Sentences with phrase «with decreased expression»

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

Accordingly, the increased p53 activity in p53Δ31 / Δ31 fibroblasts correlated with a decreased expression of 4 genes implicated in telomere syndromes.

Not exact matches

The chief ends in life are individual expression and success, with decreasing attention to the public good and even less ability to talk about the public good.

Michaelsson G, Ahs S, Hammastrom I, Pihl Lundin I, Hagforsen E. Gluten - free Diet in Psoriasis Patients with Antibodies to Gliadin Results in Decreased Expression of Tissue Transglutaminase and Fewer Ki67z Cells in the Dermis.

They found that elevated anxious temperament is associated with decreased messenger RNA expression of two neuropeptide Y receptors, Y1R and Y5R, in the central nucleus of the amygdala, a region of the brain that plays an important role in regulating fear and anxiety.

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

Borrelli said they observed a remarkable decrease in expression levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones — particularly those associated with reduced gene activity.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

Importantly, patients with mutations in a single copy of NKX2.1 often have Brain - Lung - Thyroid Syndrome, which is characterized by respiratory distress after birth and accompanied by decreased surfactant protein expression.

AMD3100, alone or in combination with VIC - 008, decreases expression of the immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway modulates PD - 1 expression.

Two mutations that decrease expression of this gene were found in high frequencies in people with the darkest skin.

A recent human study also indicated a genetic association of the αCaMKII gene with bipolar disorder, and decreased expression of αCaMKII has been observed in postmortem brains of patients with bipolar disorder.

They performed transcriptional profiling of HSPCs from NOD mice, which revealed decreased PD - L1 expression confined to HSPCs, compared with C57BL / 6 controls.

Remarkably, the relative expression levels of all marker genes were only slightly decreased when R206H ACVR1 and Q207D caACVR1 cultures were cotransfected with Noggin, whereas cells expressing the wild - type ACVR1 or empty viral vector showed clear downregulation of all analyzed marker genes for chondrogenesis.

While expression levels of all marker genes remained almost unchanged in wild - type ACVR1 cultures compared with the empty viral vector, the expression profile induced by caACVR1 Q207D displayed evidence of advanced chondrogenic differentiation as shown by decreased levels of the early differentiation stage marker collagen type II together with enhanced expression of the later - stage markers Ihh and collagen type X. Indian hedgehog has been shown previously to be induced by BMP signaling transmitted via the ACVR1 receptor (9).

Analyses were performed with 5 animals per group (control, 3 h of hypoxia, and 24 h or recovery after 3 h hypoxia) to decrease bias that may be introduced by donor - specific gene expression patterns.

Antennae - deprived workers, however, exhibited a tendency toward a 20 % decrease in the induced Acks expression level compared with the intact workers (Figure 5N).

Corresponding to upregulated TRF2 expression at 80μM, stem cell markers like CD44 and Oct4 were also observed to be upregulated in Clonospheric HCT116 as compared to Parental HCT116 (Fig. 3a and 3b) Decreasing CD24 expression in clonospheric HCT116 was observed which correlated well with increased stem cell expression (Fig. 3b).

Genetic data combined with information on gene expression and epigenomics in relevant tissues, and clinical information, can provide clues about the effects of genetic changes within an individual's genome that increase or decrease one's risk of developing type 2 diabetes and its complications, including heart and kidney disease.

Then they compared each person's transcriptome to the average transcriptome of people at the same age, intensively exploring about 100 genes whose expression were found to increase or decrease with aging.

While TET1 expression was decreased in patients with diabetes (q < 0.15), numerous other candidate genes were only nominally regulated (Supplementary Table 21).

Estrogen and progesterone decrease let - 7f microRNA expression and increase IL - 23 / IL - 23 receptor signaling and IL - 17A production in patients with severe asthma.

Our findings of decreased GYS2, ELOVL6, and FADS1 expression in adipose tissue from patients with diabetes could potentially explain the reduced glucose uptake and impaired ability to store lipids in the adipose tissue of these individuals.

Our result showed that, among 26 cases with decreased DDX3 expression status, 20 cases (77 %) also showed simultaneous p21waf1 / cip1 down - regulation, and the correlation between the expression status of DDX3 and p21waf1 / cip1 was statistically significant (P = 0.039; Fig. 5C).

(14,15)-RRB- have found age - related satellite cell attrition consistent with the senescence of a subset thereof; moreover, one such study (15) reported that decreases in the number and quality of satellite cells with aging are reliably associated with elevated expression of p16Ink4a (contrary to (14)-RRB-, and with secretory and proteomic abnormalities consistent with a rising burden of senescent cells.

Transient transfection of ALCL cells with specific mTOR siRNA (20 μg) resulted in almost complete inhibition of mTOR protein expression at 48 hours (B) associated with a substantial decrease of p - p70S6K and p - rpS6 (not shown).

These featured similar anorexigenic effects of intranasal insulin with decrease in meal frequency and total food intake together with comparable changes in hypothalamic gene expression (262, 264).

We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

Consistent with a decrease in E-cadherin expression, MDA - MB 231 F3 and BCM2 F3 cells had increased nuclear expression of Snail and cytoplasmic expression of a mesenchymal marker vimentin (Figure 6c).

We found that depletion of ABL kinases in breast cancer cells decreased STAT5A mRNA expression (Fig. 6D) without decreasing total STAT5 protein abundance as measured by Western blotting with antibodies that detect both STAT5A and STAT5B (Fig. 7D and fig.

CCHa2 expression was decreased by starvation and recovered by re-feeding the starved larvae with yeast paste.

Using a TCGA data set with 971 invasive breast cancer patients, we found that patients with alterations in the expression of ABL2 and eight validated downstream targets (TAZ, AXL, CTGF, STAT5A, STAT5B, TNC, IL6, and MMP1) exhibited decreased disease - free survival (Fig. 8A).

In the HepG2 cells, the expression of p53 reached a maximal level with treatment of 10 nM ActD, and decreased with doses of 100 nM or higher for 6 h (Fig. 1B).

Decrease in HIF -1-alpha expression correlates with increased concentration of metformin hydrochloride, as described in literature.

Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression

Treatment of iLpldf mice with ApoC - III ASO decreased Apoc3 mRNA levels (Figure 8A) and protein expression (Supplemental Figure 6A) and reduced plasma TGs (Figure 8B) and TGs in CR / VLDL particles (Figure 8C).

In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up - regulation of a core activation program, coupled with a decrease in cell - to - cell variability.

Furthermore, movement - independent ZENK expression in the forebrain of night - migratory birds performing magnetic orientation at night is confined to Cluster N [with the strongest activation in distinct subregions (the shell surrounding the DNH nucleus)-RSB-, as shown by the detailed quantification of ZENK expression within Cluster N performed in this study], and this expression massively decreased in corresponding brain areas of non-migratory songbirds and in all bird species during daytime [13].

In particular, CYP4F2 rs2108622 was associated with increased CYP4F2 expression while CYP4F11 rs1060467 was associated with decreased CYP4F2 expression.

Consistent with the demonstration that LARP7 is necessary for the integrity of the 7SK snRNA (He et al., 2008), the reduced LARP7 expression in invasive breast cancer cell lines was accompanied by a decrease in 7SK snRNA (Figure 1D).

We confirmed that the protein level of APC was elevated and the expression of miR - 150 was decreased in the human breast cancer xenograft cells transfected with the anti-miR-142-3p lentivirus (Figure 5E and Figure 7B).

With my doctor's guidance, I discovered I could influence the expression of the TTR gene, and consequently decrease my pain, simply by changing my environment and lifestyle.

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

Despite this possibility, mevinolin, the active ingredient in red yeast rice, is capable of reducing 7 - dehydrocholesterol levels, 22 and simvistatin (Zocor) not only inhibits the synthesis of mevalonate but also enhances the conversion of 7 - dehydrocholesterol to cholesterol by increasing the expression of 7 - DHCR.23 Simvistatin thereby hits the pool of 7 - dehydrocholesterol with a double - whammy, both decreasing its synthesis and increasing its degradation.

ERβ expression has been revealed to be greatly decreased in malignant prostate tissue, reaching nearly undetectable levels with tumor progression in more than 75 % of cases.

Furthermore, deleterious stress responses are associated with a decrease in the expression of brain - derived neurotrophic factor (BDNF), a response quite the opposite of calorie restriction and intermittent fasting, where increased concentrations of BDNF have been observed in numerous studies (4).

There is evidence that people with genetically decreased expression of leptin receptors are more susceptible to certain infections.

The normal - protein group also saw decreased gene expression of genes associated with oxidative stress, while the high - protein group increased the expression of genes associated with oxidative stress.

The substance of the cases brought before the courts has also varied over time, with protest and free expression cases decreasing markedly through 1992 (see Figure 2a).