Sentences with phrase «with drugs designed»

On the other hand, first clinical trials with drugs designed to target cancer stem cells are now under way, so far yielding moderately positive results.

Moreover, they suggest, laboratory experiments with drugs designed to clear up these cellular «traffic jams» restored normal transport in and out of the nucleus and saved the cells.

They want to know how it will help cure cancer; they speculate about customized medicine, with drugs designed for the individual, not the population.

Treat with the drug designed for dogs.

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

That design can hit Americans with high deductibles who rely on high - cost drugs especially hard.

Other sources provide services to keep costs low: Science Exchange connects scientists with experts; and Transcriptic is a cloud - based biotech lab testing experimental drugs, while Gingo Bioworks designs custom microbes for customers.

Langer, an MIT Institute Professor with some 750 patents issued or pending worldwide, was one of the first people to apply chemical engineering methods to medical applications, pioneering the use of specially designed polymers for targeted drug delivery and tissue regeneration.

«It essentially gives us a periodic table,» Ron DePinho, President of MD Anderson Cancer Center says, which has provided us with both diagnostic and therapeutic value as well as helped us design clinical trials to accelerate the development of new cancer drugs,».

This drug is designed to reduce the build up of a neural protein in the brain called alpha - synuclein that is associated with the disease.

The conscience you try and drown out with alcohol, drugs, and sarcastic comments... Well it turns out that conscience of yours was designed by God to wake you up out of your foolishness.

Every since mankind has been as the Apostle described us in his epistle (Again, 2 nd Timothy 3:1 - 5; see also what Jesus said in Mark 7:20 - 23), the only thing that has «advanced «at our hands is our architecture, our technology, and our search for medicinal cures for what ails us.No one is denying that we've done tremendous good with these various advances, but we've also done awful, vicious, horrendous atrocities and brutalities as well.I've heard it quoted that out of all the centuries, millennia that we've considered ourselves «civilized», we've had only a few hundred years where something approximating peace has held sway among us.So again, I'm all world seeking to «make the world a better place», as it were; I just believe that mankind in his present moral, ethical, and spiritual configuration is capable of doing so.We can always enhance out technological prowess, improve our architechural designs, and make our drugs more powerful, but what about our hearts?

DRUGS AND ALCOHOL: just say no is a beautifully illustrated handout designed specifically for fathers, to help them communicate effectively with their children on the topics of drugs and alcDRUGS AND ALCOHOL: just say no is a beautifully illustrated handout designed specifically for fathers, to help them communicate effectively with their children on the topics of drugs and alcdrugs and alcohol.

I believe that as women we were created to do this and that drugs only interfere with the natural birthing process and what our bodies are designed to do.

Meanwhile, Cuomo ended his three - day State of the State tour Wednesday with a speech in Albany that featured a renewed call for ethics reform and a proposal designed to cap the sky - high prices of prescription drugs in New York.

The NYPD sponsored events are designed to increase awareness about crime and drug prevention, along with strengthening neighborhood spirit, according to Borough President Ruben Diaz.

The county lawmakers expressed particular concern that Erie County is spending $ 301,000 a year to staff a 24 - hour addiction hotline, designed to connect addicts with treatment and be a one - call resource for drug treatment referrals and advice.

This program is designed to target and shut down known drug markets by establishing programs through which police can collaborate with both prosecutors and the general public.

Randolph Nesse and Kent Berridge, psychiatric investigators with the Institute for Social Research at the University of Michigan in Ann Arbor, reported in Science that medicine may never win the war against drug addiction because «it is rooted in the fundamental design of the human nervous system.»

«This discovery opens the way for the rational design of a new generation of antipsychotic drugs, hopefully with more desirable effects and fewer side effects.»

In Solms and Panksepp's vision of the future, depression treatment might blend various types of therapy — sometimes including psychoanalysis — with drug regimens designed to target the neural circuitry involved in a well - understood emotional response.

However, as many anti-inflammatory drugs are already available, there may be a relatively short path to designing clinical trials for drugs that modulate the inflammatory response in people with neurodegenerative disease.

We currently do not know how these genetic risk factors affect the chemistry of the brain and cause specific symptoms, so it is not yet possible for scientists to design drugs to relieve symptoms shown by people with a particular genetic variant.

This open layout means that Bio21 students, primarily graduate students and postdocs, are assured of opportunities to interact with researchers from a variety of disciplines; a biochemistry student, for example, has the opportunity to work — and chat — with chemists who are designing molecules for potential drugs, or geneticists, or pharmacologists.

Once researchers understand the rules for how to get specific shapes with TZPs that also assemble into larger structures, they can design materials with desired functions — for example, a membrane for a battery, a catalyst for a fuel cell, or even a therapeutic drug.

A paper published today in Nature describes how a group of scientists from Stanford University, collaborating with the MRC in Cambridge, The University of California, San Francisco and the Universities of Melbourne used cutting - edge technology to design a smarter drug to combat the resistant strain.

But first, Stegh and colleagues want to hone the particle design and to investigate treatments that combine miR - 182 with established chemotherapy drugs in mouse models.

Intelligent design became a scientific reality this year with the report that researchers had custom - made a lifesaving microbe — one that helps make a much - needed drug against malaria.

As Cournia contemplated returning to her home nation, she researched how her subfield of computer - aided drug design would fit in with the strategic initiatives of Greek institutions.

Most drugs are designed to interfere with a specific disease pathway by elbowing their way into important spots inside the cell.

UCLA chemists and molecular biologists have for the first time used a «structure - based» approach to drug design to identify compounds with the potential to delay or treat Alzheimer's disease, and possibly Parkinson's, Lou Gehrig's disease and other degenerative disorders.

Structure - based drug design, in which the physical structure of a targeted protein is used to help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.

The researchers targeted mTOR with an experimental drug based on a prototype first designed by Shokat, a chemist and an expert in designing molecules to target this type of protein, called a kinase.

In the meantime, it cautions parents who use them in that age group to, among other things, carefully follow dosing directions, only use measuring spoons or cups that come with or are specifically designed to be used with the drugs, and remember that the drugs, at best, temporarily mask symptoms of but neither cure nor shorten the duration of colds or coughs.

He's also likely to spur the FDA to follow the course laid out by agency cancer czar Richard Pazdur in speeding new approvals, possibly setting up a special unit aimed at orphan drugs to hasten OKs with smaller, better designed clinical trials.

• Penalties of up to $ 10 million may be imposed for violations of the new REMS (risk evaluation and mitigation strategy) provisions, designed to manage a known or potential serious risk associated with a drug or biological product.

Professor Davis, author of the popular Penguin paperback The Compatibility Gene, concludes: «The practical application of this basic research comes from bouncing around our ideas with scientists working on drug design.

«Overall,» Dr. Schwartz added, «the study underscores the importance of rational drug design, in which drugs are designed to interact with specific molecular pathways involved in a particular disease.

Scientists say that the new design may eliminate the problems with the failed 2002 vaccine (manufactured by Elan Corporation, an Ireland - based drug company).

«On the other hand the US Food and Drug Administration has taken the more conservative approach which recognises that SQUIRE was designed for all - comers without prior selection, and this subgroup analysis is insufficient evidence to conclude that patients with EGFR negative tumours are not candidates.»

The investigators designed the study in consultation with the U.S. Food and Drug Administration to enable potential future licensure of the manufacture of purified human pancreatic islets.

A Georgetown University professor published in the online journal PLOS ONE the first study explaining why drugs designed to fight off malaria stop working in some people with the disease.

Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.

These new nanoparticles are equipped with specially designed nanovalves that can control release of anticancer drugs from thousands of pores, or tiny tubes, which hold molecules of chemotherapy drugs within them.

With this and similar blueprints, pharmaceutical companies should have an easier time designing lipoxygenase inhibitor drugs to douse the immune system's response in such diseases.

Working with the pharma and biotech industries, Poirier focuses on both performing the genetic tests in his laboratory and designing the clinical drug trials.

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

It was conducted under a special protocol assessment with the US Food and Drug Administration, which considers an uncompleted Phase III trial's design, clinical endpoints, and statistical analyses acceptable for FDA approval.

With «a little chemistry and some trial and error,» they should be able to design drugs which mimic arachdonic acid, but plug the pocket.