Sahakian agrees that other subtypes of depression are likely to be identified
with different biomarkers.
Not exact matches
A composite
biomarker score, created by combining two
different ratios, predicted the presence or absence of A-beta plaques in the brain
with about 90 percent accuracy in both groups of patients, the researchers found.
They say that the system can be constructed
with more than five
different aptamers, allowing detection of multiple
biomarkers at once.
Association of a protein
biomarker with any given disease process, for example, needs to be assessed in terms of disease - independent, confounding factors that may modulate protein expression levels among
different individuals.
Tumor tissues of six patients were stained for two
different tumor
biomarkers (CA IX and Topo - I) before and after treatment
with CRLX101.
This may be associated
with sex hormones and their receptors,
different body fat distribution and related
biomarkers, such as higher adiponectin, which are discussed earlier.
She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration
with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies
different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of
biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.
Previous experience also includes a role as Senior Scientist
with Eli Lilly and Company where she was part of the Pharmacogenomics and Translational Medicine Group in charge of discovering and validating genetic / genomic
biomarkers in
different therapeutic areas (oncology, cardio - metabolic and neurosciences).
Researchers are also trying to learn about: - The level of MM - 121 that remains in the human body at
different time points when MM - 121 is combined
with docetaxel or pemetrexed - The relationship between the
biomarker, heregulin, and cancer cell growth (disease progression) in people dosed only
with docetaxel or pemetrexed.
Researchers followed a subset of 1,139 subjects and found that those
with the greatest increases in urinary polyphenols had significantly lower levels of five
different biomarkers of inflammation, such as adhesion molecules, interleukin, tumor necrosis factor alpha, and monocyte chemotactic protein.