Sentences with phrase «with cytotoxic drugs»

We recently developed a mouse strain, which can be easily reconstituted without previous conditioning (irradiation or treatment with cytotoxic drugs) and we therewith defined all parameters involved in successful HSC transplantation.

Not exact matches

Most medications are safe in breastfeeding, with rare exceptions such as cytotoxic chemotherapy drugs.

Therefore, to overcome chemoresistance mediated by EMT, drug screening efforts have focused on eliminating the mesenchymal subpopulation by searching for drugs with preferential cytotoxic effects on mesenchymal, rather than epithelial HMLE subpopulations [7].

Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.

: We conclude that treatment of triple negative breast cancers with growth hormone - releasing hormone antagonists reduces tumor growth and potentiates the effects of cytotoxic therapy by nullifying drug resistance.

This results in the accumulation of the cytotoxic drug in cells with disabled efflux mechanisms and reduces resistance.

Most importantly, MX - 1 tumors, which are completely resistant to doxorubicin, were very responsive to the cytotoxic drug (doxorubicin) when it was administered in combination with MIA - 602.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

A combination of corticosteroids, cytotoxic drugs, and antibiotics, with maintenance of nutrient and fluid intake may be helpful in some cases.

Cats with FIP are often treated with corticosteroids, cytotoxic drugs, and antibiotics.

Autoimmune disorders, which may manifest with granulomas on both the skin and other surfaces, are treated corticosteroids to reduce any inflammation and with chemotherapy, using cytotoxic drugs to suppress the immune system.