Sentences with phrase «with cytokine production»

Psychological well - being ratings have also been positively associated with cytokine production after vaccination for influenza and hepatitis (21).

In addition, WEHI - 435 (N -(2 -(4 - amino - 3 -(p - tolyl)-1 H - pyrazolo [3,4 - d] pyrimidin -1-yl)-2-methylpropyl) isonicotinamide) interfered with cytokine production in vitro and in vivo and ameliorated experimental autoimmune encephalomyelitis in mice (Nachbur et al., 2015).

Not exact matches

The researchers found that having higher amounts of penile anaerobes was associated with higher production of biochemicals, called cytokines, capable of recruiting immune cells.

When cells that produced IL - 21 were put in culture with synovial fibroblasts (which are the main contributors to joint inflammation in rheumatoid arthritis), they induced the production of proinflammatory cytokines by these synovial fibroblasts, and cells that do not produce IL - 21, did not demonstrate this same outcome.

Along with steroids, the mainstay of GVHD treatment today is drugs that turn down the production of IL - 2, a cytokine that helps T cell populations expand and diversify.

Production of the cytokine IL - 22 deceases with age, reducing the immune system's defence against the Borrelia bacteria.

We show that inoculation of mice with DENV NS1 alone induces both vascular leakage and production of key inflammatory cytokines.

Enhanced disease is associated with altered cytokine production and T cell proliferation.

Different profile of cytokine production in patients with systemic sclerosis and association with clinical manifestations

As a person ages, the immune response to antigenic stimulation with the influenza virus shifts toward T helper type 2 cytokine production.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

Chloroquine Prevention Of Murine MHC Disparate Acute Graft - Versus - Host Disease Correlates With Inhibition Of Spleenic Response To CpG Oligodeoxynucleotides And Alterations In T Cell Cytokine Production, Biol Blood Marrow Transplant 8 (12): 648 - 55, 2002.

Furthermore, fasting increases the production of the anti-inflammatory kind of cytokines, which are associated with improved insulin sensitivity, decreased fat storage and improved muscle regeneration.

That being said, the production of pro-inflammatory cytokines is associated with insulin resistance, obesity and metabolic syndrome, whereas a higher production of anti-inflammatory cytokines has been shown to improve insulin sensitivity (which helps protect the organism from developing diabetes and cardiovascular diseases), decrease fat storage, enhance muscle regeneration and support longevity.

And according to recent studies conducted in Japan, the full ripe bananas with dark patches on their skin produce the largest quantity of TNF (Tumor Necrosis Factor), a cytokine that fights abnormal tumor cells in the body by stimulating the production of white blood cells and assisting their communication.

• Effects of soy isoflavones on the make - up of the gut microflora • Bacterial transformation of genetically modified soy DNA into gut bacteria capable of expressing toxic proteins that damage the intestinal lining • Effects of chemical contamination from glyphosate residues on neurological and gut function • Soy - induced activation of the immune system and altered production of inflammatory cytokines associated with febrile seizures

It boosts the production of cytokines, which are small proteins that work with cells to help regulate immune responses and strengthen cell membranes.

The detrimental effects of omega - 6s are articulated by Fernandes and Venkatraman (1993), with, «The increased consumption of many vegetable oils particularly of the n - 6 series is... viewed as pro-inflammatory and is suspected as one of the possible causes for the rise in certain malignant tumors, rheumatoid arthritis and autoimmune diseases primarily due to the increased production of pro-inflammatory cytokines» (p. S19).

«Storing excess fat around the organs increases production of pro-inflammatory chemicals, also called cytokines, which leads to inflammation; at the same time, it interferes with hormones that regulate appetite, weight, mood and brain function.»

Individuals with higher omega 6 levels had more inflammatory cytokines in the skin tissue, a weakened epidermal barrier and increased sebum production.

The high antioxidant content of blueberries contributes many health benefits, such as boosting the production of cytokines, which are small proteins that interact with other cells and help regulate immune responses, promote anti-inflammatory activity, and strengthen cell membranes, among other important functions.

The deranged biochemistry and tissue injury associated with these conditions stimulates ongoing production of inflammatory proteins and cytokines, chemical messengers that initiate and prolong the inflammatory response, creating a vicious cycle of chronic inflammation that may have devastating effects on patient quality of life.

In addition, it stimulates the production of «cytokine» which are involved with the immune system.

Researchers found that HA inhibited inflammatory cytokine activity in mice with inflamed joints.18 A similar study reviewed the effects of HA on acute and chronic inflammation in rats, finding HA suppressed inflammatory reactions to aid healthy cartilage production.19

Pure Encapsulations Arabinogalactan has demonstrated the ability to activate immune cells involved with the body's first line of defense and to promote cytokine production.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Consistent with other investigators, 22,58 there were not reliable relationships between the local production of cytokines at inflammatory sites and levels in systemic circulation (data not shown); thus, local production is the primary presumptive pathway.22, 58

Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31

However, consistent with the differences between visits in wound healing, production of IL - 6, IL - 1β, and TNF - α increased more steeply between 4 and 22 hours following the social support interaction than after the conflict interaction, ending up higher at 22 hours at the first visit for all 3 cytokines (IL - 6, F2, 81 = 3.55; P =.03; IL - 1β, F2, 81 = 9.12; P <.001; TNF - α, F2, 81 = 3.56; P =.03).

We expected that higher levels of hostile marital behavior would be associated with slower healing of wounds, lower production of proinflammatory cytokines in blister chamber fluid, and higher cytokine production in peripheral blood; however, short - term marital strife would magnify these relationships such that more hostile couples would show relatively greater deficits on these dimensions relative to low - hostile couples during and following the conflict visit.

In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging.

Prior work with the blister - chamber model showed that even modest levels of stress prior to wounding were reflected in lower production of proinflammatory cytokines at the wound site.21 Thus, the fact that the social support interaction always occurred at the first GCRC admission and yet wound healing and local IL - 6, TNF - α, and IL - 1β production were all poorer following conflict suggests that the effects of the disagreement were larger than our data suggest.