Sentences with phrase «with decreasing ability»

With the onslaught of acidity from foods and stress along with decreasing ability of the body to keep up with buffering all this acidity our bodies often can not keep up adequately with sufficient production of bicarbonates (especially true as we age or if we have a chronic stress).

In addition, the overall phenolic content of EVOO has been associated with a decreased ability of cancer cells to regenerate.

An increased need to eliminate combined with a decreased ability to locate or access a litter box can prompt your cat to wake up and wander around.

Many survivors have to live with a decreased ability to function and enjoy life.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

In one recent study, Choi and several colleagues wrote that smartphone addiction, like other impulse - control disorders, can «interfere with school or work; decrease real - life social interaction; decrease academic ability; and cause relationship problems.»

The results are consistent with a simple experience good model where biomedical misconceptions decrease consumers» ability to infer quality, which retailers exploit by selling lower quality medicines.»

For in - house recruiters, the ability to share applicant information with the relevant hiring manager, as well as schedule interviews and gather feedback from those same hiring managers within one system can save time and decrease the number of days in the hiring cycle.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The chief ends in life are individual expression and success, with decreasing attention to the public good and even less ability to talk about the public good.

Making your own granola allows you the ability to decrease the amount of fat used by replacing it with applesauce.

There are strong speculations that the French playmaker could exit the team with decreasing confidence in his abilities by the coach Jose Mourinho but then the huge financial investment in him is a major hindrance.

When assessing potential targets, in any position, efficiency is king; with time a precious commodity and space on the pitch decreasing through the proliferation of highly effective pressing tactics, the ability to do things quickly and accurately becomes invaluable.

TRU Calm will help you Teach and discipline more effectively, build a beautiful and bulletproof Relationship with your child and Upgrade yourself and your own emotional intelligence and ability to decrease daily stress, feel more relaxed and model healthy self - regulation skills to your children.

Furthermore, it is now clear that all kinds of crying (i.e. fussing, crying and inconsolable crying) is prolonged, that this prolongation occurs only in the first few months, and that inconsolable crying is almost unique to the first few months of life.3, 40 The «unpredictability» of the crying, and of the caregiver's ability or inability to soothe the infant is most likely due to the facts that (1) the infant cry in the first few months is a reflection of the organization of its behavioural states (crying, awake alert, sleeping), rather than an intentional «signal,» 14 (2) that behavioural state changes occur in «steps» rather than due to increases or decreases in arousal7, 41 and (3) infants are resistant to behavioural state change unless they are in a transitional phase in which they are «ready» to change state.7 Finally, there is now good evidence that the proportion of infants that have evidence of organic disease to explain their crying is less than 5 %.8, 42,43 In the absence of other compromise, infants with «colic» have as good an outcome as infants without «colic.»

Breast milk jaundice can be caused by substances in mother's milk that decrease the infant's liver's ability to deal with bilirubin.

The approach halts further necrosis and can save a baby's life, but it often leaves infants with insufficient intestine and puts them at risk for long - term complications, such as short bowel syndrome, which requires feeding support for life due to the intestines» decreased ability to absorb enough nutrients.

Babies who can roll themselves over are at a significantly decreased risk of SIDS, which experts believe is because babies with that ability have also developed the maturity to sense trouble during sleep and move into a safer position.

As always, do follow up with your pediatrician if you become really concerned or you notice any significant changes / decreases in your baby's abilities.

Childhood Development expert, Anastasia Moloney, discusses ways to Increase your ability to communicate with your Infant while decreasing frustrations through baby signing

It would be best to talk with your doctor and your baby's doctor to ensure safety, as taking melatonin all the time can decrease your body's natural ability to make it.»

You have the ability to decrease the stress and last - minute drama, if you respectfully and cordially confirm all the details with your children's mom well in advance.

In frogs with the disease, the skin's ability to take up sodium and potassium ions from the water decreases by more than 50 per cent, Jamie Voyles of James Cook University in Townsville, Queensland, Australia, and his colleagues found (Science, DOI: 10.1126 / science.1176765).

The scientists found specifically that the bacterium Pseudomonas aeruginosa can produce specific molecular factors that dramatically increase or decrease an antibiotic's ability to kill Staphylococcus aureus, another bacterium that often co-infects with P. aeruginosa.

Although testosterone levels and the ability to perform self - care activities both decrease with age, it is unclear whether one or the other is a cause or an effect of aging, or if they are both due to a common third cause, Hsu said.

BRAF mutations, which occur in about 40 to 50 percent of these patients, have been associated with aggressive tumors and decreased ability of tumors to respond to radioactive iodine, typically the first line of treatment in these patients.

«At the same time, we'd like to develop the ability to process these materials at lower temperatures and with decreased amounts of harmful solvents.

Guessing that the reduced ability to control force in patients with PD was related to decreased dopamine — which makes it harder to «recruit» neurons for a particular task — the researchers devised a brain stimulation experiment to further test their hypothesis.

People with Parkinson's disease (PD) tend to slow down and decrease the intensity of their movements even though many retain the ability to move more quickly and forcefully.

They found that by adding it to the high - fat diet, the compound would decrease the level of obesity in the animals and would increase their ability to deal with increased blood glucose levels.

They also saw that antibodies known to exhibit some effectiveness acted to prevent gp120 from opening, and that these effects correlated with a decrease in the virus» ability to infect cells.

There is some evidence that, as we age, our ability to metabolize alcohol decreases so alcohol might remain in our systems longer to interact with medications.

By testing athletes with highly developed stereo acuity, researchers determined that repetitive training decreased their processing time, and that this ability was persistent for six months after the training ended.

Lack of sleep has long been connected with reduced ability to concentrate, trouble learning, decreased attention to detail and increased risk of motor vehicle accidents.

We're seeing encouraging results, including the development of more effective drugs with increased efficacy and decreased toxicity, and the ability to better use existing ones, with improved delivery and fewer side effects.

Vaccinating older individuals is problematic, as the effectiveness of most vaccines decrease with age, with maximal responses often as low as 30 % in the over 70s.5 Nevertheless, vaccination programmes demonstrate the ability to reduce disease burden in the elderly as well as offering a tool to observe immune responses in vivo in humans.

These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.

June 13, 2013 Age - related smelling loss significantly worse in African - Americans The ability to distinguish between odors declines steadily with age, but a new study shows that African - Americans have a much greater decrease in their sense of smell than Caucasians.

Our findings of decreased GYS2, ELOVL6, and FADS1 expression in adipose tissue from patients with diabetes could potentially explain the reduced glucose uptake and impaired ability to store lipids in the adipose tissue of these individuals.

For rare cell populations, these losses in recovery and viability present challenges for end users performing research on a process with potential for transfer to clinical scale by decreasing the ability for process time and cost efficiency.

«Their ability to absorb B12 from food decreases with age.»

Lower concentrations of 1,25 D3 in African Americans, likely due to a decreased ability to absorb vitamin D from sunlight, correlate with increased susceptibility to infection.

The ability of a population to behave as a portfolio, however, might decrease with increased connectivity (exchange) between sub-populations due to two processes.

«Warning signs are changes in mood or personality, withdrawal from work or social activities, decreased or poor judgment, misplacing things and losing the ability to retrace steps, new problems with words both in speaking and writing, trouble understanding visual or spatial relationships, confusion with time or place, difficulty completing familiar tasks, challenge in planning or solving problems and memory loss,» according to The Alzheimer's Association.

Reading is a multifactorial process that is influenced by psychological, physiological, environmental, sociological and linguistic factors.1, 2 From an optometrist's perspective, a decrease in reading ability may be associated with poor visual acuity, unstable binocular vision, or ocular disease.3 It is therefore important that people with poor reading comprehension receive a comprehensive oculo - visual assessment.

It can also result in decreased mental ability and energy levels, depression, and issues with sexual function like loss of libido and erectile dysfunction.

Research has found that 60 percent of those with chronic migraines have genetic changes that decrease their body's ability to metabolize magnesium, which relaxes blood vessels in the brain.

Fiber also reduces the amount of free cholesterol in the blood — this, together with its ability to decrease the intake of calories, makes it a great natural way to enhance your body fat loss.

We must exercise our ability to produce saliva or deal with a dry mouth and all the ails that come with decreased saliva production.