Sentences with phrase «with decreased availability»

Availability of resources such as usable water will also depend on changing rates of precipitation, with decreased availability in many places but possible increases in runoff and groundwater recharge in some regions like the high latitudes and wet tropics.

«Climatic refuges, such as mature tropical forests, may be important for many resident tropical bird species faced with the decreasing availability of mature forests coupled with increases in the severity of El Niño - associated dryness.»

The Rainy River court district also includes Fort Frances and Atikokan, Ont., all of which have seen declining numbers of court days with the decreasing availability of judicial resources in recent years, says Morgan.

Not exact matches

The study notes that a 99 % population increase since 1950 combined with a 127 % increase in water use has further decreased water availability, making it increasingly difficult to replenish water supplies after a drought.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

With an overall decrease in both water availability and water quality across the country, Horizon Elite represents a huge win for operators and for the industry.»

Similarly, studies by Ferguson and by other researchers, such as economist Todd Kendall, have found a decrease in rates of rape that coincides with increased availability of pornography.

Positive: Increased organic matter if increased productivity; increased nitrogen availability Negative: Decreased organic matter (with increased decomposition rates); decreased mycorrhizal support; increased soil acidity; increased release, or decreased removal, of atmospDecreased organic matter (with increased decomposition rates); decreased mycorrhizal support; increased soil acidity; increased release, or decreased removal, of atmospdecreased mycorrhizal support; increased soil acidity; increased release, or decreased removal, of atmospdecreased removal, of atmospheric CO2

Aging - associated increases in oxidative damage to key enzymes results in their structural deformation and decreased binding affinity for the co-enzyme, causing a decrease in enzyme funtion.8 Ames» research has demonstrated that increasing the availability of acetyl L - carnitine and α - lipoic acid, two nutrients that serve as mitochondrial enzyme co-factors, restores the velocity of the reactions (KM) in the related enzymes, and thus restores aging mitochondria's ability to produce youthful levels of ATP.9 10 11 12 13 Part II focused on the inter-relationships among the folate, methylation and transsulfuration pathways, whose dysfunction results in increased free radical production coupled with disruption of glutathione (GSH) synthesis, thus accelerating mitochondrial decay and aging.

The phosphoric acid group of phytic acid can bond with proteins, amino acids, starch, and lipids making them less soluble decreasing their availability for digestion.

The end result of endotoxemia may be decreased tryptophan and enhanced kynurenine availability, along with compromised serotonergic functioning [32 — 34].»

The exponential growth of the use and availability of smartphones and tablets, combined with the decrease in acquisition costs of these devices, make a suitable learning tool for special needs children.

Doesn't Amazon realize that (1) the free books we've downloaded still provide them with data to recommend non-free books, several of which I've purchased from their recommendations and (2) those of us who still use e-ink Kindles many not be as inclined to buy a Kindle Fire now — if the availability of free Kindle books at Amazon decreases, we might as well buy the iPad Mini instead.

Malabsorption of cobalamin can occur from a combination of decreased availability of pancreatic intrinsic factor and pancreatic proteases necessary to release cobalamin from R proteins, coupled with overgrowth of cobalamin binding intestinal bacteria.

And the decrease in Air France transatlantic award availability isn't all that different than what we've seen with Lufthansa lately.

• «Decreased water availability due to increased temperature and longer periods of time between rainfall events, coupled with an increase in societal demand is very likely to affect many sectors of the Southeast's economy.»

What will happen as a result is quite predictable: Greatly increased rates for electric power, decreased availability of the electric power so vital to our way of life, decreased reliability of the electric grid, a lower standard of living, decreased competitiveness of US products in world markets since most countries do not have such regulations, and Communist - style central control of the electric generating industry by a Washington - based bureaucracy with no understanding of the industry.

Although these hydrological changes could potentially increase soil water availability in previously snow - covered regions during the cool low - ET season (34), this effect would likely be outweighed by the influence of warming temperatures (and decreased runoff) during the warm high - ET season (36, 38), as well as by the increasing occurrence of consecutive years with low precipitation and high temperature (Fig. 4A).

With city populations continuing to rise, the availability of parking keeps decreasing.

• Streamline the patient transfer procedure by implementing a smooth online re-registration process with 14 veterinary hospitals onboard • Introduce a «comfortable» surgical cage to the facility, resulting in decreased incidents of animal discomfort • Greet clients and provide them with information regarding the facility's services • Engage animals / pets by greeting them and performing gestures to keep them comfortable • Register new pets / animals into the facility database by ensuring completeness and accuracy of data • Receive and service calls for information and schedule appointments over the telephone and in person • Provide reminders to clients regarding vaccinations and pre surgery and surgery procedures • Assist in restraining animals during examinations and sampling procedures • Ascertain that blood and urine samples are sent to corresponding labs for testing purposes • Follow up on labs to obtain diagnostic reports and inform clients of their availability • Ascertain the cleanliness, sanitization and maintenance of reception area and treatment rooms

Consistent with preclinical studies, adults with depression have been reported to have multiple alterations of the hypothalamic pituitary adrenal axis (9), increased cerebrospinal fluid corticotropin - releasing hormone (10), elevated cerebrospinal fluid norepinephrine concentration (11), decreased cortical γ - aminobutyric acid measured in vivo using proton magnetic resonance spectroscopy (12), and multiple indicators of altered serotonin (5 - HT) functioning (13), including reduced serotonin transporter (5 - HTT) availability as evidenced by reduced [123I] β - CIT spect binding (14).

For instance, Staley and colleagues showed that serotonin transporter availability decreased in the diencephalon in patients with major depression, compared to healthy controls, and such a decrease was more prominent in women than men (Staley et al. 2006).

In multivariate analyses, after adjusting for other covariates, the odds of poorer school performance increased with increasing weekday television screen time and cable movie channel availability and decreased with parental restriction of television content restriction.