Sentences with phrase «with efflux»

So, the benefit that we have with the efflux pumps, or the benefit that we have with the natural antimicrobials is we don't have that — that pail, bailing out the water.

This picture was suddenly complicated in 1999, when Gerd Jürgens and his colleagues at the University of Tübingen in Germany discovered a mutant of the model plant Arabidopsis with efflux pumps everywhere in the cell.

We thought, if the latter scenario is operative, then a molecule comprising the minimal portion of the ADEP that is recognized by the pump could competitively interfere with efflux of the ADEP.»

Not exact matches

Prolonged oral administration of a pan-retinoic acid receptor antagonist inhibits spermatogenesis in mice with a rapid recovery and changes in the expression of influx and efflux transporters.

The AcrA - PPMO also was effective against the human pathogens Klebsiella pneumoniae and Salmonella enterica, since those bacteria contain the same efflux pump with a matching gene sequence, Dr. Greenberg said.

The UTSW experiment focused on Escherichia coli (E. coli) and bacterial pathogens with genetically similar efflux pump complexes.

Bacteria that use these «efflux pumps» and that are treated with the new compound become sensitive to antibiotics they were previously resistant to.

Sello and a team of researchers from Brown have come up with a new strategy that may help sneak drugs past the efflux guards.

«We study a lot of efflux pumps to understand antibiotic resistance,» said Yu, an Iowa State professor with appointments in physics and astronomy; chemistry; biochemistry, biophysics and molecular biology; and the U.S. Department of Energy's Ames Laboratory.

In fact, the team showed that the fragment approach worked better than combining ADEPs with reserpine, a well - known efflux inhibitor.

The Solution: Working with pathogenic bacteria would be far too dangerous in a school setting, so Delgado focused on disabling an efflux pump in the common bacterium E. coli.

«As a first in this field, we proposed the approach of essentially «screwing up» the efflux pump's protein assembly, and this led to the discovery of molecules with a new type of antibacterial activity,» said co-author Jeremy Smith, who serves as a UT - ORNL Governor's Chair and director of the UT - ORNL Center for Molecular Biophysics.

Indeed, we found that long - term drug treatments were associated with increased expression of several ABC efflux transporters and influx transporters.

A, The expression of several ABC efflux transporters, including Abcb1a, Abcb9, Abcc5, and Abcc10, were significantly up - regulated in testes after long - term drug treatment as compared with the control.

Sanny S. W. Chung, Xiangyuan Wang, Debra J. Wolgemuth; Prolonged Oral Administration of a Pan-Retinoic Acid Receptor Antagonist Inhibits Spermatogenesis in Mice With a Rapid Recovery and Changes in the Expression of Influx and Efflux Transporters, Endocrinology, Volume 157, Issue 4, 1 April 2016, Pages 1601 — 1612, https://doi.org/10.1210/en.2015-1675

A significant population of cells was observed to efflux Hoechst 33342 dye when treated with increasing concentration of Bleomycin (20, 40, 60, 80 μM)(Fig 1a and 1b).

This intrinsic penetration barrier, combined with potential for rapid efflux often leads to where a compound with good intrinsic activity at an intracellular or periplasmic target displays poor whole cell antibacterial activity.

Additionally, cells treated with MIA - 602 showed a significant increases in Calcein dye retention, indicating that efflux pump function was reduced.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

This results in the accumulation of the cytotoxic drug in cells with disabled efflux mechanisms and reduces resistance.

Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on - chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions.

An effect of walnuts on ex vivo cholesterol efflux was observed with whole serum but not apoB - depleted serum; in addition to HDL, LDL can serve as an acceptor of free cholesterol in the reverse cholesterol transport pathway (39), indicating that walnuts may have a greater effect on global cholesterol efflux than HDL - specific efflux.

The rate of He is approximately zero order and any efflux of He must be first order with respect to He.

The fit has a correlation coefficient of 0.997; but in reality sucks as my model assumes that CO2 efflux is first order with respect to CO2, where in fact it is probably closer to second order.

Kim Y, Park S - J, Lee B - Y, Risk D (2016) Continuous measurement of soil carbon efflux with Forced Diffusion (FD) chambers in a tundra ecosystem of Alaska.

To understand what and what we can and can not do, may I point out a good mental model with which to use when thinking about influx, efflux and steady state levels; the Hoover dam.