short Research Communication The Factors Reducing Relative Dose Intensity of Cisplatin and Vinorelbine as Adjuvant Chemotherapy in Patients with Non-Small Cell Lung Cancer Ryo Inose, Katsuyuki Takahashi, Naruo Yoshimura, Tomoya Kawaguchi, Mitsutaka Takada, Katsuya Nagayama Oncomedicine 2018; 3: 9 - 14.

The only randomized study of adjuvant chemotherapy in mucosal melanoma demonstrated significantly increased relapse - free and overall survival in patients receiving temozolomide and cisplatin, as compared with interferon alfa - 2b or observation.

RNA - sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel.

Correlative nanomechanical profiling with super-resolution F - actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells Sharma S, Santiskulvong C, Bentolila, L A, Rao J, Dorigo O and Gimzewski J K 2012 Nanomedicine: Nanotechnology, Biology, and Medicine 8 757 - 766

All patients underwent induction therapy with four cycles of pemetrexed and cisplatin, and then the pemetrexed arm received pemetrexed continuation maintenance therapy until disease progression while the placebo arm received best supportive care.

Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on - chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions.

Cisplatin is a common chemo drug, normally used with an IV in our canine cancer patients.

Indications for cisplatin beads include tumors removed with «thin margins» such as:

Dogs that were only treated with chemotherapy (Cisplatin) survived for a median of 202 days.

Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs.

The median survival in dogs treated with early chemotherapy alone (cisplatin or carboplatin) at Purdue University was 130 days.

Implantable cisplatin chemotherapy has been used to treat dogs with osteosarcoma with encouraging results.

CISPLATIN (Platinol) Nausea and vomiting — usually only seen during administration of the drug or within first 24 - 48 hours, often controlled with medication.

The chemotherapeutic agents typically used for Greyhounds with OSA are cisplatin, carboplatin, or doxorubin.

Sixteen dogs with histologically confirmed appendicular osteosarcoma were treated by amputation followed by cisplatin and doxorubicin chemotherapy.

Cisplatin was administered at 50 mg / m2 intravenously (IV) concurrent with saline - induced diuresis.