Sentences with phrase «with endothelial»

As a general maintenance dose, the authors of the study suggested individuals take a 500 mg, or more, daily dose of vitamin C during periods of stress, deficiencies, or anyone dealing with endothelial dysfunction.

For example, I recall exotoxins from animal products being a causative factor for inflammation and the corresponding cascading of events with endothelial damage, which is then spackled over with cholesterol as a repair mechanism.

Determine the mechanisms by which T cells promote antibody and complement interactions with endothelial cells resulting in activatation and release of cytokines.

In fact, several of the best characterized anti-angiogenic compounds were initially detected and selected for their capability to interfere with endothelial cell growth.

Determine the mechanisms by which complement interactions with endothelial cells stimulate memory B cells resulting in local antibody production.

A team at the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells.

Unlike peripheral capillaries, which allow the relatively free exchange of substances with the surrounding tissue, the capillaries in the brain are tightly packed with endothelial cells.

«We're very interested in following up by finding more direct proof that if you block the recruitment of immune cells to tumors, you can reverse this phenomenon in these animals with endothelial cell insulin resistance,» Rask - Madsen says.

However, efforts to examine the in vitro behavior of tumor cells with endothelial cells from different anatomical regions have been prohibited because, in large part, of the limited number of organ - derived endothelial cell lines available for study.

Matrigel - containing plates were allowed to incubate at 37 °C for 30 min and then seeded with endothelial cells at a density of 4 × 104 cells / well in 10 % DMEM.

The vessels are lined with endothelial cells, which secrete chemical signals that help stem cell survive.

In the chamber, tubes about the thickness of a human hair were lined with endothelial cells as in natural blood vessels.

By using this technique, we demonstrated that the telomere G - tail length of leukocytes is significantly correlated with endothelial function and severity of ARWMCs,» said Professor Hidetoshi Tahara, a principal investigator of this study at the Department of Cellular and Molecular Biology, Hiroshima University.

They first devised a nanoscale plastic scaffold and then seeded it with common muscle precursor cells called myoblasts, along with endothelial cells of the sort found on the inside of blood vessels.

Not exact matches

The study concluded that including nuts within a healthy dietary pattern may have favorable effects on endothelial dysfunction, which is associated with cardiovascular disease.

The study, which appears online October 29 in the journal Science Signaling, describes a previously uncharacterized interaction between GRK2 and an enzyme called endothelial nitric oxide synthase (eNOS), in which the two enzymes attempt to block one another's activity, with different outcomes on heart function.

«We can generate cerebral organoids with integrated endothelial tissue, this tissue forms tubes, and we can induce these tubes to sprout» into the nutrient broth that the cerebral organoids grow in, said John Aach, a geneticist in Church's lab.

He and his colleagues grew the vasculature with blood - vessel - making (endothelial) cells.

Among dozens of mouse studies, he presented work led by Moderna Co-Founder Kenneth Chien, then at Harvard Medical School in Boston, showing that mice recovering from induced heart attacks survived longer and had stronger hearts when injected with mRNA encoding a protein that drives blood vessel formation — vascular endothelial growth factor (VEGF).

Nevertheless, it provides initial evidence for the association of telomere G - tail length with aging, endothelial function, and ARWMCs in patients with vascular risk factors.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

An international study of more than 5,417 people helps pinpoint the genetic risk factors associated with Fuchs endothelial corneal dystrophy, the most common disorder requiring corneal transplantation.

«In most individuals with Fuchs Endothelial Corneal Dystrophy (FECD) the cause of the disease is unknown.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

Researchers discovered three novel genetic mutations associated with Fuchs endothelial corneal dystrophy, the most common corneal disorder requiring transplantation.

With the best - performing particles, the researchers reduced gene expression by more than 50 percent, for a dose of only 0.20 milligrams per kilogram of solution — about one - hundredth of the amount required with existing endothelial RNAi delivery vehicWith the best - performing particles, the researchers reduced gene expression by more than 50 percent, for a dose of only 0.20 milligrams per kilogram of solution — about one - hundredth of the amount required with existing endothelial RNAi delivery vehicwith existing endothelial RNAi delivery vehicles.

To make their molecular delivery vehicles, the researchers combined the polymersomes with a protein called LRP1, which is abundant in the endothelial cells that make up the blood — brain barrier wall.

They found that, while the grafts of undifferentiated iPS cells harbored large numbers of T cells of only a few specificities — indicating a robust immune response — those found in grafts of the two types of endothelial cells were more diverse, suggesting a more limited response associated with a phenomenon known as self - tolerance.

When zebrafish with the green fluorescing endothelial gene matured, the researchers observed green FGPs on the surface of the fish's brains — confirming that these cells arose from endothelial tissue.

Professor Takao Hamakubo's group at the Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), have shown that PTX3 forms strong bonds with histones and partially unfolds, leading to a disordered coaggregation of histone and PTX3 and protecting human endothelial cells from damage.

Perimenopausal women had higher FMD, and their blood vessels dilated faster — indicating better endothelial function — compared with postmenopausal women, when both aerobic fitness groups were combined.

In contrast, the elongated nanorods have a larger surface area that is in contact with the surface of the endothelial cells.

The researchers, working with cell cultures, first observed how individual tumour cells kill specific cells in the vascular wall, called endothelial cells.

Researchers from Massachusetts Eye and Ear have, for the first time, identified rapidly proliferating cells (known as «neural crest - derived progenitor cells») in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs» Endothelial Corneal Dystrophy (FECD), a condition in which the cells responsible for keeping the cornea clear die prematurely — often leading to blindness.

The epithelium's maturation into a villus intestinal epithelium with long finger - like extensions was helped along by co-culturing human intestinal microvascular endothelial cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through which feeding medium was flowed.

To verify that the process worked, the endothelial cells with the inversion - corrected genes were transplanted into F8 deficient mice (mice with hemophilia A) and the mice started producing the F8 clotting factor on their own, which essentially cured them of hemophilia A.

Linking the vascular endothelial growth factor (VEGF) genetic pathway with a specific disease characteristic among SLE patients represents an important step towards unravelling the genetic basis of different SLE clinical presentations.

«ECPR and a factor in the blood called protein C act as a «brake» on blood coagulation and endothelial cell inflammation and also enhance the viability and integrity of blood vessels, but when the malaria parasites use PfEMP1 to bind EPCR, they may interfere with the normal function of EPCR, and thus the binding can be the catalyst for the violent reaction,» he explains.

Cells from the penises with stem cell - laced grafts contained more neuronal and endothelial NOS, enzymes that help trigger and maintain erections.

To study this barrier and determine why a lack of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of human endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow of blood through a vessel and evaluate the cells» responses.

The researchers were able to increase platelet production in the bioreactor by embedding the silk with active endothelial cells and endothelial - related molecular proteins that support platelet formation.

They measured blood vessel function with a standard test of arterial endothelial function, a flow - mediated dilatation test (FMD) that uses ultrasound.

Genentech scientists led by Mark Dennis designed an antibody with two arms — one that binds to BACE1 and inhibits its activity and one that binds to the transferrin receptor and tricks endothelial cells into transporting the antibody across the blood - brain barrier.

Dengue virus NS1 triggers endothelial permeability and vascular leak, and vaccination with NS1 induces a protective antibody response.

High Serum Vascular Endothelial Growth Factor (VEGF) Level Is An Adverse Prognostic Factor In High Risk Diffuse Large B - Cell Lymphoma (DLBCL) Patients Treated with Dose - Dense Chemoimmunotherapy and Systemic CNS Prophylaxis.

This experiment uses quantitative PCR to detect the expression level of POSTN in CD34 + / CD31 − pulmonary fibroblasts, CD31 + endothelial cells, and CD45 + immune cells isolated from lungs of mice with macrometastases, which is a replication of the experiment reported in Figure 2H.

B, CSCs isolated from 231BrM infected with lentivirus of miR7 or KLF4 expression plasmids were seeded on top of mouse brain endothelial cells or Matrigel.

Phase - contrast images of organ - derived endothelial cells (37 °C) on Matrigel surface (A) and after 4 h of incubation with DiI - Ac - LDL (B).

When primary cultures from these mice are stimulated with proinflammatory cytokines, the endothelial cell fraction responds by up - regulating the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1.

One of the primary objectives of this study was to establish a protocol to facilitate the identification and selection of microvascular endothelial cells from primary organ cultures with a high degree of precision.