Sentences with phrase «with cytotoxic»

We must be very careful when dealing with cytotoxic agents, but they can be very useful when handled and delivered appropriately.

Favorable responses with minimal toxicities in monotherapy trials have led to the first melanoma studies of T - VEC in combination with the cytotoxic T - lymphocyte — associated antigen 4 inhibitor ipilimumab and, separately, with the programmed death 1 — blocking antibody pembrolizumab.

Receptor - targeted therapy of human experimental urinary bladder cancers with cytotoxic LH - RH analog AN152 [AEZS - 108].

We recently developed a mouse strain, which can be easily reconstituted without previous conditioning (irradiation or treatment with cytotoxic drugs) and we therewith defined all parameters involved in successful HSC transplantation.

Poliovirus - specific CD4 + Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

Not exact matches

Most medications are safe in breastfeeding, with rare exceptions such as cytotoxic chemotherapy drugs.

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

In healthy skin, CD49a + and CD49a cells are dormant, but quickly respond with inflammatory and cytotoxic effects when stimulated by IL - 15, a protein secreted from skin cells as a rapid - response defence against microbial attack.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

The CNIC research team generated cytotoxic memory T cells specifically targeting cancer by using different methods for vaccination with tumor antigens.

In the sensitive tumor models, the ability of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.

Daniel E. Speiser and coworkers demonstrate that human cancer - specific cytotoxic CD8 T cells are strongly activated after vaccination with peptides and CpG oligonucleotides, representing the currently most powerful synthetic cancer vaccine formulation.

Here we show that MAIT cells display cytotoxic activity towards MR1 overexpressing non-hematopoietic cells cocultured with bacteria.

Subjects who have any previous treatment with DNA - damaging cytotoxic chemotherapy (prior taxane chemotherapy allowed).

New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.

Therefore, to overcome chemoresistance mediated by EMT, drug screening efforts have focused on eliminating the mesenchymal subpopulation by searching for drugs with preferential cytotoxic effects on mesenchymal, rather than epithelial HMLE subpopulations [7].

We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB / c WEHI mice infected at birth with LCMV Armstrong strain.

Hartl's research focuses on understanding the role of molecular chaperones in protein folding and in neurodegenerative disorders such as Huntington's or Parkinson's disease, which are associated with protein misfolding and cytotoxic aggregation.

Furthermore, they may be cytotoxic or may instead exert an anticancer effect by acting on one or more aspects of the tumor microenvironment either alone or in combination with existing anticancer treatments [3, 4].

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency.

Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.

Heretofore, treatment of patients with primary or light chain - associated (AL) amyloidosis has been directed toward reducing the synthesis of the amyloidogenic precursor protein through conventional or high - dose cytotoxic antiplasma cell chemotherapy.

: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.

This results in the accumulation of the cytotoxic drug in cells with disabled efflux mechanisms and reduces resistance.

This is associated with a relative reduction in cytotoxic T - cell activity and a reduced capacity to destroy infected host cells and clear the virus from infected lung tissue.

Moreover, ROS generation was found treatment with 15d - PGJ2, and its cytotoxic effect could be reversed with N - acetyl - l - cysteine.

Most importantly, MX - 1 tumors, which are completely resistant to doxorubicin, were very responsive to the cytotoxic drug (doxorubicin) when it was administered in combination with MIA - 602.

CD8 + cells — also called cytotoxic T - lymphocytes (CTLs)-- matter because, among other actions, they kill cells that become infected with HIV.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

We describe a 66 - year - old man with a long - standing history of squamous cell carcinoma of the head and neck region who developed nodular - sclerosing subtype of classical Hodgkin lymphoma and primary cutaneous CD8 - positive, cytotoxic variant of mycosis fungoides over a 1 - year period of time.

On average, in comparison with GO, IMGN632 was 70-fold more cytotoxic to AML progenitors and only fivefold more cytotoxic to normal myeloid progenitors.

Following uptake into target cells, conjugates made with the PEG4Mal linker were processed to a cytotoxic metabolite that was retained by MDR1 - expressing cells better than a metabolite of similar conjugates prepared with the nonpolar linker N - succinimidyl - 4 -(maleimidomethyl) cyclohexane -1-carboxylate (SMCC).

Long - Term Intake of a Low - Casein Diet is Associated With Higher Relative NK Cell Cytotoxic Activity in F344 Rats.

Currently there are several known genes associated with Hashimoto's thyroiditis: cytotoxic T - lymphocyte associated antigen 4 (CTLA - 4), human leukocyte antigens (HLA), protein tyrosine phosphatase 22 (PTPN22) and thyroglobulin receptor gene.

The H2 concentration has been as high 98.87 percent H2 and 1.26 percent of O2, at 19.1 atm with minimal to no adverse or cytotoxic effects.

All extracts were found to have cytotoxic effects on the cancer cells, with the clove essential oil producing the highest cytotoxic effect.

A combination of corticosteroids, cytotoxic drugs, and antibiotics, with maintenance of nutrient and fluid intake may be helpful in some cases.

One of the problems with chemotherapy is that it causes a change in balance between two types of t - cells (cytotoxic cells and helper cells).

Cats with FIP are often treated with corticosteroids, cytotoxic drugs, and antibiotics.

Autoimmune disorders, which may manifest with granulomas on both the skin and other surfaces, are treated corticosteroids to reduce any inflammation and with chemotherapy, using cytotoxic drugs to suppress the immune system.