Those fish treated
with dasatinib were able to swim further and for longer than those in a control group.
The researchers confirmed these findings in a mammary carcinoma mouse model — treatment
with dasatinib just a few days after administering two high doses of chemotherapy prevented tumor growth and increased survival rates.
Not exact matches
Treating cells simultaneously
with docetaxal and
dasatinib or administering
dasatinib after a longer period of time did not produce the same effects.
«Although TKIs such as the first - generation TKI imatinib mesylate (IM) and the second - generation TKIs
dasatinib and nilotinib have markedly improved the prognosis of patients
with chronic phase CML, a cure remains elusive.
In one report, a patient
with an L576P KIT mutation in whom imatinib therapy had previously failed experienced marked reduction in tumor burden in response to
dasatinib treatment.
A drug called
dasatinib was found to be safe and effective for children
with chronic myeloid leukemia, according to a clinical trial published in the Journal of Clinical Oncology.
Several targeted drugs (e.g., imatinib [Gleevec ®],
dasatinib [Sprycel ®]-RRB- are effective for treating CML because they attack cells
with the Philadelphia chromosome, the genetic abnormality that is the hallmark of this type of leukemia.
A phase I study of
dasatinib in children and adolescents
with chronic myeloid leukemia (CML) and other malignancies determined dosing for further studies and suggested the drug is well tolerated and effective in these patients.