Ten of the 15 vaccinated dogs (66.7 %) in Group 2 that relapsed were treated
with cyclophosphamide, vincristine, and prednisone (COP) as salvage therapy and four of these dogs (40 %) achieved durable second clinical remission (> 22 months) and did not relapse.
Timed sequential treatment
with cyclophosphamide, doxorubicin, and an allogeneic granulocyte - macrophage colony - stimulating factor - secreting breast tumor vaccine: a chemotherapy dose - ranging study of safety and immune activation.
Not exact matches
Luznik and his team inventoried types of immune cells present in the blood of bone marrow transplant patients treated
with post-transplant
cyclophosphamide.
They found high levels of the regulatory T - cells in patients treated
with post-transplant
cyclophosphamide, and lab - cultured cells survived
cyclophosphamide treatment.
Luznik says that the researchers» next step will be to test the short course therapy in a phase III randomized clinical trial that would directly compare results in patients who receive the
cyclophosphamide treatment
with those who receive either a separate, experimental approach to prevent GVHD or the more traditional six - month immunosuppressive therapy.
In this study, patients began treatment
with chemotherapy using
cyclophosphamide and topotecan and the experimental monoclonal antibody hu14.18 K322A.
Among 10 women
with advanced ovarian cancer who got injections of the personalized vaccine once every three weeks —
with the medications
cyclophosphamide and bevacizumab (marketed as Avastin)-- eight showed a strong immune response and were still alive after two years.
3) The infusion time of MTX was reduced from 24 h to 3 h as a higher drug penetration has been achieved by a shorter infusion time.9 4) Importantly, given the cited literature, the treatment was age - adjusted
with patients aged over 65 years having
cyclophosphamide of the second and fifth and ifosfamide of the fourth chemotherapy cycle replaced by the less toxic agent temozolomide (TZM).
The patient was treated on an acute lymphoblastic leukemia (ALL) protocol for eight cycles of hyperCVAD (
cyclophosphamide, vincristine, adriamycin and decadron) alternating
with MTX / Ara - C (methotrexate and cytarabine) and achieved complete remission (CR) confirmed by a bone marrow biopsy and by the resolution of most of her skin lesions.
The combination of intermediate - dose
cyclophosphamide (ID - CTX) and granulocyte colony - stimulating factor (G - CSF) fails to mobilize peripheral blood stem cells (PBSCs) in approximately 20 % of treated patients
with multiple myeloma (MM).
Based on the results of this study the standard treatment for DLBCL
with R - CHOP (rituximab,
cyclophosphamide, vincristine, doxorubicin, and prednisone) should be given as standard treatment.
The trick
with subtractive immunization is to first tolerize an organism -
with a non-metastatic tumor cell, using an immune suppressant chemical like
cyclophosphamide to kill off all the immune cells that recognize the immunodominant antigens.
Is post-transplant
cyclophosphamide — based haploidentical donor transplantation appropriate for racial and ethnic minority patients
with hematologic cancers?
Dr. Lewis has been Dartmouth PI on a first in man study of the combination of
cyclophosphamide pretreatment
with a humanized immunoconjugate of an anti-EpCAM antibody linked to two molecules of IL - 2.
This study established the MTD of the
cyclophosphamide - huKS - IL2 combination (mainly limited by IL - 2 side effects), the pharmacokinetics of huKS - IL2 and its systemic immunologic and immunogenic effects in patients
with solid tumors (BMC Cancer.
Consuming kefir everyday for 4 months my rbc is raised 5 whole units (from 20 to 25 and still going, even three lines of treatments mtx, cyclosporine,
cyclophosphamide didn't achive anything close to that), feel much better, sleep better, no infections (that's a big deal in my condition), my visits to WC regulised; 2 everyday, no stress, no gum desease (leukemias cause severe gum problems), no bad breath, my skin looks healthy, my pale colour dissapeared, i even go to gym 3 - 4 days per week and
with goji berries these 2 working miracles on me.
As
with all prescribed medicines,
cyclophosphamide should only be given to the pet for which it was prescribed.
Yes, but possible interactions may occur
with aminoglycosides, amoxicillin, clindamycin,
cyclophosphamide, erythromycin, lincomycin, penicillins, phenobarbital, phenytoin, primidone, rifampin, streptomycin and tylosin.
Giving
cyclophosphamide with food may reduce GI upset.
Yes, but possible interactions may occur
with amitriptyline, beta - blockers, clomipramine,
cyclophosphamide, digoxin, metoprolol, modified live vaccines, omeprazole, propanolol, theophylline and warfarin If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.
Yes, but possible interactions may occur
with anticholinesterase agents, amphotericin B, cyclosporine,
cyclophosphamide, digitalis glycosides, erythromycin, furosemide, insulin, mitotane, NSAIDS (aspirin, carprofen, deracoxib, etc.), phenobarbital, phenytoin, rifampin and some vaccines.
One study shows that the 2 - year survival rate for8 dogs treated
with surgery alone was 29 % while the survival rate for 8 dogs treated
with the chemotherapy medications adjuvant 5 - fluouracil and
cyclophosphamide was 100 %.3